Low-cost, multimodal, portable screening system for early detection of oral cancer

Rahman, Mohammed; Chaturvedi, Pankaj; Gillenwater, Ann M.; Richards‐Kortum, Rebecca

doi:10.1117/1.2907455

Cited by 48 publications

(29 citation statements)

References 11 publications

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“…In May 2008, the same Journal published a work on a new device based on the same principle: the improvements are given by easier transportability, binocular sight, and its combination with a video recording system. 22 …”

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confidence: 97%

Autofluorescence and Early Detection of Mucosal Lesions in Patients at Risk for Oral Cancer

Moro

Nardo

Boniello

et al. 2010

Journal of Craniofacial Surgery

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Loss of autofluorescence as an early phenomenon associated with tissue degeneration seems to be promising for the diagnosis of oral cancer. The method seems to make visible early structural and biochemical alterations of the oral mucosa not always evident under direct inspection of the oral cavity. For this reason, the margins of the mucosal lesions usually appear wider compared with direct visualization. Actual extension of the potentially malignant lesions must be precisely perceived to avoid any underestimation of the tumor. In this study, 32 patients at risk for oral cancer underwent autofluorescence test. Of these patients, 12 (group A) experienced potentially malignant diseases. The other 20 patients (group B) were previously operated on for oral cancer. In addition, 13 patients showed loss of autofluorescence (8 patients from group A and 5 patients from group B). Among these 13 patients, 12 were affected with lesions of relevance (in group A, 6 had squamocellular carcinoma and 2 had low-grade dysplasia; in group B, 2 patients had high-grade dysplasia, 2 had low-grade dysplasia, and 1 had an epithelial hypertrophy with inflammatory cells). Preliminary results seem to indicate that autofluorescence is a high-performing test for the individuation of oral cancer in populations at risk (sensibility up to 100% and specificity up to 93% in this study).

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confidence: 97%

Autofluorescence and Early Detection of Mucosal Lesions in Patients at Risk for Oral Cancer

Moro

Nardo

Boniello

et al. 2010

Journal of Craniofacial Surgery

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“…13 As these parameters change with disease progression, optical spectroscopy provides an alternative to detect disease progression in an objective and noninvasive way. Cancer detection using optical spectroscopy has been reported for a variety of tissues such as bladder, 14,15 breast, 16,17 oral cavity, 18 cervix, 19 coronary arteries, 20,21 Barrett's esophagus, 22 and skin. 23,24 Several commercial efforts have developed optical-based products that perform noninvasive melanoma skin cancer (MSC) diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

et al. 2014

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Abstract. The goal of this study was to determine the diagnostic capability of a multimodal spectral diagnosis (SD) for in vivo noninvasive disease diagnosis of melanoma and nonmelanoma skin cancers. We acquired reflectance, fluorescence, and Raman spectra from 137 lesions in 76 patients using custom-built optical fiber-based clinical systems. Biopsies of lesions were classified using standard histopathology as malignant melanoma (MM), nonmelanoma pigmented lesion (PL), basal cell carcinoma (BCC), actinic keratosis (AK), and squamous cell carcinoma (SCC). Spectral data were analyzed using principal component analysis. Using multiple diagnostically relevant principal components, we built leave-one-out logistic regression classifiers. Classification results were compared with histopathology of the lesion. Sensitivity/specificity for classifying MM versus PL (12 versus 17 lesions) was 100%/100%, for SCC and BCC versus AK (57 versus 14 lesions) was 95%/71%, and for AK and SCC and BCC versus normal skin (71 versus 71 lesions) was 90%/85%. The best classification for nonmelanoma skin cancers required multiple modalities; however, the best melanoma classification occurred with Raman spectroscopy alone. The high diagnostic accuracy for classifying both melanoma and nonmelanoma skin cancer lesions demonstrates the potential for SD as a clinical diagnostic device.

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“…[1][2][3][4][5] In human tissue, LIFS is used to determine the tissue's endogenous fluorophore content, such as the relative amounts of nicotinamide adenine dinucleotide (NADH), collagen, and flavin adenine dinucleotide (FAD). NADH and FAD are byproducts of metabolic activities, and significant changes in NADH and FAD fluorescence could serve as a noninvasive indicator of tumor growth in vivo.…”

Section: Introductionmentioning

confidence: 99%

Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements

et al. 2011

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Abstract. Diffuse reflectance and fluorescence spectroscopy are popular research techniques for noninvasive disease diagnostics. Most systems include an optical fiber probe that transmits and collects optical spectra in contact with the suspected lesion. The purpose of this study is to investigate probe pressure effects on human skin spectroscopic measurements. We conduct an in-vivo experiment on human skin tissue to study the short-term (<2 s) and long-term (>30 s) effects of probe pressure on diffuse reflectance and fluorescence measurements. Short-term light probe pressure (P0 < 9 mN/mm 2 ) effects are within 0 ± 10% on all physiological properties extracted from diffuse reflectance and fluorescence measurements, and less than 0 ± 5% for diagnostically significant physiological properties. Absorption decreases with site-specific variations due to blood being compressed out of the sampled volume. Reduced scattering coefficient variation is site specific. Intrinsic fluorescence shows a large standard error, although no specific pressure-related trend is observed. Differences in tissue structure and morphology contribute to site-specific probe pressure effects. Therefore, the effects of pressure can be minimized when the pressure is small and applied for a short amount of time; however, long-term and large pressures induce significant distortions in measured spectra. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Low-cost, multimodal, portable screening system for early detection of oral cancer

Cited by 48 publications

References 11 publications

Autofluorescence and Early Detection of Mucosal Lesions in Patients at Risk for Oral Cancer

Autofluorescence and Early Detection of Mucosal Lesions in Patients at Risk for Oral Cancer

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements

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