PurposeTo evaluate the influence of heart rate on coronary calcium scores (CCS) using a dynamic phantom on four high-end computed tomography (CT) systems from different manufacturers.
MethodsArtificial coronary arteries were moved in an anthropomorphic chest phantom at linear velocities, corresponding to <60, 60-75 and >75 beats per minute (bpm). Data was acquired with routinely used clinical protocols for CCS on four highend CT systems (CT1-CT4). CCS, quantified as Agatston and mass scores were compared to reference scores at <60 bpm. Influence of heart rate was assessed for each system with the cardiac motion susceptibility (CMS) index.
ResultsAt increased heart rates (>75 bpm), Agatston scores of the low mass calcification were similar to the reference score, while Agatston scores of the medium and high mass calcification increased significantly up to 50% for all CT systems. Threefold CMS increases at >75 bpm in comparison with <60 bpm were shown. For medium and high mass calcifications, significant differences in CMS between CT systems were found.
ConclusionHeart rate substantially influences CCS for high-end CT systems of four major manufacturers, but CT systems differ in motion susceptibility. Follow-up CCS CT scans should be acquired on the same CT system and protocol, and preferably with comparable heart rates. CT1 Low 99 (95-136) -7 (-31; 2) 0.144 -21 (-31; 6) 0.078 Medium 351 (344-375) 4 (-4; 30) 0.176 32 (11; 33) 0.043* High 515 (450-553) -3 (-11; 41) 0.686 50 (41; 58) 0.043* CT2 Low 105 (79-120) -6 (-21; 30) 0.893 -9 (-38; 11) 0.279 Medium 315 (267-347) 11 (1; 39) 0.043* 33 (7; 67) 0.043* High 421 (387-459) 14 (2; 48) 0.043* 49 (19; 70) 0.043* CT3 Low 103 (89-117) -10 (-20; 28) 0.686 6 (-18; 23) 0.893 Medium 304 (295-340) 4 (-2; 9) 0.225 9 (3; 19) 0.043* High 424 (406-443) 4 (0; 12) 0.043* 22 (9; 28) 0.042* CT4 Low 108 (105-132) -5 (-17; 15) 0.345 -10 (-21; 1) 0.080 Medium 367 (320-377) 33 (23; 34) 0.042* 26 (14; 45) 0.043* High 505 (472-544) 38 (36; 53) 0.043* 45 (44; 54) 0.043*For example, at increased heart rate, CT3 showed an increase in Agatston score of 22% for the high mass calcification, while differences of 45% to 50% were found for the other CT systems.