Low but detectable serum thyroid-stimulating hormone concentrations in                ambulant subjects not receiving thyroxine

Chatterjee, Sadhana; O'Malley, B P; Price, D.E.; Fielding, A.S.; Aitken, R. G.

doi:10.1258/000456303770367225

Cited by 3 publications

(1 citation statement)

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“…Multiple diseases, which frequently entail polytherapy with the use of multiple drugs, influence the levels of hormones in vivo and the measurement biomarkers as well as drugs concentration by immunochemistry in vitro [6]. The coexistence of multiple diseases may cause secondary changes in hormone levels as it is the case with the level of thyroid-stimulating hormone (TSH) in nonthyroidal diseases [7–9]. Moreover, in an elderly population, the presence of autoantibodies due to autoimmune or chronic diseases is more frequent than it is in the younger population.…”

Section: Introductionmentioning

confidence: 99%

Interpretation of Hormone Levels in Older Patients: Points for Consideration

Sztefko

Szybowska

2012

International Journal of Endocrinology

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Blood hormone and tumor marker concentrations are usually determined by immunochemical methods which are based on an unique reaction between antigen and assay capture antibody. Despite the speed and simplicity of assays performance on automatic immunochemistry platforms, the interpretation of final results requires a deep knowledge of method fallibility. General lack of immunoassays standardization, presence of cross-reacting substances in patient’s sample, limitation of free hormones measurement due to abnormal analyte binding protein concentrations, assay interferences due to patient’s autoantibodies, and heterophilic antibodies, as well as proper interpretation of very low- and very high-sample analyte levels, are the main points discussed in respect to hormones and tumor markers measurement in geriatric population.

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Section: Introductionmentioning

confidence: 99%