Low-dose combined exposure of carboxylated black carbon and heavy metal lead induced potentiation of oxidative stress, DNA damage, inflammation, and apoptosis in BEAS-2B cells

Jiang, Nan; Wen, Haiyan; Zhou, Meifang; Lei, Tiantian; Shen, Jianyun; Zhang, Di; Wang, Rong; Wu, Hai; Jiang, Shuanglin; Li, Wenyong

doi:10.1016/j.ecoenv.2020.111388

Cited by 43 publications

(17 citation statements)

References 44 publications

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“…Another mechanism that can contribute to an enhanced toxicity in case of combined exposure to different pollutants is that one of them can make the cells more sensitive to the second one. This is what observed Jiang et al suggesting that the intracellular perturbations caused by black carbon made the cells susceptible to lead toxicity (Jiang et al, 2020). Li et al described that by accumulating in cells, zinc oxide nanoparticles altered cell membranes and enhanced the toxicity of co-exposed copper nanoparticles (Li et al, 2015).…”

Section: Sensitizing Effectsupporting

confidence: 60%

“…This is perfectly exemplified by the study from Jiang et al who assessed the combined toxicity of carboxylated black carbon and lead acetate on human bronchial epithelial cells at the no-observed-adverse-effect level (NOAEL). They demonstrated that co-exposure to these compounds could induce some unexpected toxicity, even beyond their known individual toxicities (Jiang et al, 2020).…”

Section: Poly-exposure Issuementioning

confidence: 99%

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Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Forest

2021

NanoImpact

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Air pollution is considered as a major public health issue worldwide. It consists of a complex mixture of pollutants including nanoparticles to which we are increasingly exposed to due to the dramatic development of the nanotechnologies and their incidental or intentional release in the environment. Consequently, some concerns have raised about the combined toxicity of air particulates and other air pollutants on human health. However, the interactions between the contaminants and their resulting combined toxicity are often overlooked. Indeed, the biological effects triggered by nanoparticles are usually assessed focusing on individual nanoparticles, while their interaction with co-contaminants can deeply impact, either positively or negatively, their biodistribution, fate in the organism and toxicological profile (additive, synergistic or antagonistic responses). This paper presents a bibliographic review on the combined toxicity of nanoparticles and co-pollutants and discusses the underlying mechanisms. It also highlights the scarcity of data in the current literature, arguing for an urgent need to take into account the mixture effects to be more representative of real-life conditions for a better and accurate human health risk assessment and management.

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Section: Sensitizing Effectsupporting

confidence: 60%

Section: Poly-exposure Issuementioning

confidence: 99%

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Forest

2021

NanoImpact

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“…Since mitochondria are considered to not only be a major source of ROS, but also the target of cellular ROS (Erikstein et al, 2010;Jiang et al, 2020), changes in MMP of RAW264.7 cells was examined by use of JC-1 staining. TDCIPP caused the collapse of MMP.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis using isobaric tags for relative and absolute quantification technology reveals mechanisms of toxic effects of tris (1,3‐dichloro‐2‐propyl) phosphate on RAW264.7 macrophage cells

Zhang

Wang

Giesy

et al. 2021

J of Applied Toxicology

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Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the most commonly used organophosphorus flame retardants. Immuno-toxicity induced by TDCIPP is becoming of increasing concern. However, effects of TDCIPP on immune cells and mechanisms resulting in those effects are poorly understood. In this study, it was determined, for the first time, by use of isobaric tags for relative and absolute quantification (iTRAQ) based proteomic techniques expression of global proteins in RAW264.7 cells exposed to 10 μM TDCIPP. A total of 180 significantly differentially expressed proteins (DEPs) were identified. Of these, 127 were up-regulated and 53 were down-regulated. The DEPs associated with toxic effects of TDCIPP were then screened by use of Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes for enrichment analysis. Results showed that these DEPs were involved in a number of pathways including apoptosis, DNA damage, cell cycle arrest, immunetoxicity, and signaling pathways, such as the Toll-like receptor, PPAR and p53 signaling pathways. The complex regulatory relationships between different DEPs, which might play an important role in cell death were also observed in the form of a protein-protein interaction network. Meanwhile, mitochondrial membrane potential (MMP) in RAW264.7 cells after TDCIPP treatment was also analyzed, the collapse of the MMP was speculated to play an important role in TDCIPP induced apoptosis.Moreover, some of the important regulator proteins discovered in this study, such as Chk1, Aurora A, would provide novel insight into the molecular mechanisms involved in toxic responses to TDCIPP.

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“…Even if the toxicities of individual compounds are well characterized, unexpected adverse effects can be induced by the mixing of such compounds [127,128]. Even worse, compounds that do not elicit adverse effects individually can induce significant toxicity when in a mixture, resulting in an underestimation of the risk [129]. While additive or synergistic effects can occur (effects higher than the simple addition of the effects of the individual components) [130], antagonistic effects can also be reported [124,127,131,132].…”

Section: Combined Effects Of Nanoparticlesmentioning

confidence: 99%

Experimental and Computational Nanotoxicology—Complementary Approaches for Nanomaterial Hazard Assessment

Forest

2022

Nanomaterials

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The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized. Such potential toxicity must be carefully assessed with the underlying mechanisms elucidated. To that purpose, different approaches can be used. First, experimental toxicology consisting of conducting in vitro or in vivo experiments (including clinical studies) can be used to evaluate the nanomaterial hazard. It can rely on variable models (more or less complex), allowing the investigation of different biological endpoints. The respective advantages and limitations of in vitro and in vivo models are discussed as well as some issues associated with experimental nanotoxicology. Perspectives of future developments in the field are also proposed. Second, computational nanotoxicology, i.e., in silico approaches, can be used to predict nanomaterial toxicity. In this context, we describe the general principles, advantages, and limitations especially of quantitative structure–activity relationship (QSAR) models and grouping/read-across approaches. The aim of this review is to provide an overview of these different approaches based on examples and highlight their complementarity.

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Low-dose combined exposure of carboxylated black carbon and heavy metal lead induced potentiation of oxidative stress, DNA damage, inflammation, and apoptosis in BEAS-2B cells

Cited by 43 publications

References 44 publications

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Proteomic analysis using isobaric tags for relative and absolute quantification technology reveals mechanisms of toxic effects of tris (1,3‐dichloro‐2‐propyl) phosphate on RAW264.7 macrophage cells

Experimental and Computational Nanotoxicology—Complementary Approaches for Nanomaterial Hazard Assessment

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