Low crosslinking imprinted coatings based on liquid crystal for capillary electrochromatography

Wei, Ze-Hui; Mu, Li-Na; Huang, Yanping; Liu, Zhao‐Sheng

doi:10.1016/j.chroma.2012.03.041

Cited by 39 publications

(22 citation statements)

References 45 publications

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“…A technique named dummy-imprinting, generally used for solving the problem of template leakage, has also shown potential for reducing consumption of template [16,17], using a cheap structural analogue of the target analyte to replace the targeted molecule during polymerization. Liquid-crystalline MIP can also be formed to improve the yield of binding sites [18,19], in which chemical crosslinking is partly replaced by the interaction of rigid mesogenic side-groups to avoid the use of a high level of crosslinker (usually approximately 80-90 %). In such liquid-crystalline systems, low levels of cross-linking in MIPs (5-20 mol % of the monomer units) are sufficient to imprint the memory of the template, and improved capacity can be achieved as a result of the enhanced site accessibility.…”

Section: Introductionmentioning

confidence: 99%

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Sun

Zhong

et al. 2015

Anal Bioanal Chem

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One of the main challenges in the preparation of molecularly imprinted polymers (MIPs) is the substantial initial amount of template needed because of the requirement of high load capacities for most applications. A new strategy of macromolecular crowding was suggested to solve this problem by reducing the amount of template in the polymerization recipe. In a ternary porogenic system of polystyrene (PS) (crowding agent), tetrahydrofuran, and toluene, an imprinted monolithic column with high porosity and good permeability was synthesized using a mixture of ellagic acid (template), acrylamide, and ethylene glycol dimethacrylate. The effect of polymerization factors, including monomer-template molar ratio and the molecular weight and concentration of PS, on the imprinting effect of the resulting MIP monoliths was systematically investigated. At a high ratio of monomer-template (120:1), the greatest imprinting factor of 32.4 was obtained on the MIP monolith with the aid of macromolecular crowding agent. The PS-based imprinted monolith had imprinting even at the extremely high ratio of functional monomer to template of 1510:1. Furthermore, an off-line solid-phase extraction based on the ground MIP was conducted, and the purification recovery of ellagic acid from pomegranate-rind extract was up to 80 %. In conclusion, this approach based on macromolecular crowding is simple, and is especially valuable for those applications of MIP preparation for which a rare template is used.

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Section: Introductionmentioning

confidence: 99%

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Sun

Zhong

et al. 2015

Anal Bioanal Chem

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“…Therefore, introducing liquid crystalline groups into MIPs can replace a part of the chemical cross‐linking (e.g., EDMA) by physical cross‐linking due to the interactions between the mesogens, which can ‘‘hold’’ polymeric chains and complementary functionalities together, preventing the collapsing of the binding sites and ensuring a recognition capacity to the material with more accessible sites. Wei et al successfully prepared low cross‐linking (20%) imprinted coatings using a liquid crystal monomer, 4‐methyl phenyl dicyclohexyl propylene. The resulting MIPs had similar selectivity but a much higher capacity compared with the classical MIPs.…”

Section: Organic Polymer‐based Mipsmentioning

confidence: 99%

“…Conditions: capillary, 100‐μm id, 41.5‐cm total length, and 30.0‐cm effective length; separation voltage, 25 kV; temperature, 25°C; UV‐Vis detector, 238 nm; ACN/10 mM acetate (pH 3.6; 80/20, v/v). Reprinted with permission from .…”

Section: Organic Polymer‐based Mipsmentioning

confidence: 99%

Current trends in the development of molecularly imprinted polymers in CEC

Wei

Liu

2015

Electrophoresis

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This review focused on the developments in the field of molecularly imprinted polymers (MIPs) for CEC since 2009. New preparation techniques of MIP-based CEC, such as, portable microchip with macroporous monolithic imprinted microchannel, and low cross-linking MIPs based on liquid crystalline monomers, were discussed. Using selected cases rather than a comprehensive review of the entire field, our goal is to highlight the studies of the interest with an emphasis on recent work, and offers suggestions for future development in the field of imprinted materials for CEC separation.

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“…Molecular imprinting technologies (MIT) have been widely applied in research areas such as sensors , chromatographic separation , mimics for biological receptors , and drug separation since the specific recognition to a certain target molecule . Molecularly imprinted polymers (MIPs) used for LC and CEC were proposed for recognition and enantioseparation of amlodipine. The conventional monolithic column prepared by in situ polymerization in stainless‐steel column typically has relatively poor site accessibility to ensure sufficient mass transfer, resulting in low column capacity.…”

Section: Introductionmentioning

confidence: 99%

“…The affinity of MIPs relies on not only heavy dosage of monomers, but also taking full advantage of template molecule for binding sites. Low cross‐linked imprinted polymers have showed positive effect on molecule recognition and indicated a strategy to improve the mass transfer.…”

Section: Introductionmentioning

confidence: 99%

Rapid and efficient enantioseparation of (S)‐amlodipine by surface‐imprinted core–shell polymer microspheres

Lai

Chen

Ouyang

et al. 2016

J of Separation Science

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We present a protocol for the preparation of surface-imprinted polymer microspheres by core-shell precipitation polymerization for the enantioseparation of (S)-amlodipine. In this work, submicron mesoporous silica microspheres were prepared with gemini cationic surfactant as soft template. Molecularly imprinted polymers were coated on the silica supports with a low level of crosslinking, and the thickness of the thin-walled imprinted shell was about 45 nm. The material showed fast binding kinetics for (S)-amlodipine (within only 20 min for complete equilibrium), and the saturation adsorption capacity reached 309.2 mg/g, indicating the good accessibility of binding sites and improved mass transfer for target molecule. The imprinted microspheres exhibited an appreciable enantiomeric excess of (S)-amlodipine of 11.3% when used as a glass chromatography column for the enantioseparation of (S)-amlodipine from amlodipine besylate without extra chiral additives. The surface-imprinted materials display potentially amplification for industrial enantioseparation of (S)-amlodipine.

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Low crosslinking imprinted coatings based on liquid crystal for capillary electrochromatography

Cited by 39 publications

References 45 publications

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Current trends in the development of molecularly imprinted polymers in CEC

Rapid and efficient enantioseparation of (S)‐amlodipine by surface‐imprinted core–shell polymer microspheres

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