Low-Dose Ethanol Has Impacts on Plasma Levels of Metabolites Relating to Chronic Disease Risk in SAMP8 mice

Fu, Churan; Yang, Yongshou; Kumrungsee, Thanutchaporn; Kimoto, Akiko; Izu, Hanae; Katô, Norihisa

doi:10.3177/jnsv.66.553

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…To date, several mass spectrometry-based metabolomic studies of blood or cerebrospinal fluid (CSF) sample models have been published for the SAMP8 model, often following the effects of various factors (food supplements, drugs, treatment, etc.) on the development or improvement of AD metabolomics [55][56][57][58]. NMR-based characterization of the SAMP8 model was performed by Jiang et al [59] on serum samples of 12-month-old SAMP8 and SAMR1 mice.…”

Section: Discussionmentioning

confidence: 99%

Age-related metabolic and neurodegenerative changes in SAMP8 mice

Pačesová

Holubová

Hrubá

et al. 2022

Aging

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The most important risk factor for the development of sporadic Alzheimer's disease (AD) is ageing. Senescence accelerated mouse prone 8 (SAMP8) is a model of sporadic AD, with senescence accelerated resistant mouse (SAMR1) as a control. In this study, we aimed to determine the onset of senescence-induced neurodegeneration and the related potential therapeutic window using behavioral experiments, immunohistochemistry and western blotting in SAMP8 and SAMR1 mice at 3, 6 and 9 months of age. The Y-maze revealed significantly impaired working spatial memory of SAMP8 mice from the 6 th month. With ageing, increasing plasma concentrations of proinflammatory cytokines in SAMP8 mice were detected as well as significantly increased astrocytosis in the cortex and microgliosis in the brainstem. Moreover, from the 3 rd month, SAMP8 mice displayed a decreased number of neurons and neurogenesis in the hippocampus. From the 6 th month, increased pathological phosphorylation of tau protein at Thr231 and Ser214 was observed in the hippocampi of SAMP8 mice. In conclusion, changes specific for neurodegenerative processes were observed between the 3 rd and 6 th month of age in SAMP8 mice; thus, potential neuroprotective interventions could be applied between these ages.

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Section: Discussionmentioning

confidence: 99%

Age-related metabolic and neurodegenerative changes in SAMP8 mice

Pačesová

Holubová

Hrubá

et al. 2022

Aging

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Effects of Regular Low-Level Alcohol Consumption in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

2022

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The effects of alcohol consumption on health are suggested to depend on the amount of alcohol consumed. We investigated the objective and subjective health effects of the daily consumption of a small amount of alcohol in healthy individuals using a randomized, double-blind, placebo-controlled crossover study. Accordingly, 15 male and 27 female Japanese adults with average or lower general well-being schedule (GWBS) scores were asked to consume a beverage with 0.5% (v/v) alcohol (~4 g of alcohol a day; test beverage) and a placebo beverage two times daily for 4 weeks each. Regular low-level alcohol consumption significantly decreased the serum liver function indexes (aspartic aminotransferase, alanine aminotransferase, and lactate dehydrogenase) before and after consumption (p = 0.034, 0.033, and 0.013, respectively). The small amount of alcohol did not affect the participants’ GWBS scores; however, a stratified analysis with poor subjective well-being revealed that these changes differed significantly between low-level alcohol consumption and placebo-treated subjects (16.0 vs. 11.5, p = 0.041). In addition, changes in serum testosterone levels demonstrated a higher trend in the group that received the test beverage compared with the group that received the placebo beverage (p = 0.051). Daily low-level alcohol consumption may have positive effects on liver function and subjective well-being.

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Low-Dose Ethanol Has Impacts on Plasma Levels of Metabolites Relating to Chronic Disease Risk in SAMP8 mice

Cited by 2 publications

References 42 publications

Age-related metabolic and neurodegenerative changes in SAMP8 mice

Age-related metabolic and neurodegenerative changes in SAMP8 mice

Effects of Regular Low-Level Alcohol Consumption in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

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