2007
DOI: 10.1111/j.1745-7254.2007.00613.x
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Low-dose carvedilol reduces transmural heterogeneity of ventricular repolarization in congestive heart failure

Abstract: Aim: To study the effects of carvedilol on the transmural heterogeneity of ventricular repolarization in rabbits with congestive heart failure (CHF). Methods: Rabbits were randomly divided into 3 groups: control, CHF and carvedilol treated CHF group. Monophasic action potential duration (MAPD) in the 3 myocardial layers was simultaneously recorded. Results: All the rabbits in the CHF group had signs of severe CHF. Compared with the control group, the mean blood pressure and cardiac output were significantly de… Show more

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