Low Correlation Between PCWP and LVEDP in Patients With End-Stage Lung Disease

"Jerk Analysis Facilitates Automated LVEDP Extraction from Catheter Measurements and Offers Valve Actuation Functions as New CHF Markers"

“…Measuring PAP and LAP (or it's proxy PCWP) directly with micro-manometer catheters (pressure transducers), or implantable devices as CardioMEMS (Atlanta, GA) and Vectorious (Tel Aviv, Israel) helps to predict CHF, as pulmonary hypertension is a major chronic disease associated with CHF [4]. LAP and/or PCWP could serve as marker for left ventricle diastolic dysfunction, which is highly connected to CHF, however, it is not exactly an equivalent to LVEDP being the exact marker for left ventricle diastolic dysfunction [5,6] Despite the wide usage of L/RVEDP in heart catheterization, the exact definition presuming the reliable fully automated calculation of L/RVEDP without manual time alignment of the monitor display in the course of catheterization, was not previously presented. For example, in [8] LVEDP is defined as the measured LV pressure at the nadir of the atrial contraction wave before the onset of a rapid rise in left ventricular systolic pressure, or at the peak of R-wave on ECG which may not be properly observed, or can be poorly synchronized.…”