Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study

Hormonal induction of endometrial receptivity

“…Subsequently Weckstein et al (56) studied 28 recipients of oocyte donation who failed to achieve endometrial thickness of 8 mm during a mock cycle and randomized them to receive low-dose aspirin or no aspirin during the subsequent oocyte donation cycle. Whereas there was no increase in the endometrial thickness during the subsequent donation cycle, the aspirin group had a statistically significant increase in implantation rates.…”

Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs

“…Meanwhile, the risk of ovarian hyperstimulation increased after extensive ovarian stimulation, and the best time of oocyte retrieval was sometimes missed [12]. Alternative treatments including low dose aspirin [13] and vaginal sildenafil (Viagra) [14,15] have also been proposed in improving endometrial development and pregnancy outcome. However, both of them focused on the improvement on uterine artery blood flow rather than on endometrial thickness.…”

Assessment and treatment of repeated implantation failure (RIF)

“…Treatment with high dose oral estrogen or vaginal estradiol application, intended to increase the estradiol level in the serum, as well as in the vicinity of the endometrium, has demonstrated only marginal success [22,107]. Similarly, treatment with low dose aspirin [114] or vaginal sildenafil [90], which presumably increases blood flow to the uterus, consequently improving the response to estradiol, were rather disappointing [86]. Our approach is to freeze embryos when a thin endometrium is noticed, and to transfer them in a natural cycle, if possible; or alternatively, in an artificial cycle, while applying increased dosages of estradiol, for as long as three weeks before progesterone is added.…”