Low-dimensional compounds containing bioactive ligands. Part IX: Synthesis, structures, spectra, in vitro antimicrobial and anti-tumor activities and DNA binding of Pd(II) complexes with 7-bromo-quinolin-8-ol

Potočňák, Ivan; Drweesh, Elsayed A.; Farkasová, Veronika; Lüköová, Andrea; Sabolová, Danica; Radojević, Ivana D.; Arsenijević, Aleksandar; Djordjevic, Dragana; Volarević, Vladislav

doi:10.1016/j.poly.2017.07.008

Cited by 11 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the value of the HSA binding constant, the studied complex is able to bind to the tryptophan binding site of HSA (Trp-214), as evidenced by a decrease in its fluorescence intensity. The K SV value of 3.13 � 10 6 M À 1 is similar to values found for other complexes with HXQ ligands (Potoc ˇn ˇa ´k et al, 2017;Harmos ˇova ´et al, 2023) and falls into the optimal range of 10 2 -10 8 M À 1 , which allows effective transport of the complex through the blood Table 5 Cg� � �Cg distance and angles (A ˚, � ) characterizing �-� interactions in 1.…”

Section: Ct Dna and Hsa Binding Propertiessupporting

confidence: 76%

Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid

et al. 2023

Self Cite

View full text Add to dashboard Cite

A new zirconium(IV) complex, diaquabis(8-hydroxyquinoline-2-carboxylato-κ3 N,O 2,O 8)zirconium(IV) dimethylformamide disolvate, [Zr(C10H5NO3)2(H2O)2]·2C3H7NO or [Zr(QCa)2(H2O)2]·2DMF (1) (HQCaH is 8-hydroxyquinoline-2-carboxylic acid and DMF is dimethylformamide), was prepared and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray structure analysis. Complex 1 is a mononuclear complex in which the ZrIV atoms sit on the twofold axis and they are octacoordinated by two N and six O atoms of two tridentate anionic QCa2− ligands, and two aqua ligands. Outside the coordination sphere are two DMF molecules bound to the complex unit by hydrogen bonds. The structure and stability of complex 1 in dimethyl sulfoxide were verified by NMR spectroscopy. The cytotoxic properties of 1 and HQCaH were studied in vitro against eight cancer cell lines, and their selectivity was tested on the BJ-5ta noncancerous cell line. Both the complex and HQCaH exhibited low activity, with IC50 > 200 µM. DNA and human serum albumin (HSA) binding studies showed that 1 binds to calf thymus (CT) DNA via intercalation and is able to bind to the tryptophan binding site of HSA (Trp-214).

show abstract

Section: Ct Dna and Hsa Binding Propertiessupporting

confidence: 76%

Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous research of antimicrobial activity led to different conclusions with most of the studies evidencing markedly lower antifungal activity, 7,26 although a study conducted in 2012 determined that palladium(II) complexes with a derivative of thiosalicylic acid as ligand showed significantly higher antifungal activity towards species from the Aspergillus genus (A. fumigatus, A. flavus and A. restrictus) than the positive control, fluconazole. 6 Garoufis et al explored the antifungal and antibacterial activity of Pd(II) complexes with various ligands (sulphur and nitrogen donor ligands, Schiff bases and ligands used as drugs), and found that they had promising antibacterial but weak antifungal activity.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms

Raković

Radojević

Mladenović

et al. 2018

JSCS

View full text Add to dashboard Cite

The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl] + (C1), [Pd(en)Cl 2 ] (C2), [Pd(DMEAIm iPr)Cl 2 ] (C3) and [Pd(dach)Cl 2 ] (C4) (terpy = 2,2′:6′,2′′-terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAIm iPr = N 2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2ylidene)-N 1 ,N 1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl] + and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC < 0.49 μg mL-1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The interaction of the metal complexes C1-C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV-Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability.

show abstract

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry

Yadav

Shah

2021

Bioorganic Chemistry

163

View full text Add to dashboard Cite

Low-dimensional compounds containing bioactive ligands. Part IX: Synthesis, structures, spectra, in vitro antimicrobial and anti-tumor activities and DNA binding of Pd(II) complexes with 7-bromo-quinolin-8-ol

Cited by 11 publications

References 38 publications

Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid

Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid

Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry

Contact Info

Product

Resources

About