Low-density lipoprotein receptor-related protein 1 regulates muscle fiber development in cooperation with related genes to affect meat quality

Lv, Chao; Niu, Shichao; Yan, Shouqing; Bai, Chen; Yu, Xi; Hou, Jiani; Gao, Wenjing; Zhang, Jinyu; Zhao, Zhihui; Yang, Caini; Zhang, Yonghong

doi:10.3382/ps/pez168

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Many core genes and protein families have significant regulatory effects on the composition, energy metabolism and quantity of muscle fibers (Sun et al, 2019;Zhao et al, 2020;Feng et al, 2019). The muscle fiber difference between Lonchura striata and Copsychus saularis may result from different levels of gene regulation, which makes the characteristics of muscle fibers more adapted to the living habits of the corresponding species (Lv et al, 2019;Lang et al, 2020). There are differences in feeding habits and habits between the two birds.…”

Section: Differences In Histological Characteristics Of Muscle Fibers...mentioning

confidence: 99%

Comparison of the Structure of Leg and Pectoral Muscles between Lonchura striata and Copsychus saularis

Liu

Zhang

et al. 2022

IJAR

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Background: Bird is important in maintaining biodiversity and its lifestyles and behaviors will pose an important impact on the ecological environment. Birds are also inseparable for ecological stability. Birds’ movement and living habits are a widely studied topic. Methods: Two economic valuable birds, Lonchura striata and Copsychus saularis, were selected in this study. It aims at investigating the characteristics of muscle fiber tissues and comparing the differences between male and female species. Histological techniques were used to determine the characteristics of the muscle fiber (diameter, area and density) in leg and pectoral muscles. Result: There were differences in the muscle fiber characteristics of the Lonchura striata and the Copsychus saularis. The characteristics of muscle fibers between males and females of the same species were significantly different and there were also significant differences in the same parts of different species. The diameter and area of muscle fibers are correlated to the density of muscle fibers. This study suggested that the characteristics of muscle fibers are related to their living habits and population characteristics.

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Section: Differences In Histological Characteristics Of Muscle Fibers...mentioning

confidence: 99%

Comparison of the Structure of Leg and Pectoral Muscles between Lonchura striata and Copsychus saularis

Liu

Zhang

et al. 2022

IJAR

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“…The second pleiotropic region on BTA5 (56.2-56.9 Mb) harbors three candidate genes involved in lipid metabolism and muscle development, namely Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1), Myosin 1A (MYO1A), and Nascent Polypeptide-Associated Complex Alpha Subunit (NACA). The LRP1 gene plays important roles in many cellular and biological processes, including cell growth and lipid metabolism (Dato and Chiabrando, 2018), and regulates muscle fiber development and myoblast proliferation (Lv et al, 2019). MYO1A is a well-known gene related to muscle development, whereas the NACA gene is involved in the regulation and differentiation of myoblast cells and myogenic lineages (Berger et al, 2012), and lipid metabolism (Cui et al, 2012).…”

Section: Genes Within Pleiotropic Regionsmentioning

confidence: 99%

“…The highlighted candidate genes regulate muscle development, myoblast proliferation, and lipid metabolism. In addition to the obvious effect on MARB and REA, these genes could also affect TEND, TEXT and FIRM given the impact of muscle fiber diameter and density on these traits (Pearson, 1990;Lv et al, 2019).…”

Section: Genes Within Pleiotropic Regionsmentioning

confidence: 99%

Genomic Approaches Reveal Pleiotropic Effects in Crossbred Beef Cattle

et al. 2021

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Carcass and meat quality are two important attributes for the beef industry because they drive profitability and consumer demand. These traits are of even greater importance in crossbred cattle used in subtropical and tropical regions for their superior adaptability because they tend to underperform compared to their purebred counterparts. Many of these traits are challenging and expensive to measure and unavailable until late in life or after the animal is harvested, hence unrealistic to improve through traditional phenotypic selection, but perfect candidates for genomic selection. Before genomic selection can be implemented in crossbred populations, it is important to explore if pleiotropic effects exist between carcass and meat quality traits. Therefore, the objective of this study was to identify genomic regions with pleiotropic effects on carcass and meat quality traits in a multibreed Angus–Brahman population that included purebred and crossbred animals. Data included phenotypes for 10 carcass and meat quality traits from 2,384 steers, of which 1,038 were genotyped with the GGP Bovine F-250. Single-trait genome-wide association studies were first used to investigate the relevance of direct additive genetic effects on each carcass, sensory and visual meat quality traits. A second analysis for each trait included all other phenotypes as covariates to correct for direct causal effects from identified genomic regions with pure direct effects on the trait under analysis. Five genomic windows on chromosomes BTA5, BTA7, BTA18, and BTA29 explained more than 1% of additive genetic variance of two or more traits. Moreover, three suggestive pleiotropic regions were identified on BTA10 and BTA19. The 317 genes uncovered in pleiotropic regions included anchoring and cytoskeletal proteins, key players in cell growth, muscle development, lipid metabolism and fat deposition, and important factors in muscle proteolysis. A functional analysis of these genes revealed GO terms directly related to carcass quality, meat quality, and tenderness in beef cattle, including calcium-related processes, cell signaling, and modulation of cell–cell adhesion. These results contribute with novel information about the complex genetic architecture and pleiotropic effects of carcass and meat quality traits in crossbred beef cattle.

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“…For consumers, meat quality is a very important factor which may include a variety of factors such as meat color, pH, drip loss, cooking loss, shear force, juiciness, and tenderness (Lv et al, 2019). These characteristics are related to sex, age, living environment, and nutrition of poultry (Daszkiewicz & Janiszewski, 2020; Mauri et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of season on slaughter performance, meat quality, muscle amino acid and fatty acid composition, and metabolism of pheasants (Phasianus colchicus)

Liang

Yan

et al. 2022

Animal Science Journal

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This study aimed to investigate the effect of summer and winter on slaughter performance, muscle quality, flavor-related substance content, and gene expression levels related to the fat metabolism of pheasants. One-hundred 1-day-old pheasants were fed for 5 months starting in March and July and then, respectively, slaughtered in summer (August) and winter (December). The results revealed that compared with summer, winter not only increased pheasant live weight, dressed percentage, fulleviscerated yield, and muscle yield (p < 0.05) but also enhanced the activities of SOD and CAT in serum (p < 0.05). Winter significantly increased meat color, the contents of inosinic acid, and flavor amino acid in muscle. Amino acid contents in leg muscles of pheasants in winter were significantly higher than in summer except for histidine (p < 0.05). Winter increased the contents of muscle mono-unsaturated fatty acid, reducing saturated fatty acid. Summer improved fat synthesis in liver, promoted the deposition of triglycerides and cholesterol, and reduced the expression levels of fat metabolism-related genes in muscle, while winter increased the expression levels of genes related to muscle fat metabolism to provide energy for body and affect muscle fatty acid profile. Overall, pheasants fed in winter had better sensory quality and flavor than summer.

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Low-density lipoprotein receptor-related protein 1 regulates muscle fiber development in cooperation with related genes to affect meat quality

Cited by 12 publications

References 46 publications

Comparison of the Structure of Leg and Pectoral Muscles between Lonchura striata and Copsychus saularis

Comparison of the Structure of Leg and Pectoral Muscles between Lonchura striata and Copsychus saularis

Genomic Approaches Reveal Pleiotropic Effects in Crossbred Beef Cattle

Effect of season on slaughter performance, meat quality, muscle amino acid and fatty acid composition, and metabolism of pheasants (Phasianus colchicus)

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