2021
DOI: 10.15587/2519-4852.2021.249375
|View full text |Cite
|
Sign up to set email alerts
|

Low-dose digoxin enhances the anticonvulsive potential of carbamazepine and lamotrigine in chemo-induced seizures with different neurochemical mechanisms

Abstract: "Non-antiepileptic" drugs have a strong potential as adjuvants in multidrug-resistant epilepsy treatment. In previous study the influence of low doses of digoxin, which do not affect the myocardium, on the anticonvulsant potential of classical commonly used anti-epileptic drugs under conditions of seizures, induced by pentylenetetrazole and maximal electroshock, has been investigated. The aim of the study was to investigate the influence of digoxin at a sub-cardiotonic dose on the anticonvulsant potentia… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 15 publications
0
1
0
Order By: Relevance
“…The use of non-antiepileptic medicines as adjuvant agents, which have anticonvulsant properties and enhance the effects of classical AEDs, is gaining more comprehensive application. Such medicines include, in particular, non-steroidal anti-inflammatory medicines, sodium channel blockers (in particular, lidocaine), slow calcium channel blockers, β-blockers, the If-channel blocker ivabradine, the competitive xanthine oxidase inhibitor allopurinol, statins, selective phosphodiesterase-5 inhibitors (sildenafil, tadalafil), the cardiac glycoside digoxin [5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…The use of non-antiepileptic medicines as adjuvant agents, which have anticonvulsant properties and enhance the effects of classical AEDs, is gaining more comprehensive application. Such medicines include, in particular, non-steroidal anti-inflammatory medicines, sodium channel blockers (in particular, lidocaine), slow calcium channel blockers, β-blockers, the If-channel blocker ivabradine, the competitive xanthine oxidase inhibitor allopurinol, statins, selective phosphodiesterase-5 inhibitors (sildenafil, tadalafil), the cardiac glycoside digoxin [5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%