Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention

Walaszek, Michał; Kachlik, Zofia; Cubała, Wiesław Jerzy

doi:10.1080/1028415x.2024.2303218

Cited by 3 publications

(2 citation statements)

References 121 publications

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“…Interestingly, the ‘specific’ FM measures (WPI and SS) did not change significantly even 2 months after the start of the 4-week diet, while the key measures indicating disability did improve, especially the FIQ and the subscores of the BPI, which relate to disability and pain’s interference with physical and occupational activities. Apart from the positive effect on mood through the general improvement of everyday abilities, the antiinflammatory Mediterranean diet could directly improve the symptoms of anxiety and depression, as numerous studies have suggested [ 30 , 31 ]. This is particularly important in people with FM, as symptoms of depression are very common and contribute to the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia

Casini,

Ladisa,

Clemente

et al. 2024

Pain Ther

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Introduction Fibromyalgia is a form of chronic pain that affects a large number of women. It can start at any age and last a lifetime, with no cure. The Mediterranean diet is said to have an anti-inflammatory effect. Therefore, this study was conducted to investigate possible beneficial effects of a personalized Mediterranean diet in patients with fibromyalgia. Methods Outpatients with fibromyalgia were recruited and invited to participate in the study, including clinical, nutritional, and dietary assessments. Patients received a personalized Mediterranean diet (DIET group) or a general balanced diet (NODIET group) to be followed for 8 weeks. All tests were carried out at baseline and repeated after 4 and 8 weeks. Results In total, 100 subjects were included, 84 of whom completed the study. Most of the patients showed incorrect habits in terms of food choices, timing of meals and composition of nutrients. The DIET group showed an improvement in most of the fibromyalgia parameters, including the disability scores, fatigue, and anxiety. Conclusions The habit of eating inflammatory foods and/or eating meals with the wrong nutritional content would increase the negative status of patients with fibromyalgia. With this study, we confirm that proper attention to feeding habits would improve the quality of life of such patients.

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Section: Discussionmentioning

confidence: 99%

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia

Casini,

Ladisa,

Clemente

et al. 2024

Pain Ther

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“…Microglia are activated and, as a consequence, there are increased levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 12 (IL-12), and tumor necrosis factor-α (TNF-α) in the cerebrospinal fluid [66,67], and increased translocator protein, a marker of central inflammation, in the temporal cortex and anterior cingulate cortex of the brain [68,69]. The KD and other types of diets based on restricted carbohydrate intake may prevent the occurrence of MDD, reduce depression symptoms, cause a mood improvement, and lower the risk of cognitive impairment [70]. As previously mentioned, the KD can positively influence the gut microbiota composition.…”

Section: Therapeutic Effect Of the Ketogenic Diet In Depression 41 Et...mentioning

confidence: 99%

The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice

Rog,

Wingralek,

Nowak

et al. 2024

JCM

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The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that mimics the physiological state of fasting. The potential therapeutic effects in many chronic conditions have led to the gaining popularity of the KD. The KD has been demonstrated to alleviate inflammation and oxidative stress, modulate the gut microbiota community, and improve metabolic health markers. The modification of these factors has been a potential therapeutic target in serious mental illness (SMI): bipolar disorder, major depressive disorder, and schizophrenia. The number of clinical trials assessing the effect of the KD on SMI is still limited. Preliminary research, predominantly case studies, suggests potential therapeutic effects, including weight gain reduction, improved carbohydrate and lipid metabolism, decrease in disease-related symptoms, increased energy and quality of life, and, in some cases, changes in pharmacotherapy (reduction in number or dosage of medication). However, these findings necessitate further investigation through larger-scale clinical trials. Initiation of the KD should occur in a hospital setting and with strict care of a physician and dietitian due to potential side effects of the diet and the possibility of exacerbating adverse effects of pharmacotherapy. An increasing number of ongoing studies examining the KD’s effect on mental disorders highlights its potential role in the adjunctive treatment of SMI.

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Low-carbohydrate diet as a disease modifier for relapse prevention of treatment-resistant depression. Spotlight on neuroplasticity and brain-derived neurotrophic factor

Kachlik,

Walaszek,

Cubała

2024

Medical Hypotheses

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Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention

Cited by 3 publications

References 121 publications

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia

The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice

Low-carbohydrate diet as a disease modifier for relapse prevention of treatment-resistant depression. Spotlight on neuroplasticity and brain-derived neurotrophic factor

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