Low coherence interferometry approach for aiding fine needle aspiration biopsies

Chang, Ernest W.; Gardecki, Joseph A.; Pitman, Martha B.; Wilsterman, Eric J.; Patel, Ankit; Tearney, Guillermo J.; Iftimia, Nicusor

doi:10.1117/1.jbo.19.11.116005

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…There is also the potential to incorporate a forward-facing OCT probe within the biopsy needle to reduce risk during needle insertion. These designs have already been demonstrated for non-neurosurgical applications ( 44 ), and our team has demonstrated a forward-facing optical design similar to that used in this current paper ( 60 ). We note that the diameter of the distal focusing optics of the probe is only 250 μm, and the body of the probe is 900 μm in diameter due to a protective Hytrel jacket around the fiber.…”

Section: Discussionmentioning

confidence: 84%

“…This has necessitated the development of miniaturized fiber-optic probes, which may be incorporated into the hypodermic needle to provide guidance near the distal tip of the needle as it is inserted at depth (41). Previous studies have demonstrated the use of these imaging needles in a range of tissues, including breast (42)(43)(44), lung (45,46), and brain (47,48). While the design of these probes is well established, their use in human studies is very limited, with most work restricted to animal or ex vivo human tissue, and no previous studies have demonstrated their use for in vivo human brain.…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans

et al. 2018

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans

et al. 2018

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“…Another major advantage of OCT is that the technology evolved to a needle‐based platform, enabling microscopic resolution 3D optical biopsies of tissue. These ultra‐thin high resolution needle‐based imaging platforms have already proven their efficacy in the lymph nodes , lung , breast and skeletal muscle . It is expected that in the future, technology will become faster, and resolutions will become higher (to the micrometer level), resulting in even higher diagnostic accuracy.…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

Muller

Bruin

Brandt

et al. 2016

Journal of Biophotonics

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The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm(-1) ; 3.85 mm(-1) ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor was visible in two subsequent histopathological prostate slices. This analysis could be performed in 3 patients. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.23 mm(-1) ; 4.11 mm(-1) ; p < 0.0001) for all patients grouped together. The area under the ROC curve was 0.89. Functional OCT of the prostate has shown to differentiate between cancer and healthy prostate tissue. The optical attenuation coefficient in malignant tissue was significantly higher in malignant tissue compared to benign prostate tissue. Further studies are required to validate these initial results in a larger group of patients with a more tailored histopathology matching protocol.

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“…Such technologies include Raman spectroscopy, dynamic light scattering, optical coherence tomography (OCT), etc. [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Among them, OCT has shown significant promise due to its ability to assess true tissue morphology within relatively large volumes of tissue, such as the size of the biopsy cores, at a higher speed than of the other modalities.…”

Section: Introductionmentioning

confidence: 99%

Core Needle Biopsy Guidance Based on Tissue Morphology Assessment with AI-OCT Imaging

et al. 2023

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This paper presents a combined optical imaging/artificial intelligence (OI/AI) technique for the real-time analysis of tissue morphology at the tip of the biopsy needle, prior to collecting a biopsy specimen. This is an important clinical problem as up to 40% of collected biopsy cores provide low diagnostic value due to high adipose or necrotic content. Micron-scale-resolution optical coherence tomography (OCT) images can be collected with a minimally invasive needle probe and automatically analyzed using a computer neural network (CNN)-based AI software. The results can be conveyed to the clinician in real time and used to select the biopsy location more adequately. This technology was evaluated on a rabbit model of cancer. OCT images were collected with a hand-held custom-made OCT probe. Annotated OCT images were used as ground truth for AI algorithm training. The overall performance of the AI model was very close to that of the humans performing the same classification tasks. Specifically, tissue segmentation was excellent (~99% accuracy) and provided segmentation that closely mimicked the ground truth provided by the human annotations, while over 84% correlation accuracy was obtained for tumor and non-tumor classification.

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Low coherence interferometry approach for aiding fine needle aspiration biopsies

Cited by 7 publications

References 28 publications

Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans

Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans

Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

Core Needle Biopsy Guidance Based on Tissue Morphology Assessment with AI-OCT Imaging

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