Low blood cholesterol and low platelet serotonin levels in violent suicide attempters

Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder

“…These findings are consistent with significantly decreased platelet 5-HT concentration found in suicidal depressed patients (Mann et al, 1992;Muck-Seler et al, 1996;Pivac et al, 1997;Rogenbach et al, 2007), in patients with a history of violent suicide attempts (Alvarez et al, 1999), in suicidal patients with a first episode of psychosis (Marcinko et al, 2007), in suicidal patients with schizophrenia (Braunig et al 1989), or schizoaffective disorder (Rao et al 1994). , 1997), and a smaller number of male patients in acute psychosis (Marcinko et al, 2007), argue that reduced platelet 5-HT concentration might serve as a predictor of suicidal behavior.…”

Platelet serotonin and serum lipids in psychotic mania

“…Since no correlation was found between high platelet 5-HT and low cholesterol and LDL in mania (present study), or low platelet 5-HT and low cholesterol levels in suicide attempters (Alvarez et al, 1999), it is possible that platelet 5-HT and cholesterol levels are negatively correlated only in the presence of hypercholesterolaemia (Smith and Betteridge, 1997).…”

Cholesterol and suicide attempts: A prospective study of depressed inpatients

“…Comparisons of suicide attempters to well controls have yielded similar results (Gallerani et al, 1995;Alvarez et al, 1999;Sarchiapone et al, 2000;Atmaca et al, 2002b;Kim et al,, 2002;Tripodianakis et al, 2002;Lee and Kim, 2003). Some have found the association between low cholesterol and suicide attempts to be strongest among those with violent suicide attempts or with a history of such attempts (Alvarez et al, 2000;Bocchetta et al, 2001;Atmaca et al, 2003b;Vevera et al, 2003;Kim and Myint, 2004;Marcinko et al, 2005).…”