Low C24‐OH and C22‐OH sulfatides in human renal cell carcinoma

Kim, Il Chan; Bang, Geul; Lee, Jeong Hwa; Kim, Kwang Pyo; Kim, Young Hwan; Kim, Hark Kyun; Chung, Jinsoo

doi:10.1002/jms.3736

Cited by 11 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous work, we compared 157 tumor and autologous nonmalignant tissues from 80 patients with RCC 18 , and we reported decreased concentrations of monohexosyl sulfatides (SHexCer) with additional hydroxyl in the ceramide part in the tumor tissue compared to the non-neoplastic autologous tissue. These observations are consistent with the results reported by Kim et al 13 . We also found elevated levels of sulfatides composed of two hexosyl units (SHex2Cer) in tumor tissues compared to adjacent nonneoplastic tissues.…”

Section: Introductionsupporting

confidence: 94%

“…Sulfatides, a class of low-abundant sphingolipids, also seem to be a good target for such research 12 . The importance of sulfatide metabolism and sulfotransferase genes expression for the morphological differentiation of tumor and metastatic potentials of the colorectal, ovarian, or renal carcinoma was shown in numerous reports 13,14,15,16,17 . Sulfatides participate in the adhesion to functional proteins, the maintenance and modification of ion channels, and the induction of cell differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…Significantly altered sulfatide profiles are usually observed in tumor tissues or cells because of the high local concentrations of studied lipids. However, only a few studies have been published on sulfatide analysis in cells and tissues of RCC patients 13,18 . To the best of our knowledge, no work on the analysis of sulfatides in body fluids of RCC patients has been reported to date in the literature.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma

Jirásko

Idkowiak

Wolrab

et al. 2022

Preprint

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) represents the most common type of kidney cancer with the highest incidence and mortality rate among all urological malignancies. In this study, we show that RCC-related processes change body fluids sphingolipid concentrations, which may be used to monitor cancer occurrence in low-invasive lipid-based blood and urine tests. We investigate 674 plasma, urine, and tissue samples from 369 RCC patients and controls. For the first time, we show the significant concentration changes of low abundant sulfatides in plasma and urine of RCC patients. Elevated concentrations of lactosylsulfatides, decreased concentrations of sphingomyelines with long saturated N-fatty acyls and sulfatides with hydroxylated fatty acyls are the most crucial alternations in RCC. These changes are stage-dependent and are more emphasized in late-stage RCC. Similar trends in body fluids and tissues indicate that RCC widely influences lipid metabolism and highlights the potential of lipidomic profiling for cancer detection.

show abstract

Section: Introductionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma

Jirásko

Idkowiak

Wolrab

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…(Bruker Daltonics). Mass calibration was performed with external standards using lipid-mixed calibration standards with m/z ranges of 674-834 Da (positive ion mode) and 564-906 Da (negative ion mode) prior to data acquisition to achieve a mass accuracy of better than 50 ppm ( 12,24 ). A mass resolution of M/ ⌬ M ‫ف‬ 20,000 was typically achieved in the mass window of PLs.…”

Section: Ims Analysismentioning

confidence: 99%

Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease

Hong

Kang

Kim

et al. 2016

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

This article is available online at http://www.jlr.org Several hypotheses regarding the cause of AD have been proposed, among which the amyloid hypothesis is the most widely accepted ( 2 ). According to this hypothesis, AD is caused by abnormal accumulation of misfolded ␤ -amyloid (A ␤ ), a sequential cleavage product produced from amyloid precursor protein (APP) by ␤ -and ␥ -secretases, and hyperphosphorylated tau protein. Several lines of evidence support the idea that A ␤ can trigger the hyperphosphorylation of tau, resulting in neuronal degeneration in the brain ( 3, 4 ).There is evidence that FFAs are associated with several signaling processes related to the pathogenesis of AD. In particular, palmitic and stearic acid induce AD by triggering hyperphosphorylation of tau protein ( 5 ). Membrane phospholipids (PLs) are a prominent source of FFAs. Under disease conditions, phospholipase enzymes are produced in excess, inducing the hydrolysis of PLs and the release of FFAs. It is reasonable to hypothesize that alterations in PL concentrations are closely related to the pathogenesis of AD, as PLs perform a number of important cellular roles, including stabilization of membrane ion channels, neurotransmission, and the localization of A ␤ plaques to PL cores ( 6, 7 ).As a result of progress in MS, and MALDI-imaging MS (IMS) in particular, the analysis of PL changes during disease progression has become feasible. MALDI-IMS is a unique tool that integrates molecular and histological information together with information attained using Alzheimer's disease (AD), the most common form of dementia, is primarily caused by abnormal protein kinesis and the accumulation of aggregated proteins in the brain. This work was supported

show abstract

“…Shotgun lipidomics based on electrospray ionization mass spectrometry (ESI-MS) allows deep molecular profiling of a sample without significant losses of chemical information [26,27]. The high diagnostic potential of lipidomics has been shown in many areas of medicine, particularly in oncology: lung, thyroid gland, breast, stomach, pancreas, colorectal, liver, kidney, prostate, ovarian, and endometrium cancer [28,29,[38][39][40][41][42][43][44][45][46][47]30,[48][49][50][51][31][32][33][34][35][36][37]. MS studies of lipid profiles in tissues and blood plasma have revealed new promising biomarkers of endometriosis (benign gynecological disorder) [26,27,32,33,37,44,47].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Lipid Profile Upon Uterine Fibroids and Its Recurrence

Tonoyan

Chagovets

Стародубцева

et al. 2021

Preprint

View full text Add to dashboard Cite

Background. Uterine fibroids (UF) is the most common (about 70% cases) type of gynecological disease, with the recurrence rate varying from 11% to 40%. Because UF has no distinct symptomatology and is often asymptomatic, the specific and sensitive diagnosis of UF as well as the assessment for the probability of UF recurrence pose considerable challenge.Aim. The aim of this study was to characterize alterations in the lipid profile of tissues associated with the first-time diagnosed UF and recurrent uterine fibroids (RUF) and to explore the potential of mass spectrometry (MS) lipidomics analysis of blood plasma samples for the sensitive and specific determination of UF and RUF with low invasiveness of analysis.Materials and methods. MS analysis of lipid levels in the myometrium tissues, fibroids tissues and blood plasma samples was carried out on 66 patients, including35 patients with first-time diagnosed UF and 31 patients with RUF. The control group consisted of 15 patients who underwent surgical treatment for the intrauterine septum. Fibroids and myometrium tissue samples were analyzed using direct MS approach. Blood plasma samples were analyzed using high performance liquid chromatography hyphened with mass spectrometry (HPLC/MS). MS data were processed by discriminant analysis with projection into latent structures (OPLS-DA).Results. Significant differences were found between the first-time UF, RUF and control group in the levels of lipids involved in the metabolism of glycerophospholipids, sphingolipids, lipids with an ether bond, triglycerides and fatty acids. Significant differences between the control group and the groups with UF and RUF were found in the blood plasma levels of cholesterol esters, triacylglycerols, (lyso) phosphatidylcholines and sphingomyelins. Significant differences between the UF and RUF groups were found in the blood plasma levels of cholesterol esters, phosphotidylcholines, sphingomyelins and triacylglycerols. Diagnostic models based on the selected differential lipids using logistic regression showed sensitivity and specificity of 88% and 86% for the diagnosis of first-time UF and 95% and 79% for RUF, accordingly.Conclusion. This study confirms the involvement of lipids in the pathogenesis of uterine fibroids. A diagnostically significant panel of differential lipid species has been identified for the diagnosis of UF and RUF by low-invasive blood plasma analysis. The developed diagnostic models demonstrated high potential for clinical use and further research in this direction.

show abstract

Low C24‐OH and C22‐OH sulfatides in human renal cell carcinoma

Abstract: . Low C24-OH and C22-OH sulfatides in human renal cell carcinoma.

Cited by 11 publications

References 1 publication

Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma

Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma

Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease

Alterations in Lipid Profile Upon Uterine Fibroids and Its Recurrence

Contact Info

Product

Resources

About