Low body mass index and use of corticosteroids, but not cholestasis, are risk factors for osteoporosis in patients with chronic liver disease

Ormarsdóttir, Sif; Ljunggren, Östen; Mallmin, Hans; Brahm, Helena; Lööf, Lars

doi:10.1016/s0168-8278(99)80167-6

Cited by 52 publications

(23 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, some scientists deny the existence of a link between IGF-I and BMD in men [54][55][56]. Papers dealing with osteoporosis in liver disease suggest the existence of a link between reduced BMI and decreased IGF-I and BMD [57][58][59][60][61]. However, our observation did not confirm such a relationship.…”

Section: Prace Oryginalnecontrasting

confidence: 77%

Czynność osi GH/IGF-I, stężenie hormonów kalciotropowych we krwi oraz gęstość mineralna kości u młodych osób z przewlekłym wirusowym zapaleniem wątroby

Marek¹,

Kajdaniuk²,

Niedziołka³

et al. 2015

Endokrynologia Polska

View full text Add to dashboard Cite

Section: Prace Oryginalnecontrasting

confidence: 77%

Czynność osi GH/IGF-I, stężenie hormonów kalciotropowych we krwi oraz gęstość mineralna kości u młodych osób z przewlekłym wirusowym zapaleniem wątroby

Marek¹,

Kajdaniuk²,

Niedziołka³

et al. 2015

Endokrynologia Polska

View full text Add to dashboard Cite

“…There is a certain heterogeneity regarding the prevalence of osteoporosis in patients with chronic liver disease, which partly depends on patient selection and diagnostic criteria [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] (Table 1). Actually, chronic liver disease consists of cirrhotic and non-cirrhotic patients, and analyses have generally been performed in cirrhotics with a broad range of disease severity, but also in pre-cirrhotic patients.…”

Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 99%

“…Overall, approximately 23% of the patients with liver disease have osteoporosis, with a higher prevalence in patients with primary biliary cirrhosis (about 32%), since they have two additional risk factors: chronic cholestasis and female gender [8,9,15,[18][19][20][21][22][23]. The prevalence of fractures in patients with liver disease ranges from 6% to 35% [3,5,7,8,10,12,16,19,21,[24][25][26][27]. Fractures are more prevalent in postmenopausal women than in males and young women [5], and in patients with autoimmune hepatitis treated with glucocorticoids [26].…”

Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 99%

Treatment of bone disorders in liver disease

Parés

Guañabens

2006

Journal of Hepatology

View full text Add to dashboard Cite

“…Previous studies have indicated that there is no correlation between bone mineral density (BMD) and the etiology of the liver disease in cirrhotic patients undergoing orthotopic liver transplantation (OLTx) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Bone Metabolism and Gonad Function in Male Patients Undergoing Liver Transplantation: A Two-Year Longitudinal Study

et al. 2001

View full text Add to dashboard Cite

Osteodystrophy is a major complication of end-stage liver disease, especially in postmenopausal women. Our aim in this study was to evaluate bone metabolism and gonad function in men undergoing orthotopic liver transplantation (OLTx). Twenty-three consecutive men (mean age 48+/-13 years) evaluated for OLTx were studied, assessing the following parameters at baseline and 3, 6, 12 and 24 months after OLTx: lumbar spine (L2-L4) bone mineral density (BMD), parathyroid hormone (PTH), osteocalcin (BGP), 25-hydroxyvitamin D (25OHD), free testosterone (FT) and gonadotropins (FSH, LH). At baseline, 12 patients (52%) had a T-score <-2.5 SD and the mean BMD was 0.806+/-0.11 g/cm2 (range 0.470-1.045 g/cm2). The BMD was lower 3 months after OLTx and significantly higher 12 and 24 months after OLTx. A significant increase in serum BGP was observed at 6, 12 (p<0.05) and 24 months (p<0.005) after OLTx. The mean serum PTH level was 26.6+/-3.1 pg/ml at baseline and increased significantly at 12 and 24 months (to 49.4+/-9.9 and 61.2+/-10.1 pg/ml, respectively; p<0.05). 25OHD serum levels were low at baseline and returned to the normal range after 12 and 24 months (baseline, 8.73+/-1.54 ng/ ml; 12 months, 16.4+/-2.6 ng/ml; 24 months, 17.67+/-3.1 ng/ml; p<0.05). FT was significantly lower at baseline than in a group of 10 healthy controls (5.09+/-10.99. vs 10.3+/-1.1 pg/ml; p<0.0001). After OLTx a significant increase in FT was recorded at 6, (p<0.05) and 24 months (p<0.005). FT was not correlated with BMD, however. After OLTx an increase in FSH and LH was observed (but failed to reach statistical significance) at 3 and 6 months, followed by a slight reduction at 12 and 24 months. Thus a high proportion of men with end-stage liver disease do have osteoporosis. After OLTx, an early recovery of gonad function is observed, followed by an increase in bone mass, which occurs from the sixth month onward.

show abstract

Low body mass index and use of corticosteroids, but not cholestasis, are risk factors for osteoporosis in patients with chronic liver disease

Cited by 52 publications

References 37 publications

Czynność osi GH/IGF-I, stężenie hormonów kalciotropowych we krwi oraz gęstość mineralna kości u młodych osób z przewlekłym wirusowym zapaleniem wątroby

Czynność osi GH/IGF-I, stężenie hormonów kalciotropowych we krwi oraz gęstość mineralna kości u młodych osób z przewlekłym wirusowym zapaleniem wątroby

Treatment of bone disorders in liver disease

Bone Metabolism and Gonad Function in Male Patients Undergoing Liver Transplantation: A Two-Year Longitudinal Study

Contact Info

Product

Resources

About