Low cytotoxicity, antibacterial property, and curcumin delivery performance of toughness-enhanced electrospun composite membranes based on poly(lactic acid) and MAX phase (Ti3AlC2)

Krasian, Tharnthip; Punyodom, Winita; Molloy, Robert; Topham, Paul D.; Tighe, Brian J.; Mahomed, Anisa; Chaiwarit, Tanpong; Panraksa, Pattaraporn; Rachtanapun, Pornchai; Jantanasakulwong, Kittisak; Worajittiphon, Patnarin

doi:10.1016/j.ijbiomac.2024.129967

Cited by 6 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the interaction mechanisms of these nanomaterials may be more potent against fungi’s cell structures and reproductive mechanisms than bacteria. This specificity in antimicrobial activity underscores the significance of comprehending the intricate interactions between nanomaterials and various microorganisms for the advancement of targeted antimicrobial therapies ( Warsi et al, 2022 ; Krasian et al, 2024 ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Shahbaz,

Sabir,

Amin

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

MAX phases, characterized as nanolaminates of ternary carbides/nitrides structure, possess a unique combination of ceramic and metallic properties, rendering them pivotal in materials research. In this study, chromium aluminum carbide ternary compounds, Cr2AlC (211), Cr3AlC2 (312), and Cr4AlC3 (413) were successfully synthesized with high purity using a facile and cost-effective sol-gel method. Structural, morphological, and chemical characterization of the synthesized phases was conducted to understand the effects of composition changes and explore potential applications. Comprehensive characterization techniques including XRD for crystalline structure elucidations, SEM for morphological analysis, EDX for chemical composition, Raman spectroscopy for elucidation of vibrational modes, XPS to analyze elemental composition and surface chemistry, and FTIR spectroscopy to ensure the functional groups analysis, were performed. X-ray diffraction analysis indicated the high purity of the synthesized Cr2AlC phase as well as other ternary compounds Cr3AlC2 and Cr4AlC3, suggesting its suitability as a precursor for MXenes production. Additionally, the antimicrobial activity against Candida albicans and biocompatibility assessments against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and HepG2 cell line were investigated. The results demonstrated significant antifungal activity of the synthesized phases against Candida albicans and negligible impact on the viability of E. coli and S. aureus. Interestingly, lower concentrations of Cr2AlC MAX phase induced cytotoxicity in HepG2 cells by triggering intercellular oxidative stress, while Cr3AlC2 and Cr4AlC3 exhibited lower cytotoxicity compared to Cr2AlC, highlighting their potential in biomedical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Shahbaz,

Sabir,

Amin

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…Recently, a fast-dissolving electrospun polysaccharide fibrous film loaded with curcumin was fabricated for the fast delivery of curcumin in the mouth [ 18 ]. A polylactic acid-based electrospun composite material loaded with curcumin was reported to achieve antibacterial properties against E. coli and S. aureus [ 19 ]. An electrospun polyvinylpyrrolidone and soy protein composite encapsulating curcumin nanoparticles was reported to possess hemocompatibility and antipathogenic activities, and wound-healing potentials [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

Lin,

Li,

Huang

2024

Foods

View full text Add to dashboard Cite

Electrospun/sprayed fiber films and nanoparticles were broadly studied as encapsulation techniques for bioactive compounds. Nevertheless, many of them involved using non-volatile toxic solvents or non-biodegradable polymers that were not suitable for oral consumption, thus rather limiting their application. In this research, a novel electrospun lipid–polymer composite (ELPC) was fabricated with whole generally recognized as safe (GRAS) materials including gelatin, medium chain triglyceride (MCT) and lecithin. A water-insoluble bioactive compound, tetrahydrocurcumin (TC), was encapsulated in the ELPC to enhance its delivery. Confocal laser scanning microscopy (CLSM) was utilized to examine the morphology of this ELPC and found that it was in a status between electrospun fibers and electrosprayed particles. It was able to form self-assembled emulsions (droplets visualized by CLSM) to deliver active compounds. In addition, this gelatin-based ELPC self-assembled emulsion was able to form a special emulsion gel. CLSM observation of this gel displayed that the lipophilic contents of the ELPC were encapsulated within the cluster of the hydrophilic gelatin gel network. The FTIR spectrum of the TC-loaded ELPC did not show the fingerprint pattern of crystalline TC, while it displayed the aliphatic hydrocarbon stretches from MCT and lecithin. The dissolution experiment demonstrated a relatively linear release profile of TC from the ELPC. The lipid digestion assay displayed a rapid digestion of triglycerides in the first 3–6 min, with a high extent of lipolysis. A Caco-2 intestinal monolayer transport study was performed. The ELPC delivered more TC in the upward direction than downwards. MTT study results did not report cytotoxicity for both pure TC and the ELPC-encapsulated TC under 15 μg/mL. Caco-2 cellular uptake was visualized by CLSM and semi-quantified to estimate the accumulation rate of TC in the cells over time.

show abstract

Sol-gel derived ternary CrxCuCx-1 compounds: Characterization, structural insights and biological properties

Shahbaz,

Ishfaq,

Sabir

et al. 2024

Journal of Molecular Structure

View full text Add to dashboard Cite

Low cytotoxicity, antibacterial property, and curcumin delivery performance of toughness-enhanced electrospun composite membranes based on poly(lactic acid) and MAX phase (Ti3AlC2)

Cited by 6 publications

References 53 publications

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

Sol-gel derived ternary CrxCuCx-1 compounds: Characterization, structural insights and biological properties

Contact Info

Product

Resources

About