Low diffusion level within a fibroadenoma as the sole sign of ductal carcinoma in situ: A case report

Tagliati, Corrado; Lanni, Giuseppe; Cerimele, Federico; Martino, Antonietta Di; Calamita, Valentina; Pressanti, Gabriella Lucidi; Ying, Mingliang; Giuseppetti, Gian Marco; Argalia, Giulio; Giovagnoni, Andrea

doi:10.3233/bd-201080

Cited by 1 publication

(2 citation statements)

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“…Only five patients (31.3%) in the present study were categorized as BI-RADS 4 on ultrasonography. Additionally, malignant transformation indicators in mammography, such as microcalcifications and distortion of surrounding tissue, were only observed in three cases (18.8%) ( 21 ). As the carcinoma component may be hidden by other components in fibroadenoma, and thus, may not be detected by imaging examinations ( 16 ), it is difficult to differentiate benign fibroadenomas from their counterparts with malignant transformation within them.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, tumor biopsy or excision should potentially be suggested to make a diagnosis in this situation. Notably, a recent study evaluated the role of dynamic contrast-enhanced MRI in diagnosing cancerous lesions developing within fibroadenomas ( 21 ) and revealed that relatively low diffusion of the apparent diffusion coefficient value suggested a malignant transformation within a fibroadenoma. Novel potential imaging methods with high accuracy and efficiency are clinically warranted.…”

Section: Discussionmentioning

confidence: 99%

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Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature

Xu,

Luo,

Mao

et al. 2023

Oncol Lett

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Breast carcinoma arising from a fibroadenoma is an uncommon entity and is frequently detected incidentally during pathological examination or excisional biopsy of a benign breast tumor. Due to only sporadic cases being reported, evidence-based guidelines are not well-established to date. The present report describes 16 patients diagnosed with breast carcinoma arising within a fibroadenoma in the Third Hospital of Nanchang (Nanchang, China) between January 2019 and December 2021 and discusses the clinicopathological characteristics, imaging findings and treatment. The age of patients at diagnosis ranged between 19 and 58 years and a well-defined asymptomatic mass was the most common clinical presentation. Carcinoma occurring in fibroadenoma generally mimics a benign tumor and potential carcinomatous changes may not be detected. Pathologically, carcinoma in situ was the predominant subtype in the present study. Additionally, ductal carcinoma in situ was more common compared with lobular carcinoma in situ in the present case series. Regarding the molecular phenotypes, the majority of cases were categorized as luminal subtype, although other subtypes such as triple-negative and HER2 positive breast cancer were also identified. In the present study, seven patients were treated with breast-conserving surgery and nine patients were treated with mastectomy. Sentinel lymph node biopsy was performed in all patients and none exhibited axillary node metastasis. Additionally, six patients underwent radiotherapy and two received chemotherapy. During the follow-up, all patients were alive and no evidence of disease relapse was observed. In summary, clinicians should be aware of the possibility of carcinoma within a fibroadenoma, which could alter the therapeutical course. Adequate biopsy or excision should be performed in patients with indicators of malignant transformation in a presumed benign breast tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%