Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study

Haapsamo, Mervi; Martikainen, Hannu; Tinkanen, Helena; Heinonen, Seppo; Nuojua-Huttunen, Sinikka; Räsänen, Juha

doi:10.1093/humrep/deq286

Cited by 37 publications

(39 citation statements)

References 29 publications

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“…This is in agreement with previous reports and suggests that the mechanism behind the increased incidence of PE in IVF pregnancies is unlikely to be related to impaired uteroplacental perfusion. The absence of any prophylactic effect of low‐dose aspirin on the incidence of PE in IVF pregnancies, different from what occurs in natural pregnancies, further corroborates this hypothesis.…”

Section: Discussionsupporting

confidence: 56%

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Rizzo

Aiello

Pietrolucci

et al. 2016

Ultrasound in Obstet & Gyne

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Section: Discussionsupporting

confidence: 56%

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Rizzo

Aiello

Pietrolucci

et al. 2016

Ultrasound in Obstet & Gyne

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“…16 As an illustration of this debate, a recent study failed to find any association in a cohort of women followed after in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI). 17 Recently, however, a meta-analysis that collected data from 11 748 women was able to show that the administration of aspirin at low doses before the 16th week of gestation resulted in a relative risk of pre-eclampsia of 0.44. 18 In contrast, the improvement is completely absent when the treatment is given after the 16th week.…”

Section: Introductionmentioning

confidence: 99%

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Bakhti

Vaiman

2011

Hypertens Res

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The aim of this study was to evaluate whether low doses of aspirin (100 mg per day) administered to a homogeneous population of women early (8-10 weeks) during their first pregnancy improved the outcome of gestation hypertensive disorders. This study was performed at the Blida Hospital, where many early deliveries and pregnancy complications are observed. A total of 164 women were either treated (82) or used as controls (82). Treatment increased the gestation length by 12 days on average, thus triggering an approximate 150-g increase in newborn weight. This consistently improved the outcome for all patients with respect to all parameters investigated. Overall, the relative risk of developing hypertensive disorders of gestation was reduced to 0.07 (confidence interval¼0.01-0.51). In our series, we did not observe deleterious consequences for the fetus (teratogenicity and fetotoxicity) or adverse outcomes for the mothers. Despite the limited number of patients analyzed, the present study is one of the largest investigating early aspirin treatment of gestational hypertensive diseases. In addition, the time of aspirin administration is among the earliest yet examined. The data tend to confirm the results obtained from other cohorts on the overall benefit of aspirin treatment for gestational disorders. In the future, molecular or ultrasonographic markers of these diseases could help to screen patients before applying the treatment.

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“…We identified 780 potentially relevant studies from the following databases: 569 from EMBASE and 211 from MEDLINE. We excluded 750 studies after title and abstract screening using the predefined inclusion and exclusion criteria; the remaining 30 studies were retrieved in full for detailed evaluation [3,11,13,14,24–49]. Agreement between reviewers for study selection was optimal ( K = 0.91).…”

Section: Resultsmentioning

confidence: 99%

Low‐dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta‐analysis of the literature

Dentali

Ageno

Rezoagli

et al. 2012

Journal of Thrombosis and Haemostasis

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vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-analysis of the literature. J Thromb Haemost 2012; 10: 2075- 85.Summary. Background: It was hypothesized that low-dose aspirin could improve implantation rates in subsequent pregnancies in women undergoing in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI). Previous studies have shown inconclusive results or focused on surrogate endpoints. We therefore conducted a systematic review and meta-analysis of the literature investigating the effect of low-dose aspirin on hard outcomes, including live birth rate, pregnancy rate and miscarriage. Methods: MEDLINE and EMBASE databases were searched up to November 2011. Randomized controlled trials comparing low-dose aspirin with placebo/no treatment in IVF/ICSI women were included. Pooled odds ratios (ORs) and 95%confidence intervals (CIs) were calculated. Results: Seventeen studies with 6403 patients were included. The use of aspirin did not improve live birth pregnancy rate compared with placebo or no treatment (1.08; 95% CI, 0.90, 1.29). Pregnancy rates were significantly increased in patients randomized to lowdose aspirin (OR, 1.19; 95% CI, 1.01, 1.39), but miscarriage rates were not (OR, 1.18; 95% CI, 0.82, 1.68). Results of sensitivity analyses including high-quality studies did not show statistically significant differences in all considered endpoints. Conclusions: The results of this study do not show a substantial efficacy of aspirin inwomen undergoing IVF/ICSI and do not support the use of low-dose aspirin to improve the success of IVF/ICSI in terms of pregnancy outcomes. Further high-quality studies evaluating the possible efficacy of aspirin in selected groups of patients are warranted.

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Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study

Cited by 37 publications

References 29 publications

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Low‐dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta‐analysis of the literature

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