Low bone density and osteoporosis among older adults with Alzheimer`s disease, vascular dementia, and mixed dementia: A Cross-sectional Study With Prospective Enrollment

Başgöz, Bilgin Bahadır; İnce, Semra; Safer, Vildan Binay; Naharcı, Mehmet İlkin; Taşçı, İlker

doi:10.5606/tftrd.2020.3803

Cited by 17 publications

(7 citation statements)

References 45 publications

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“…We reported an10.6% pervasiveness of osteoporosis in our study. These results are comparable with the previous study of Vaishya R in which he observed an 8.99% prevalence of osteoporosis in New Delhi, India [7][8] . However, in the northernIndia study on osteoporosis by Kumar et al in 2017; prevalence was observed as 9% [9][10] .…”

Section: Discussionsupporting

confidence: 91%

A Descriptive Cross-Sectional Study on the Incidence of Osteoporosis among Adults

Mahmood¹,

Kashif²,

Afzaal³

et al. 2022

PJMHS

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Introduction:Osteoporosis is a communal metabolic bone disease categorized by augmented bone fragility, although it has not been properly diagnosed or treated. As the life expectancy of the population increases, it becomes aserious and urgentuniversal epidemic. It is anavoidableconditionand has no clinical symptoms tilloccurrence of fracture. Primary treatment and diagnosis are very important. Therefore,our study aim was to determine the osteoporosisincidence in adults admitted to the Rheumatology department. Study Design: A descriptive cross-sectional study. Place and Duration: In the Medicine and Rheumatology departments of Jinnah Hospital Lahore, Mayo hospital Lahore and Niazi Medical Complex Teaching hospital Sargodha for one-year duration from August 2020 July 2021. Methods:Afterconsent from the Ethical board appropriate sampling had been performed. The collection of data and input was performed in Microsoft Excel; point estimation was calculated with confidence interval of 95% along with coefficient and frequency for binary data.All the patients aged 20 years with or without orthopedic problems were recruited. We excluded all the patients with diagnosed calcaneum fracture and any other pathology especially osteomyelitis of the right calcaneum. Initially, a sample size of 400 patients was taken however after convenient sampling this sample size was reduced to 245 patients for final analysis. Results: The total osteoporosisincidenceamong245 participants was diagnosed in26 (10.6%) with the confidence interval of 95%(5.8-11.2%). Among the patients, 102 (41.6%) are men and 143 (58.4%) are women. The participants mean age was 40.40 ± 15.20 years. Conclusions: The osteoporosisincidence in this analysis is high and is constant with various studies in South Asia. Primaryrecognition of osteoporosis with quantifiable ultrasound of the calcaneus can be a virtuous tool of screening.

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Section: Discussionsupporting

confidence: 91%

A Descriptive Cross-Sectional Study on the Incidence of Osteoporosis among Adults

Mahmood¹,

Kashif²,

Afzaal³

et al. 2022

PJMHS

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“…The authors suggested that estrogen could mediate this association [60]. The association between dementia, low BMD, and osteoporosis was examined in 363 Turkish adults aged 65 years and over (63% female) [61]. In this study, BMD assessed by DXA was found lower in participants with dementia, but without differences based on the type of dementia (AD, vascular dementia, or mixed dementia), gender, disease duration, or severity.…”

Section: Bone and Cognitionmentioning

confidence: 73%

Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms

Sui

Balanta‐Melo

Pasco

et al. 2022

Curr Osteoporos Rep

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Purpose of Review Cognitive impairment is associated with obesity, sarcopenia, and osteoporosis. However, no critical appraisal of the literature on the relationship between musculoskeletal deficits and cognitive impairment, focusing on the epidemiological evidence and biological mechanisms, has been published to date. Herein, we critically evaluate the literature published over the past 3 years, emphasizing interesting and important new findings, and provide an outline of future directions that will improve our understanding of the connections between the brain and the musculoskeletal system. Recent Findings Recent literature suggests that musculoskeletal deficits and cognitive impairment share pathophysiological pathways and risk factors. Cytokines and hormones affect both the brain and the musculoskeletal system; yet, lack of unified definitions and standards makes it difficult to compare studies. Summary Interventions designed to improve musculoskeletal health are plausible means of preventing or slowing cognitive impairment. We highlight several musculoskeletal health interventions that show potential in this regard.

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“…Osteoporosis and fragility fractures have a high prevalence among persons with dementia and greatly contribute to the morbidity and mortality of an aging population 1–3. In addition to dietary and mobility factors that contribute to low bone mineral density (BMD) in older age,1 there appears to be a common pathway underlying neurodegeneration and bone health as low BMD has been associated with more advanced normal age-related brain parenchyma atrophy,4 prevalent Alzheimer disease (AD) and vascular dementia,5,6 as well as an increased risk for developing AD 7,8. One putative link between BMD and brain aging is cumulative exposure to estrogen supported by data showing that the length of the reproductive period in women was inversely related to their risk of cognitive impairment and protective against the development of AD 9.…”

mentioning

confidence: 99%

Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function

Stefanidou

O’Donnell

Himali

et al. 2021

Alzheimer Disease &Amp; Associated Disorders

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Low bone density and osteoporosis among older adults with Alzheimer`s disease, vascular dementia, and mixed dementia: A Cross-sectional Study With Prospective Enrollment

Cited by 17 publications

References 45 publications

A Descriptive Cross-Sectional Study on the Incidence of Osteoporosis among Adults

A Descriptive Cross-Sectional Study on the Incidence of Osteoporosis among Adults

Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms

Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function

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