Low-Dose Excimer 308-nm Laser for Treatment of Lichen Planopilaris

Navarini, Alexander A.

doi:10.1001/archdermatol.2011.335

Cited by 41 publications

(23 citation statements)

References 4 publications

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“…General situation and treatment results of OLP patients efficacy of 308-nm excimer laser in the treatment of lichen planus was satisfactory(Kollner, Wimmershoff, Landthaler, & Hohenleutner, 2003;Krueger et al, 1995;Mehraban & Feily, 2014;Navarini, Kolios, Prinz-Vavricka, Haug, & Tr€ ueb, 2011). In the present study, six OLP patients were treated with 308-nm excimer laser, achieving relatively satisfactory results.…”

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confidence: 50%

“…Results revealed that, epidermal T lymphocytes in skin lesions were removed at 48 hr after the initial treatment, suggesting that 308-nm excimer laser has direct effect on infiltrated T lymphocytes in skin lesions (Bianchi et al, 2003). Considerable literatures have reported that, the efficacy of 308-nm excimer laser in the treatment of lichen planus was satisfactory (Kollner, Wimmershoff, Landthaler, & Hohenleutner, 2003;Krueger et al, 1995;Mehraban & Feily, 2014;Navarini, Kolios, Prinz-Vavricka, Haug, & Tr€ ueb, 2011). In the present study, six OLP patients were treated with 308-nm excimer laser, achieving relatively satisfactory results.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of oral lichen planus using 308-nm excimer laser

Liu

Sun

Yang

et al. 2017

Dermatologic Therapy

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Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereby cannot be used in the treatment of OLP. Lymphocytic infiltration is evident in the lesions of lichen planus, and the direct irradiation of 308-nm excimer laser can induce apoptosis of the T lymphocytes in skin lesions, thereby has a unique therapeutic effect on the diseases involving T lymphocytes. This study aims to investigate the efficacy of 308-nm excimer laser in the treatment of OLP. A total of six OLP patients were enrolled into this study, and further pathological diagnosis was conducted, then 308-nm excimer laser was used in the treatment. The efficacy of 308-nm excimer laser in the treatment of OLP was satisfactory. The clinical symptoms of five patients were significantly improved. In two patients, the erosion surface based on congestion and the surrounding white spots completely disappeared, and clinical recovery was achieved. Three patients achieved partial remission, that is, the erosion surface healed, congestion and white spot area shrunk by more than 1/2 of the primary skin lesions. In the remaining one patient, the erosion surface had not completely healed after treatment, and congestion and white spot area shrunk by less than 1/2 of the primary skin lesions. Only one patients had developed mild pain during the treatment, and this symptom alleviated by itself. The 308-nm excimer laser therapy can serve as a safe and effective treatment for OLP.

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confidence: 50%

Section: Discussionmentioning

confidence: 99%

Treatment of oral lichen planus using 308-nm excimer laser

Liu

Sun

Yang

et al. 2017

Dermatologic Therapy

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“…In addition to these treatments, which were shown to be effective in clinics, there are other options that probably could be employed to treat patients with FFA. Ultraviolet B phototherapy or excimer laser, which are possible inhibitors of inflammatory responses, are potentially effective therapeutic options for patients with FFA and LPP (Navarini et al, 2011). Ultraviolet B irradiation could induce IL-10 in human keratinocytes as well as the promotion of FoxP3 transcription, while decreased levels of several cytokines are involved in the differentiation of Th1 and Th17 cells, including IL-12, IL-17, IL-20, IL-22, IL-23, and TNF-α (Zhang et al, 2016, Coimbra et al, 2010).…”

Section: Potential Therapeutic Optionsmentioning

confidence: 99%

Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment

Tavakolpour

Mahmoudi

Abedini

et al. 2019

International Journal of Women's Dermatology

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Frontal fibrosing alopecia (FFA) is a relatively new scarring alopecia that is considered a variant of lichen planopilaris (LPP) with no recognized promising treatments. In this study, we tried to clarify the underlying signaling pathways and their roles in the pathogenesis and progression of FFA. Because of several differences in clinical manifestations, response to treatments, and pathological findings, these two conditions could be differentiated from each other. Taking into account the already discussed signaling pathways and involved players such as T cells, mast cells, and sebaceous glands, different possible therapeutic options could be suggested. In addition to treatments supported by clinical evidence, such as 5 alpha-reductase inhibitors, topical calcineurin inhibitors, hydroxychloroquine, peroxisome proliferator-activated receptor gamma agonists, and oral retinoid agents, various other treatment strategies and drugs, such as phototherapy, Janus kinase inhibitors, dehydroepiandrosterone, sirolimus, cetirizine, and rituximab, could be suggested to mitigate disease progression. Of course, such lines of treatment need further evaluation in clinical trials.

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“…[42,43] Navarini et al successfully utilized excimer laser (treatments twice per week -cumulative mean dose of 4300 mj/cm 2 ) to treat 13 patients with lichen planopilaris and achieved a significant reduction in clinical signs of inflammation. [44] The successful treatment of LPP patients with excimer laser therapy along with anecdotal clinical success in FFA patients suggests a potential role for excimer laser therapy use in the initial phase of FFA to dampen the inflammatory effects of the disease. In our clinical experience excimer laser is very useful in reducing inflammation and peripilar casts in patients with active disease.…”

Section: Excimer Lasermentioning

confidence: 99%

Therapeutic options in frontal fibrosing alopecia

Fertig

Aleid

Tosti

2016

Expert Opinion on Orphan Drugs

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Introduction: The prevalence of frontal fibrosing alopecia (FFA) is increasing worldwide and early diagnosis and prompt treatment are necessary to prevent definitive scarring. Currently, there are no FDA approved treatments for FFA. This paper seeks to explore the efficacy of current therapeutic options in FFA. Areas covered: The evidence available to date gives some guidance as to potential effective treatment approaches for FFA patients which include 5-alpha-reductase inhibitors, intralesional steroids, hydroxychloroquine, topical calcineurin inhibitors, excimer laser, pioglitazone, oral tetracyclines and minoxidil. A MEDLINE search (PubMed 1994(PubMed -2015 was performed to identify the cases described in the literature. The MEDLINE search terms Frontal Fibrosing Alopecia and Treatment were used in combination with no language restrictions. We included case reports, case series, review articles and clinical trials which specifically mentioned attempted therapeutic modalities in FFA and their respective outcomes following treatment. Expert opinion: I first reported the efficacy of finasteride in FFA patients 12 years ago and still widely utilize this medication when treating patients with FFA. In treating FFA patients I prefer to associate oral finasteride to topical tacrolimus, hydroxychloroquine and excimer laser in patients with clinical or dermoscopic evidence of active inflammation.

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Low-Dose Excimer 308-nm Laser for Treatment of Lichen Planopilaris

Cited by 41 publications

References 4 publications

Treatment of oral lichen planus using 308-nm excimer laser

Treatment of oral lichen planus using 308-nm excimer laser

Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment

Therapeutic options in frontal fibrosing alopecia

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