The method of Fractional Borel Summation is suggested in conjunction with self-similar factor approximants. The method used for extrapolating asymptotic expansions at small variables to large variables, including the variables tending to infinity, is described. The method is based on the combination of optimized perturbation theory, self-similar approximation theory, and Borel-type transformations. General Borel Fractional transformation of the original series is employed. The transformed series is resummed in order to adhere to the asymptotic power laws. The starting point is the formulation of dynamics in the approximations space by employing the notion of self-similarity. The flow in the approximation space is controlled, and “deep” control is incorporated into the definitions of the self-similar approximants. The class of self-similar approximations, satisfying, by design, the power law behavior, such as the use of self-similar factor approximants, is chosen for the reasons of transparency, explicitness, and convenience. A detailed comparison of different methods is performed on a rather large set of examples, employing self-similar factor approximants, self-similar iterated root approximants, as well as the approximation technique of self-similarly modified Padé–Borel approximations.