Low-cost and rapid prototyping of integrated electrochemical microfluidic platforms using consumer-grade off-the-shelf tools and materials

Asri, Mohd Afiq Mohd; Mak, Wing Cheung; Norazman, Siti Azizah; Nordin, Anis Nurashikin

doi:10.1039/d1lc01100f

Cited by 11 publications

(5 citation statements)

References 86 publications

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“…The 3D-printed structure was then stacked on a silicon sensor, and the adhesive was cured under UV light to achieve bonding [25]. Additionally, solid adhesives are also commonly used in microfluidic systems integrating sensors [70][71][72]. For instance, person R and others [73]enhanced the wettability contrast at the virtual wall by selectively making the adhesive tape superhydrophilic through adding hydrophobic silica gel.…”

Section: Adhesive-based Gluingmentioning

confidence: 99%

Microfluidic biosensors: exploring various applications through diverse bonding methods

Yang,

Zhu

2024

J. Micromech. Microeng.

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Biological sensors are widely applied in agriculture, biomedicine, food, healthcare, environmental monitoring, water quality, forensics, drug development, etc.. Particularly the utilization of microfluidic technology has become prevalent in the development and manufacturing of biosensors for miniaturization, automation, and integration. Microfluidic biosensors have distinct advantages, including enhanced diffusive timescales, controlled concentration gradients, high throughput, high precision fluid manipulation, stable reaction environments and high sensitivity. From the perspective of sensor fabrication, bonding remains the crucial pathway in the pursuit of integrating microfluidic technology with biosensor chips, while various bonding methods are employed across different application domains. This paper delves into the classification, progress, and challenges associated with these bonding methods corresponding with various microfluidic biosensors in diverse applications. The review presented herein highlights the latest advancements in microfluidic biosensors based on diverse bonding methods, underscoring their significant application prospects and developmental potential within these fields.

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Section: Adhesive-based Gluingmentioning

confidence: 99%

Microfluidic biosensors: exploring various applications through diverse bonding methods

Yang,

Zhu

2024

J. Micromech. Microeng.

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“…While EDL sensors demonstrate high sensitivity and range, factors such as ambient temperature, humidity, and external mechanical stress could potentially influence their performance. As such, calibration protocols and error correction methods should be established to ensure the accuracy and reliability of measurements [ 77 , 85 ]. Finally, while the use of EDL sensors in drug delivery is promising, the control of drug release based on electrical fields is a complex task.…”

Section: Applications Of Epidermal Electronics In Diagnosis and Thera...mentioning

confidence: 99%

“…Enables detection of hydrogen peroxide and glucose [85] Drug delivery Anodized aluminum oxide film, Cr-Au-Cr layer Realization of intelligent molecular flow control using field effect gating to achieve regulation of drug delivery rates [86]…”

Section: Bioinspired-materialsmentioning

confidence: 99%

Electric Double Layer Based Epidermal Electronics for Healthcare and Human-Machine Interface

et al. 2023

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Epidermal electronics, an emerging interdisciplinary field, is advancing the development of flexible devices that can seamlessly integrate with the skin. These devices, especially Electric Double Layer (EDL)-based sensors, overcome the limitations of conventional electronic devices, offering high sensitivity, rapid response, and excellent stability. Especially, Electric Double Layer (EDL)-based epidermal sensors show great potential in the application of wearable electronics to detect biological signals due to their high sensitivity, fast response, and excellent stability. The advantages can be attributed to the biocompatibility of the materials, the flexibility of the devices, and the large capacitance due to the EDL effect. Furthermore, we discuss the potential of EDL epidermal electronics as wearable sensors for health monitoring and wound healing. These devices can analyze various biofluids, offering real-time feedback on parameters like pH, temperature, glucose, lactate, and oxygen levels, which aids in accurate diagnosis and effective treatment. Beyond healthcare, we explore the role of EDL epidermal electronics in human-machine interaction, particularly their application in prosthetics and pressure-sensing robots. By mimicking the flexibility and sensitivity of human skin, these devices enhance the functionality and user experience of these systems. This review summarizes the latest advancements in EDL-based epidermal electronic devices, offering a perspective for future research in this rapidly evolving field.

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“…These technologies typically cover dimensions ranging from hundreds of micrometers to centimeters, sufficient for many integrated electrodes' applications with pumpless liquid transport and limited multiplexing. Foils of functional electrode materials and adhesives were cut for layer-by-layer assembly using a knife plotter [29]. A larger scale, automated setups, i.e.…”

Section: Design and Fabrication Of Microfluidics Integrated With Elec...mentioning

confidence: 99%

Microfluidic devices for photo-and spectroelectrochemical applications

Bogdanowicz

Jönsson-Niedziółka

Vereshchagina

et al. 2022

Current Opinion in Electrochemistry

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Low-cost and rapid prototyping of integrated electrochemical microfluidic platforms using consumer-grade off-the-shelf tools and materials

Abstract: Fabrication of laminated microfluidic devices with integrated electrochemical sensors using off-the-shelf tools and materials.

Cited by 11 publications

References 86 publications

Microfluidic biosensors: exploring various applications through diverse bonding methods

Microfluidic biosensors: exploring various applications through diverse bonding methods

Electric Double Layer Based Epidermal Electronics for Healthcare and Human-Machine Interface

Microfluidic devices for photo-and spectroelectrochemical applications

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