Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion

Lazzarin, Natalia; Vaquero, E.; Exacoustòs, C.; Bertonotti, E.; Romanini, M. E.; Arduini, Domenico

doi:10.1016/j.fertnstert.2008.05.045

Cited by 51 publications

(33 citation statements)

References 28 publications

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“…In conclusion our results can be considered as a sign for a significant endometrial contribution as derivation of blood flow impedance to unexplained group. Mid-luteal or peri-implantation period Doppler measurements should be considered in infertility patients and if impedance to uterine vasculature is found to be high these patients may become candidates for therapies increasing the luteal blood low like aspirin and omega 3 in unexplained infertility and IVF patients (16,17). Embryo freezing and subsequent hormonal preparation of endometrium can be considered.…”

Section: Discussionmentioning

confidence: 99%

Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Uysal¹,

Özbay²,

Ekinci³

et al. 2012

J Turkish German Gynecol Assoc

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Objective: Uterine perfusion, particularly the endometrial blood flow, may have an important role in endometrial receptivity. In order to assess the contribution of sub endometrial blood flow in the etiopathogenesis of unexplained infertility mid luteal-peri-implantation period spiral artery transvaginal color Doppler parameters were measured and compared with fertile controls. Material and Methods: Forty-two consecutive patients admitted toIzmir Katip Celebi University Ataturk Training and Research Hospital, Department of Obstetric and Gynecology with the diagnosis of unexplained infertility after standard diagnostic work up constituted the study group and they were compared with a fertile control group admitted to hospital with non specific gynecological complaints or for check-up in the same period. Mid luteal transvaginal color Doppler ultrasonography was applied to each patient by the same radiologist who was blind to the diagnosis of the particular patient and, RI (resistance index) and PI (pulsatility index) values were calculated.Results: There were no significant differences between the two groups, in respect to age, body mass index, basal hormonal and mid luteal progesterone levels (p>0.05). For the fertile control group, mid luteal-peri-implantation phase endometrial spiral artery mean RI values were calculated as 0.48±0.08 SD and mean PI values as 0.65±0.18 SD. For the study group, mean RI values were calculated as 0.54±0.07 SD, PI values were calculated as 0.80±0.16 SD. The differences for RI (p=0.009) and PI (p=0.004) were statistically significant. Conclusion:According to Doppler parameters, unexplained infertility patients have high impedance blood flow in spiral arteries which means that peri-implantation blood flow in these patient is lower than fertile controls. These findings suggest that endometrial perfusion may have an important contribution to etiopathogenesis of unexplained infertility. (J Turkish-German Gynecol Assoc 2012; 13: 169-71) Key words: Unexplained infertility, endometrial blood flow, endometrial receptivity, transvaginal ultrasonograhy, colored Doppler Received: 13 June, 2012 Accepted: 21 July, 2012 Amaç: Endometrial kan akımının, endometrial implantasyonda önemli rol oynadığı düşünülmektedir. Biz çalışmamızda subendometrial kan akımının açıklanamayan infertilitedeki önemini belirleyebilmek için mid-luteal-periimplantasyon dönemindeki kan akımını TVUSG doppler ile ölçerek fertil kontrol grubu ile karşılaş-tırdık. Gereç ve Yöntemler: Çalışmamıza İzmir Katip Çelebi ÜniversitesiAtatürk Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği'ne infertilite nedeni ile başvurmuş ve yapılan tetkikler sonucunda açıklanamayan infertilite olarak tanı almış 42 hasta ile fertilite dışındaki jinekolojik şikayetler ile başvurmuş fertil hastaların midluteal dönemindeki endometrial kan akımı değerlendirildi. Ölçüm-ler; rezistans indeksi ve pulsatilite indeksi, hastaların hangi gruba ait olduğunu bilmeyen tek radyolog tarafından yapıldı. Abstract ÖzetOriginal Investigation ...

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Section: Discussionmentioning

confidence: 99%

Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Uysal¹,

Özbay²,

Ekinci³

et al. 2012

J Turkish German Gynecol Assoc

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“…[128] Aspirin helps in improving uterine perfusion. [129] Aspirin is useful in many undiagnosed implantation failure patients. However, in the absence of strong evidence, routine use of Aspirin is not recommended (Evidence level II)…”

Section: Methodsmentioning

confidence: 99%

Evidence-based management of recurrent miscarriages

2014

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Recurrent miscarriages are postimplantation failures in natural conception; they are also termed as habitual abortions or recurrent pregnancy losses. Recurrent pregnancy loss is disheartening to the couple and to the treating clinician. There has been a wide range of research from aetiology to management of recurrent pregnancy loss. It is one of the most debated topic among clinicians and academics. The ideal management is unanswered. This review is aimed to produce an evidence-based guidance on clinical management of recurrent miscarriage. The review is structured to be clinically relevant. We have searched electronic databases (PubMed and Embase) using different key words. We have combined the searches and arranged them with the hierarchy of evidences. We have critically appraised the evidence to produce a concise answer for clinical practice. We have graded the evidence from level I to V on which these recommendations are based.

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“…Habara et al 8 found that the resistance to uterine artery blood flow during the midluteal phase was higher in patients with recurrent pregnancy loss. Previous studies provided evidence that low‐dose aspirin as a common anticoagulant can produce a vasodilatory effect 9 . Supplementation with low‐dose aspirin has been widely reported to be effective in improving uterine blood flow and pregnancy outcomes in patients with impaired uterine vascularization who had undergone assisted reproductive technologies 10 .…”

mentioning

confidence: 99%

“…Previous studies provided evidence that low-dose aspirin as a common anticoagulant can produce a vasodilatory effect. 9 Supplementation with low-dose aspirin has been widely reported to be effective in improving uterine blood flow and pregnancy outcomes in patients with impaired uterine vascularization who had undergone assisted reproductive technologies. 10 Based on these observations, an attempt was made to evaluate differences in uterine artery blood flow parameters and pregnancy outcomes, if any.…”

mentioning

confidence: 99%

Effect of Low‐Dose Aspirin on Midluteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss

Kang

Wang

et al. 2016

J of Ultrasound Medicine

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Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion

Cited by 51 publications

References 28 publications

Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis?

Evidence-based management of recurrent miscarriages

Effect of Low‐Dose Aspirin on Midluteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss

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