Low-Density Lipoprotein Subfraction as a New Risk Factor for Silent Cerebral Infarction in Hypertensive Patients

Hoshide, Satoshi

doi:10.1291/hypres.29.297

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…[27] Since this study was conducted on young stroke patients, it strongly reflects the relationship between the stroke and lipid subfraction. In addition, Hoshide and Kario[7] reported that lipid subfraction to be a risk factor for silent cerebral infarction. LDL is composed of heterogeneous particles that differ in size, composition, and electrical charge.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that small or oxidized LDL can be one of the most powerful risk factors for developing atherosclerosis and coronary disease. A heritable subclass profile of LDL is associated with increased risk of coronary disease[6] and stroke[7] in humans and is characterized by a predominance of small dense (sd)-LDL particles. Meanwhile, there are a few likely mechanisms underlying the association of lipids and stroke.…”

Section: Introductionmentioning

confidence: 99%

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Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke

Cüre

Tüfekçi

Kırbaş

et al. 2013

Ann Indian Acad Neurol

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Objectives:Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (α), and nitric oxide (NO) have recently emerged as important stroke risk factors. The aim of the study was to investigate the effects of increased levels of small LDL particle size, TNF-α and NO on the developed ischemic stroke and increased carotid artery intima-media thickness (CIMT).Materials and Methods:A total of 29 women and 25 men (a total of 54 ischemic stroke patients) and a similar age group of 50 controls (29 females and 21 males) were included in the study. CIMT, C-reactive protein (CRP), TNF-α, NO, and lipid subfraction test of the two groups were measured.Results:The mean LDL particle size was smaller in patients with stroke than in the controls (26.8 ± 0.31 nm vs. 27.0 ± 0.31 nm, P = 0.003). sd-LDL, TNF-α, NO, CRP, right CIMT, and left CIMT were higher in patients with stroke than in the controls (respectively; 8.2 ± 7.8 mg/dL vs. 3.3 ± 3.5 mg/dL, P < 0.001;75.6 ± 25.0 pg/mL vs. 65.4 ± 9.1 pg/mL, P = 0.009;76.4 ± 53.3 mmol/L vs. 41.5 ± 27.0 mmol/L, P < 0.001;1.9 ± 2.6 mm vs. 0.4 ± 0.3 mm P < 0.001;0.97 ± 0.38 mm vs. 0.83 ± 0.15 mm, P = 0.007;1.04 ± 0.44 mm vs. 0.87 ± 0.19 mm, P = 0.010).Conclusion:These results show that sd-LDL is independently associated with the incidence of stroke and may be a risk factor in the development of stroke. In addition, TNF-α, NO, right CIMT, and left CIMT may be a risk factor in the development of ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke

Cüre

Tüfekçi

Kırbaş

et al. 2013

Ann Indian Acad Neurol

View full text Add to dashboard Cite

show abstract

“…Наиболее выраженная взаимосвязь выявлена для АГ, сниженного содержания в крови липопротеидов высо-кой плотности, повышения концентрации триглице-ридов [9]. Также было отмечено, что риск развития АИ в базальных ганглиях в значительной степени коррели-рует с концентрацией в крови липопротеидов низкой плотности [25]. Индекс массы тела (индекс Кетле) в качестве компонента метаболического синдрома также имеет связь с риском развития АИ [19].…”

Section: распространенность асимптомного инфарктаunclassified

Prevalence and Risk Factors of Asymptomatic Cerebral Infarction

Zhetishev¹,

Камчатнов²,

Михайлова³

et al. 2015

Klinicist

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Low-Density Lipoprotein Subfraction as a New Risk Factor for Silent Cerebral Infarction in Hypertensive Patients

Cited by 2 publications

References 17 publications

Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke

Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke

Prevalence and Risk Factors of Asymptomatic Cerebral Infarction

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