Low dehydroepiandrosterone circulating levels in premenopausal obese women with very high body mass index

Pergola, Giovanni De; Giagulli, Vito Angelo; Garruti, Gabriella; Cospite, M; Giorgino, Francesco; Cignarelli, Mauro; Giorgino, R

doi:10.1016/0026-0495(91)90172-s

Cited by 62 publications

(36 citation statements)

References 19 publications

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“…In the female population, in spite of the abundance of available data on abdominal obesity and increases in androgenicity, studies on DHEA-S are not numerous, and the relationship with abdominal fat distribution is unclear. Although previous studies found no relationship between these two measures in obese women (46), the present data indicate that DHEA-S correlates inversely with WHR and the conicity index. Furthermore, the correlation with abdominal fat distribution was contrary to that observed with other androgens.…”

Section: Discussioncontrasting

confidence: 99%

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Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones

et al. 2000

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Objective: To correlate anthropometric, computed tomography and fat cell data from abdominal regions with the levels of serum insulin, C-peptide, leptin, tumor necrosis factor-alpha (TNF-a), testosterone, 17b-estradiol, androstenedione, dehydroepiandrosterone sulphate (DHEA-S) and sex hormone-binding globulin (SHBG). Design and methods: The sample consisted of 84 obese patients (29 men, 22 premenopausal women and 33 postmenopausal women) who had undergone abdominal surgery. Weight, height, percentage of body fat by skinfolds, waist, hip and thigh circumferences, sagittal and coronal diameters, visceral and subcutaneous area, serum hormones and fat cell data were studied. Results and conclusions: Premenopausal women showed the lowest values in most abdominal distribution parameters, although, depending on the waist circumference criteria at the umbilicus level perimeter (W1) or midway between lower rib margin and iliac crest perimeter (W2), the population was classi®ed differently, as gynoid or android. Although there were no differences in fat cell size between genders, gynoid women had smaller and more numerous fat cells than the android type. Perivisceral fat cell size was signi®cantly smaller than subcutaneous fat cell size. In women, central obesity was signi®cantly correlated with an increase in serum insulin, leptin, TNF-a, testosterone and androstenedione levels, and a decrease in 17b-estradiol and DHEA-S, while in men signi®cant correlations were positive with insulin and negative with testosterone and androstenedione. Fat cell size was positively correlated with serum levels of leptin, insulin, DHEA-S, androstenedione and inversely correlated with SHBG. These data indicate that hormones seem to interact not only with body fat distribution but also with fat cell size. This interaction differs between genders and between the different abdominal adipose tissue regions.

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Section: Discussioncontrasting

confidence: 99%

“…Plasma levels of DHEA-S in the obese population studied were low, especially in premenopausal women and in men, and lower than those found in the normalweight population (46). Different authors have previously found that DHEA and its sulphate have a thermogenic and antiobesity effect (47).…”

Section: Discussionmentioning

confidence: 69%

Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones

et al. 2000

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“…The common belief, therefore, is that maleness with excess androgens is associated with central obesity. While hyperandrogenicity is a signi®cant contributor to increased central adiposity in women, 11,29,30 it is clearly not so in men. Instead, testosterone levels are lower in men with increased abdominal girth or WHR compared to age-matched, non-obese men.…”

Section: Discussionmentioning

confidence: 99%

Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men

et al. 2000

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OBJECTIVE: To examine the association between baseline testosterone levels and changes in visceral adiposity in Japanese-American men. DESIGN: Prospective observational study. SUBJECTS: Second-generation Japanese-American males enrolled in a community-based population study. MEASUREMENTS: At baseline, 110 men received a 75 g oral glucose tolerance test (OGTT), and an assessment of body mass index (BMI); visceral adiposity measured as intra-abdominal fat area (IAF) using computed tomography (CT); fasting insulin and C-peptide levels; and total testosterone levels. IAF was re-measured after 7.5 y. Subcutaneous fat areas were also measured by CT in the abdomen, thorax and thigh. The total fat (TF) was calculated as the sum of IAF and total subcutanous fat areas (SCF). RESULTS: After 7.5 y, IAF increased by a mean of 8.0 cm 2 (95% CI: 0.8, 15.3). Baseline total testosterone was signi®cantly correlated with change in IAF (r À0.26, P 0.006), but not to any appreciable degree with change in BMI, TF, or SCF. In a linear regression model with change in IAF as the dependent variable, baseline testosterone was signi®cantly related to this outcome while adjusting for baseline IAF, SCF, BMI, age, diabetes mellitus status (OGTT by the WHO diagnostic criteria) and fasting C-peptide (regression coef®cient for baseline testosterone [nmolal] À107.13, P 0.003). CONCLUSIONS: In this Japanese-American male cohort, lower baseline total testosterone independently predicts an increase in IAF. This would suggest that by predisposing to an increase in visceral adiposity, low levels of testosterone may increase the risk of type 2 diabetes mellitus.

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“…In contrast, in adult men with obesity (22) and hyperinsulinaemia (23,24) DHEA(S) is decreased. Levels of dehydroepiandrosterone or DHEAS are similarly reduced in women with severe obesity or type 2 diabetes (25,26).…”

Section: Introductionmentioning

confidence: 92%

Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche

l’Allemand

Schmidt

Rousson

et al. 2002

European Journal of Endocrinology

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Objective: To explain why adrenal androgens rise with increasing adiposity during childhood, the role of body mass index (BMI), leptin and IGF-I was studied. We also tested whether these parameters contribute to inducing premature adrenarche (PA). Design: In a cross-sectional study, 26 prepubertal obese children were compared with a group of 26 prepubertal children of normal weight, and 30 children under observation for PA were compared with 30 healthy children, matched for gender, bone age and BMI. Methods: Relative contributions of BMI standard deviation scores (SDS) and height SDS, as well as unbound leptin and IGF-I, to the levels of androgens, dehydroepiandrosterone sulfate (DHEAS) and D4-androstenedione (AD) were investigated by means of stepwise regression models. Logarithms of all hormones were standardised for age using residuals of a simple regression analysis, labelled by the suffix ' res '. Results: In the obese children, height SDS, IGF-I res, DHEAS res (all P , 0:05), leptin res ðP , 0:01Þ; and AD res ðP ¼ 0:07Þ were higher than in the controls, and covariates were correlated with each other (leptin res versus BMI SDS r ¼ 0:71; IGF-I res versus height SDS r ¼ 0:61). In the stepwise regression analysis of control and obese children, BMI SDS explained 26% and leptin res explained 12% of the variability of DHEAS res , but this percentage remained at 26% when both variables were simultaneously introduced into the model. In contrast, IGF-I res and BMI SDS alone each accounted for 15% of the variability of AD, and their joint influence accumulated to explain 28% of the variability of AD res . In PA, neither BMI SDS nor leptin res were correlated with the increased androgens. Conclusion: Before the onset of gonadal activity in obese and control children, DHEAS levels, to some extent, are explained by BMI and leptin, while IGF-I in addition to BMI in part accounts for AD levels. Enhanced adrenal androgen secretion in children with PA, however, may be explained by parameters other than leptin or BMI.

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Low dehydroepiandrosterone circulating levels in premenopausal obese women with very high body mass index

Cited by 62 publications

References 19 publications

Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones

Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones

Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men

Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche

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