Low-cost, automated reaction screening for energetic precursor cage compounds by a benchtop liquid handling robot and desorption electrospray ionization mass spectrometry

Abstract

High-throughput reaction screening by mass spectrometry (MS) enables detection of multiple analytes simultaneously without tagging, permitting the starting materials, intermediates, and products to be detected and identified concurrently. Presented here,...

A modular low-cost automated synthesis machine demonstrated by ring-opening metathesis polymerization

“…The high cost presents a challenge for researchers seeking an entrance to automation, thus leading research groups to use either the few basic low-cost syntheses assisting systems available e.g. micro pipetting in limited solvents, [27][28][29][30] or to build customized synthesis equipment targeting specific reactions. [31][32][33] Although advanced synthesis automation equipment is available the focus is mainly on specific chemistry and yield optimization from machine learning, rather than the practical aspects of automation equipment.…”