Low-Dose (10-Gy) Total Skin Electron Beam Therapy for Cutaneous T-Cell Lymphoma: An Open Clinical Study and Pooled Data Analysis

Kamstrup, Maria R.; Gniadecki, Robert; Iversen, Lars; Skov, Lone; Petersen, Peter Meidahl; Loft, Annika; Specht, Lena

doi:10.1016/j.ijrobp.2015.01.047

Cited by 77 publications

(68 citation statements)

References 22 publications

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“…The application of TSEBT warrants special expertise and infrastructure which may be mostly available in well-equipped large-scale hospitals. Reported results indicate that TSEBT is an efficacious and tolerable management modality for MF [19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Review Articlementioning

confidence: 99%

“…There are encouraging results with lower doses of TSEBT, however, prospective randomized studies are needed to further refine dose-fractionation schedules with direct comparison of different regimens [6,[19][20][21][22][23]27].…”

Section: Review Articlementioning

confidence: 99%

“…MF is considered to be highly radiosensitive, and encouraging treatment results have been achieved with even low doses of radiation [19][20][21][22][23].…”

Section: Radiotherapy Dose-fractionation Schemes For Mf Managementmentioning

confidence: 99%

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Radiotherapy for Mycosis Fungoides: Review of the Literature

Sager¹,

Gamsiz²,

Dincoglan³

et al. 2017

J Dermatol Res Ther

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Section: Review Articlementioning

confidence: 99%

Section: Review Articlementioning

confidence: 99%

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Radiotherapy for Mycosis Fungoides: Review of the Literature

Sager¹,

Gamsiz²,

Dincoglan³

et al. 2017

J Dermatol Res Ther

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“…Because relapses occurred following low-dose RT, the radiation doses used have been gradually increased up to 36 Gy to obtain a longer-term clinical benefit; however, this more intensive regimen has been associated with significant treatment-related skin toxicities and late relapses [8,28]. Low-dose TSEBT regimens, alone or in combination with other treatments, have been gaining interest recently with the hope of minimizing the risk of adverse events (AEs) and the possibility for repetition in the event of relapse [8,9,[29][30][31]. Pre-or post-TSEBT local RT for tumorous lesions, enlarged lymph nodes, and underdosed sites has been recommended to minimize the risk of local relapse [13].…”

Section: Current Therapeutic Options For Pctclmentioning

confidence: 99%

Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma

Elsayad

Susek

Eich³

2017

Oncol Res Treat

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Total-skin electron beam therapy (TSEBT) is one of most effective treatments that has been used for cutaneous T-cell lymphoma. Low-dose TSEBT regimens (10-12 Gy) appear to be an effective alternative to conventional-dose TSEBT (30-36 Gy), yielding short-term remission of cutaneous manifestations with minimal toxicity. TSEBT can be administered to patients any time after a diagnosis of mycosis fungoides (MF). Patients requiring rapid relief from cutaneous lesions or symptoms may particularly benefit from TSEBT as an initial therapy. Radiotherapy (RT) dose, boost radiation delivery, maintenance treatment, and radiation tolerability may enhance remission rates and improve relapse-free survival following TSEBT. In addition, salvage local RT or TSEBT may be safely applied with high effectiveness. In this review, we focus on the use of TSEBT in patients with several forms of primary cutaneous T-cell lymphoma, and highlight the potential of low-dose TSEBT as part of a promising therapeutic approach.

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“…The CR rates (27%-57%) are lower than those achieved with high-dose therapy, but the duration of response (6-15 months) is similar to TSEB with doses of 30 Gy or greater. 56,57 Despite the lower CR rate associated with low-dose TSEB, this approach is justifiable because repeat courses are well tolerated and can provide excellent palliation. TSEB therapy may be followed by maintenance PUVA, topical nitrogen mustard, and other options such as bexarotene or IFN-a.…”

mentioning

confidence: 99%

How I treat mycosis fungoides and Sézary syndrome

Prince

Whittaker

Hoppe

2016

Blood

149

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Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma variant and is closely related to a rare leukemic variant, Sézary syndrome (SS). MF patients at risk of disease progression can now be identified and an international consortium has been established to address the prognostic relevance of specific biologic factors and define a prognostic index. There are a lack of randomized clinical trial data in MF/SS and evidence is based on a traditional “stage-based” approach; treatment of early-stage disease (IA-IIA) involves skin directed therapies which include topical corticosteroids, phototherapy (psoralen with UVA or UVB), topical chemotherapy, topical bexarotene, and radiotherapy including total skin electron beam therapy. Systemic approaches are used for refractory early-stage and advanced-stage disease (IIB-IV) and include bexarotene, interferon α, extracorporeal photopheresis, histone deacetylase inhibitors, and antibody therapies such as alemtuzumab, systemic chemotherapy, and allogeneic transplantation. However, despite the number of biologic agents available, the treatment of advanced-stage disease still represents an unmet medical need with short duration of responses. Encouragingly, randomized phase 3 trials are assessing novel agents, including brentuximab vedotin and the anti-CCR4 antibody, mogamulizumab. A broader understanding of the biology of MF/SS will hopefully identify more effective targeted therapies.

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Low-Dose (10-Gy) Total Skin Electron Beam Therapy for Cutaneous T-Cell Lymphoma: An Open Clinical Study and Pooled Data Analysis

Cited by 77 publications

References 22 publications

Radiotherapy for Mycosis Fungoides: Review of the Literature

Radiotherapy for Mycosis Fungoides: Review of the Literature

Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma

How I treat mycosis fungoides and Sézary syndrome

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