Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome

Oruç, Coşkun Umut; Akpınar, Yunus Emre; Dervisoglu, Elmire; Amikishiyev, S.; Salmaslıoğlu, Artür; Gürdöl, Figen; Ömer, Beyhan

doi:10.1515/cclm-2016-0329

Cited by 27 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result suggests that the change in the serum adropin concentration may be one mechanism by which the exercise intervention improved vascular endothelial function in obese adolescents. Previous studies also demonstrated that a lower serum adropin level was associated with endothelial dysfunction using flow-mediated dilatation in patients with type-2 diabetes mellitus and metabolic syndrome 36 , 37 . Aerobic exercise training increased the serum adropin level and improved arterial stiffness and adiposity in obese adults 38 .…”

Section: Discussionmentioning

confidence: 83%

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Zhang

Jiang

Yang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Adropin is a secreted protein that regulates endothelial function. However, adropin levels in obese adolescent patients are currently uncertain. Therefore, we evaluated the association between plasma adropin levels and vascular endothelial function and investigated the effect of aerobic exercise in obese adolescents. A total of 45 obese adolescents and 20 controls (age 16–19 years) were included in our study. The obese adolescents received 12 weeks of aerobic exercise training. Serum adropin was detected using enzyme-linked immunosorbent assay. Vascular reactive hyperemia indexes (RHIs) were obtained using Endo-PAT2000. Adropin levels and RHI were significantly lower in obese adolescents than in normal-weight adolescents. Adropin levels and RHI increased significantly independently of changes in body weight after an exercise intervention (P < 0.01). Pearson correlation analysis revealed that adropin levels positively correlated with HDL-C levels (r = 0.389, P < 0.01) and RHI (r = 0.32, P < 0.01). Multiple linear stepwise regression analysis showed that the insulin resistance index (t = −3.301, P < 0.01) and HDL-C level (t = 2.620, P = 0.011) were independent risk factors of adropin levels. In addition, Δadropin (t = 3.261, P < 0.01) was an independent influencing factor of ΔRHI. Our findings suggest that adropin plays an important role in vascular endothelial function in obese adolescents.

show abstract

Section: Discussionmentioning

confidence: 83%

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Zhang

Jiang

Yang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has also been shown that adropin can regulate the expression of hepatic lipid synthesis genes [8]. In addition, a large number of population studies confirmed that the serum levels of adropin were negatively correlated with the risk factors of metabolic diseases [14], [15], [16]. However, adropin's role in regulating nonalcoholic steatohepatitis was still unclear.…”

Section: Discussionmentioning

confidence: 99%

Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity

et al. 2019

View full text Add to dashboard Cite

Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced NASH mice. Adropin knock-out mice and palmitate treated primary hepatic cells were used to investigate the influence of adropin on liver injury. Our results show that serum adropin levels were decreased and negatively correlated with liver injury in NASH mice. Knockout of adropin significantly exacerbated hepatic steatosis, inflammatory responses and fibrosis in mice after either methionine-choline deficient diet (MCD) or western diet (WD) feeding. And the treatment with adropin bioactive peptides ameliorated NASH progression in mice. Adropin alleviated hepatocyte injury by upregulating the expression of Gclc, Gclm, and Gpx1 in a manner dependent on Nrf2 transcriptional activity and by increasing the glutathione (GSH) levels. And adropin significantly increased CBP expression and promoted its binding with Nrf2, which enhanced Nrf2 transcriptional activity. Furthermore, AAV8-mediated overexpression of hepatic Nrf2 expression functionally restored the liver injury induced by adropin-deficiency MCD-fed mice. These findings provide evidence that adropin activates Nrf2 signaling and plays a protective role in liver injury of NASH and therefore might represent a novel target for the prevention and treatment of NASH.

show abstract

“…Low serum adropin levels are associated with reduced NO bioavailability in the endothelium, which is associated with the endothelial dysfunction (ED) that is predictor of atherosclerosis 30 . In a study of 110 patients with MetS, reduced serum adropin levels were associated with ED and with flow‐mediated dilatation (FMD) 31 …”

Section: Adropin Regulates Biological Pathways That Are Directly or Imentioning

confidence: 99%

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

2020

View full text Add to dashboard Cite

Adropin is a peptide hormone, which plays a role in energy homeostasis and controls glucose and fatty acid metabolism. Its levels correlate with changes in carbohydratelipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. Both metabolic pathways and adropin are regulated by the circadian clocks. Here, we review the roles of the autonomic nervous system and circadian rhythms in regulating metabolic pathways and energy homeostasis. The beneficial effects of chronotherapy in various systems are discussed. We suggest a potential role for adropin as a mediator of the metabolic system-autonomic nervous system axis. We discuss the possibility of establishing an individualized adropin and circadian rhythm-based platform for implementing chronotherapy, and variability signatures for improving the efficacy of adropin-based therapies are discussed. K E Y W O R D S adropin, autonomic nervous system, chronobiology, metabolic syndrome 1 | INTRODUCTION Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular complications, which increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). 1 The pathogenesis of MetS involves multiple factors, including the autonomic nervous system (ANS) and the circadian rhythm. 2 Recently, MetS was also shown to increase the risk and mortality of cancer, 3 with which it shares many risk factors including age, genetic factors, obesity, physical inactivity, unhealthy diet, alcohol, smoking, endocrine disruptors exposure and air pollution. Recent studies have suggested that several peptide hormones play important roles in the modulation of systemic metabolism and energy homeostasis. Adropin is a product of the energy homeostasis associated (Enho) gene and a peptide hormone that plays a role in the regulation of energy homeostasis and controls glucose and fatty acid metabolism. It was originally described as a secreted peptide, with

show abstract

Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome

Abstract: Low adropin level in circulation is related to ED and has a close association with FMD. Any alterations in its level may be of help in order to assess the development of ED before the occurrence of clinical symptoms in patients with metabolic syndrome.

Cited by 27 publications

References 28 publications

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

Contact Info

Product

Resources

About