Low-cost paper-based electrochemical sensor for the detection of ciprofloxacin in honey and milk samples

Souza, Cassiano Cunha de; Alves, Guilherme Figueira; Lisboa, Thalles Pedrosa; Matos, Maria Auxiliadora Costa; Matos, Renato Camargo

doi:10.1016/j.jfca.2022.104700

Cited by 29 publications

(7 citation statements)

References 26 publications

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“…Alternatively, electrochemical methods – have demonstrated outstanding advantages, such as reduced costs, simple operations, short response times, and high sensitivities. Therefore, electrochemical methods, such as voltammetry, have been adopted for the trace detection of fluoroquinolone antibiotics. – However, the bare electrodes usually suffer from a poor sensitivity toward LEV due to the sluggish electron-transfer process . To address this issue, electrocatalysts based on noble metal nanoparticles (NPs), – conducting polymers, – metal–organic frameworks (MOFs), , graphene, and graphene derivatives – have been used to modify glassy carbon electrodes (GCEs) to promote electron transfer and enhance the sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin

Li,

Wan,

Xia

et al. 2023

ACS Appl. Nano Mater.

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The excessive use of levofloxacin (LEV) can lead to significant environmental pollution, while also damaging human health. The accurate detection of its concentration is therefore essential to protect both the environment and human health. Herein, we report the simple synthesis of α-zirconium phosphate supported on nitrogen-doped graphene nanosheets (α-ZrP/NG) and its application in the voltammetric determination of trace LEV in real samples. The surface morphology, microstructure, and electrochemical properties of α-ZrP/NG were investigated by microscopic and spectroscopic techniques. The analytical parameters, including the accumulation potential, accumulation time, loading volume, and buffer pH, were optimized to improve the electrocatalytic sensing performance of α-ZrP/NG. Owing to the synergetic interaction between α-ZrP and NG, the proposed sensor exhibited an excellent electrocatalytic activity for the electrical oxidation of LEV. In the range of 0.01−5.0 μM, the anodic peak current of LEV increased linearly with an increase in the LEV concentration, and the limit of detection was 2.6 nmol L −1 . Finally, the LEV levels in wastewater, human serum, milk, and eye drop samples were determined by using the α-ZrP/NG system combined with a glassy carbon electrode to give satisfactory recoveries (98.48−103.2%), indicating that the prepared sensor demonstrates promise for use in environmental, food, and drug monitoring applications.

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Section: Introductionmentioning

confidence: 99%

Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin

Li,

Wan,

Xia

et al. 2023

ACS Appl. Nano Mater.

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“…Related to SPEs is a report that uses a paper-based electrochemical sensor for the sensing of ciprofloxacin and exhibited a linear range from 9.90-220 μM with a LOD reported to be 4.96 μM. 35 This sensor was fabricated by taking graphite powder, which was mixed with nail polish diluted within acetone. This was homogenized and placed onto a paper substrate, which was dried in the oven to remove the solvent.…”

Section: Differential Pulse and Square-wave Voltammetrymentioning

confidence: 99%

“…Interestingly, the authors demonstrated their sensor could measure ciprofloxacin within spiked milk and honey by simply diluting the milk sample by 10-fold with water, while the honey was dissolved into water with the recoveries were 84–93%. 35…”

Section: Electroanalytical Based Sensors For Ciprofloxacinmentioning

confidence: 99%

Electroanalytical overview: the measurement of ciprofloxacin

Crapnell,

Adarakatti,

Banks

2024

Sens. Diagn.

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“…Similar to pesticides, there are maximum residue levels (MRLs) set for veterinary drugs (including active substances and their metabolites) in food [ 102 ]. To date, only a few papers have reported the development of e-PADs for veterinary drug determination, all of which target antibiotic detection in milk samples [ 83 , 103 ]. Majority of reported e-PADs deployed optical detection methods such as colorimetry [ 104 , 105 , 106 , 107 ] and fluorescence [ 108 , 109 , 110 , 111 ].…”

Section: Applications For Food Safetymentioning

confidence: 99%

“…Many drugs are electroactive and therefore can be electrochemically detected via direct oxidation/reduction [ 37 , 112 , 113 ]. Direct oxidation has been applied to detect ciprofloxacin and sulfanilamide in milk using e-PADs [ 83 , 114 ]. Milk samples were diluted in deionized water or buffer and then subjected to electrochemical measurements.…”

Section: Applications For Food Safetymentioning

confidence: 99%

Paper-Based Electrochemical Biosensors for Food Safety Analysis

2022

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Nowadays, foodborne pathogens and other food contaminants are among the major contributors to human illnesses and even deaths worldwide. There is a growing need for improvements in food safety globally. However, it is a challenge to detect and identify these harmful analytes in a rapid, sensitive, portable, and user-friendly manner. Recently, researchers have paid attention to the development of paper-based electrochemical biosensors due to their features and promising potential for food safety analysis. The use of paper in electrochemical biosensors offers several advantages such as device miniaturization, low sample consumption, inexpensive mass production, capillary force-driven fluid flow, and capability to store reagents within the pores of the paper substrate. Various paper-based electrochemical biosensors have been developed to enable the detection of foodborne pathogens and other contaminants that pose health hazards to humans. In this review, we discussed several aspects of the biosensors including different device designs (e.g., 2D and 3D devices), fabrication techniques, and electrode modification approaches that are often optimized to generate measurable signals for sensitive detection of analytes. The utilization of different nanomaterials for the modification of electrode surface to improve the detection of analytes via enzyme-, antigen/antibody-, DNA-, aptamer-, and cell-based bioassays is also described. Next, we discussed the current applications of the sensors to detect food contaminants such as foodborne pathogens, pesticides, veterinary drug residues, allergens, and heavy metals. Most of the electrochemical paper analytical devices (e-PADs) reviewed are small and portable, and therefore are suitable for field applications. Lastly, e-PADs are an excellent platform for food safety analysis owing to their user-friendliness, low cost, sensitivity, and a high potential for customization to meet certain analytical needs

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Low-cost paper-based electrochemical sensor for the detection of ciprofloxacin in honey and milk samples

Cited by 29 publications

References 26 publications

Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin

Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin

Electroanalytical overview: the measurement of ciprofloxacin

Paper-Based Electrochemical Biosensors for Food Safety Analysis

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