Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones

Prochaska, Megan; Taylor, Eric N.; Vaidya, Anand; Curhan, Gary C.

doi:10.2215/cjn.01420217

“…Similar to our study cohort, a Japanese cohort also had a lower prevalence of hypercalciuria [17]. Low BMD is found to be associated with hypercalciuria; this could be an independent risk factor for developing urolithiasis [24][25][26]. Owing to our unique demography, a low prevalence of hypercalciuria was observed in those with low BMD and postmenopausal women; we hypothesize that a different mechanism from hypercalciuria may cause a lower BMD in Japanese patients with urolithiasis.…”

Section: Discussionsupporting

confidence: 79%

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Taguchi

¹

,

Hamamoto

²

,

Okada

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods: To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-hour urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results: Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio=0.44, p=0.007), whereas a T-score <−2.5 and hyperoxaluria were associated with symptoms (odds ratio=2.59, p=0.037; odds ratio=0.45, p=0.01; respectively). Conclusion: These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

show abstract

“…Similar to our study cohort, a Japanese cohort also had a lower prevalence of hypercalciuria [18]. Low BMD is found to be associated with hypercalciuria; this could be an independent risk factor for developing urolithiasis [25][26][27]. Owing to our unique demography, a low prevalence of hypercalciuria was observed in those with low BMD and postmenopausal women; we hypothesize that a different mechanism from hypercalciuria may cause a lower BMD in Japanese patients with urolithiasis.…”

Section: Discussionsupporting

confidence: 79%

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: A single-center retrospective cohort study

Taguchi

¹

,

Hamamoto

²

,

Okada

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods: To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-hour urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results: Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio=0.44, p=0.007), whereas a T-score <−2.5 and hyperoxaluria were associated with symptoms (odds ratio=2.59, p=0.037; odds ratio=0.45, p=0.01; respectively). Conclusion: These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

show abstract

“…Similar to our study cohort, a Japanese cohort also had a lower prevalence of hypercalciuria [ 18 ]. Low BMD is found to be associated with hypercalciuria; this could be an independent risk factor for developing urolithiasis [ 25 – 27 ]. Owing to our unique demography, a low prevalence of hypercalciuria was observed in those with low BMD and postmenopausal women; we hypothesize that a different mechanism from hypercalciuria may cause a lower BMD in Japanese patients with urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

Taguchi

¹

,

Hamamoto

²

,

Okada

³

et al. 2020

View full text Add to dashboard Cite

Background Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-h urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio = 0.44, p = 0.007), whereas a T-score < − 2.5 and hyperoxaluria were associated with symptoms (odds ratio = 2.59, p = 0.037; odds ratio = 0.45, p = 0.01; respectively). Conclusion These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

show abstract

Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones

Cited by 31 publications

References 37 publications

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: A single-center retrospective cohort study

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

Contact Info

Product

Resources

About