Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma

Wang, Chunlei; Chen, Xiaofeng; Wu, Jianing; Liu, Huailei; Ji, Zhiyong; Shi, Huaizhang; Gao, Cheng; Han, Dayong; Wang, Ligang; Liu, Yaohua; Yang, Guangchao; Fu, Changyu; Li, Huadong; Zhang, Dongzhi; Liu, Ziyi; Li, Xianfeng; Yin, Fei

doi:10.1016/j.jphotobiol.2013.06.001

Cited by 13 publications

(4 citation statements)

References 32 publications

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“…Furthermore, PS uptake is highly dependent on the cell metabolic state. For example, in vitro studies have demonstrated an enhanced PpIX accumulation in the tumor tissues and a complementary increase in the efficacy of PDT following the upregulation or presence of ATP-binding cascade (ABC) transporters inhibitors [222], iron chelators [223], calcitriol [224], arsenic trioxide [225], or NF-kappaB inhibitors [226]. Despite this high relevance to malignant glioma states, further investigation, as is currently being conducted in third-generation PS testing, to improve tumor specificity through alternative avenues, such as protein markers, is warranted.…”

Section: Limitations Of Pdt and Its Synergistic Agentsmentioning

confidence: 99%

Systematic Review of Photodynamic Therapy in Gliomas

Hsia

Small

Yekula

et al. 2023

Cancers

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Over the last 20 years, gliomas have made up over 89% of malignant CNS tumor cases in the American population (NIH SEER). Within this, glioblastoma is the most common subtype, comprising 57% of all glioma cases. Being highly aggressive, this deadly disease is known for its high genetic and phenotypic heterogeneity, rendering a complicated disease course. The current standard of care consists of maximally safe tumor resection concurrent with chemoradiotherapy. However, despite advances in technology and therapeutic modalities, rates of disease recurrence are still high and survivability remains low. Given the delicate nature of the tumor location, remaining margins following resection often initiate disease recurrence. Photodynamic therapy (PDT) is a therapeutic modality that, following the administration of a non-toxic photosensitizer, induces tumor-specific anti-cancer effects after localized, wavelength-specific illumination. Its effect against malignant glioma has been studied extensively over the last 30 years, in pre-clinical and clinical trials. Here, we provide a comprehensive review of the three generations of photosensitizers alongside their mechanisms of action, limitations, and future directions.

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Section: Limitations Of Pdt and Its Synergistic Agentsmentioning

confidence: 99%

Systematic Review of Photodynamic Therapy in Gliomas

Hsia

Small

Yekula

et al. 2023

Cancers

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“…It was also observed that the mRNA expression of the CPOX enzyme in Porphyrin synthesis was increased after pretreatment with 0.1 µM ATO. Thus, 5-ALA-PDT pretreatment with ATO can prove to be an effective strategy to improve 5-ALA-induced FGR and PDT in glioma [58].…”

Section: Gliomamentioning

confidence: 99%

Reactive Oxygen Species Produced by 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Cancer

Pignatelli,

Umme,

D’Antonio

et al. 2023

IJMS

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Cancer is the leading cause of death worldwide and several anticancer therapies take advantage of the ability of reactive oxygen species to kill cancer cells. Added to this is the ancient hypothesis that light alone can be used to kill cancer cells. 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) is a therapeutic option for a variety of cutaneous and internal malignancies. PDT uses a photosensitizer that, activated by light in the presence of molecule oxygen, forms ROS, which are responsible for the apoptotic activity of the malignant tissues. 5-ALA is usually used as an endogenous pro-photosensitizer because it is converted to Protoporphyrin IX (PpIX), which enters into the process of heme synthesis and contextually becomes a photosensitizer, radiating a red fluorescent light. In cancer cells, the lack of the ferrochelatase enzyme leads to an accumulation of PpIX and consequently to an increased production of ROS. PDT has the benefit of being administered before or after chemotherapy, radiation, or surgery, without impairing the efficacy of these treatment techniques. Furthermore, sensitivity to PDT is unaffected by the negative effects of chemotherapy or radiation. This review focuses on the studies done so far on 5-ALA-PDT and its efficacy in the treatment of various cancer pathologies.

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“…This results in various biological effects ( 264 , 282 , 283 ). (B) The most common types of cell death induced by PDT include apoptosis ( 284 ), autophagy ( 285 ), necrosis ( 286 ), necroptosis ( 287 ), and ferroptosis ( 270 ). (C) ROS produced by PDT can also cause vascular occlusion, leading to vascular damage, thereby affecting the blood supply of tumour cells ( 288 ).…”

Section: Ros-based Glioma Therapymentioning

confidence: 99%

ROS regulation in gliomas: implications for treatment strategies

Yang,

Zhu,

Sun

et al. 2023

Front. Immunol.

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Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia, the blood-brain barrier (BBB), reactive oxygen species (ROS) and tumour neovascularization. Therefore, the traditional treatment effect is limited. As cellular oxidative metabolites, ROS not only promote the occurrence and development of gliomas but also affect immune cells in the immune microenvironment. In contrast, either too high or too low ROS levels are detrimental to the survival of glioma cells, which indicates the threshold of ROS. Therefore, an in-depth understanding of the mechanisms of ROS production and scavenging, the threshold of ROS, and the role of ROS in the glioma TME can provide new methods and strategies for glioma treatment. Current methods to increase ROS include photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT), etc., and methods to eliminate ROS include the ingestion of antioxidants. Increasing/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment.

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Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma

Cited by 13 publications

References 32 publications

Systematic Review of Photodynamic Therapy in Gliomas

Systematic Review of Photodynamic Therapy in Gliomas

Reactive Oxygen Species Produced by 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Cancer

ROS regulation in gliomas: implications for treatment strategies

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