Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population

Liu, Dong-Chen; Yan, Jianjun; Wang, You-Nan; Wang, Ze‐Mu; Xie, Zhiyong; Ma, Yao; Yang, Yang; Yang, Li; Wang, Liansheng

doi:10.18632/oncotarget.12243

Cited by 14 publications

(9 citation statements)

References 60 publications

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“…In a multi-ethnic study involving 6,508 participants, Miller et al found a statistically significant lower incidence of cardiovascular events in ≥ 1 cup/day tea drinkers (adjusted hazard ratio, 0.71; 95% CI, 0.53, 0.95) ( 34 ). A similar inverse association was observed between tea consumption and CVD mortality ( 35 ), risk of coronary heart disease (CHD) ( 36 ), incident MI ( 37 ), and both paroxysmal AF and persistent AF ( 38 ). Several studies have suggested that there was no correlation between tea consumption and the risk of developing CVD or CHD ( 39 , 40 ).…”

Section: Discussionsupporting

confidence: 53%

No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study

Chen

Sun²,

Zheng³

2022

Front. Cardiovasc. Med.

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BackgroundNumerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea consumption and several CVD outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).MethodsIndependent single-nucleotide polymorphisms (SNPs) genome-wide significantly associated with tea consumption were used as instrumental variables (IVs). Summary statistics for CVD outcomes were obtained from the corresponding genetic consortia and the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analytical method, and MR estimates from different data sources were combined using fixed-effects meta-analysis. Supplementary MR analyses, including the weighted median, MR-Egger, and the MR pleiotropy residual sum and outlier methods, were conducted to evaluate the robustness of the results. Further MR analyses were repeated by including more genetic variants at a higher P-value threshold.ResultsWe found that genetically predicted tea consumption was not causally associated with any CVD outcomes in the IVW method using data from large genetic consortia [CAD: odds ratio (OR) = 1.00, 95% confidence interval (CI), 0.91, 1.10, P = 0.997; MI: OR = 0.98, 95% CI, 0.90, 1.08, P = 0.751; AF: OR = 0.97, 95% CI, 0.92, 1.03, P = 0.350; HF: OR = 0.96, 95% CI, 0.88, 1.05, P = 0.401] or the FinnGen consortium (CAD: OR = 1.06, 95% CI, 0.96, 1.17, P = 0.225; MI: OR = 1.01, 95% CI, 0.89, 1.15, P = 0.882; AF: OR = 1.00, 95% CI, 0.88, 1.14, P = 0.994; HF: OR = 0.96, 95% CI, 0.88, 1.04, P = 0.362). The results were robust and consistent across meta-analysis, supplementary MR analyses, and analyses with more IVs included.ConclusionThis MR study revealed no causal association between tea consumption and four CVD outcomes, suggesting that tea consumption may not be beneficial for the primary prevention of CVD.

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Section: Discussionsupporting

confidence: 53%

No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study

Chen

Sun²,

Zheng³

2022

Front. Cardiovasc. Med.

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“…Several observational studies appear to have focused on outcomes related to the mind [32][33][34] or heart [35][36][37][38]. Longitudinal research found that regular tea drinking (green, fermented, floral) amongst older Chinese adults was associated with fewer depressive symptoms [39].…”

Section: Observational Evidencementioning

confidence: 99%

“…Other prospective research using data from the Chinese Kadoorie Biobank found that daily tea consumption (black, oolong or green tea) reduced is chaemic heart disease risk, particularly in rural, healthy weight, non-diabetic adults [36]. Liu DC, et al (2016) again conducted research in a Chinese population and found that low-dose green tea ingestion, which accounted for the frequency, concentration, and duration of green tea intake, lowered a trial fibrillation incidence [37]. In the Greek Ikaria Island Study (a region with one of the highest global life expectancies), tea drinking was associated with a reduced risk of CVD [38].…”

Section: Observational Evidencementioning

confidence: 99%

Tea for Minds and Hearts: A Scoping Review

Derbyshire¹,

TJ²,

Jenkins³

2022

Nutr Food Technol Open Access

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Tea is a ubiquitous and staple beverage for many people globally. It is well documented that mental well being and cardiovascular health are both recognized as being important in determining general health. The two are intricately linked as people with mental health issues are more likely to have heart disease. We systematically searched the PubMed database and selected studies by predefined eligibility criteria. The reviewed studies presented a large body of evidence indicating that black tea drinking could benefit markers of heart health, including vascular and endothelial function. There is emerging evidence that tea drinking (black and green) and aromatic inhalation of certain teas (e.g., Darjeeling and Assam teas) could aid relaxation, lower stress, dementia risk and cognitive decline and potentially improve attention and psychomotor speed in advanced age. Further human trials are warranted.

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“…They showed that low doses of green tea had a significant protective effect on the incidence of paroxysmal and persistent AF. 98 …”

Section: Plants and Their Ingredients With Antiarhythmic Propertiesmentioning

confidence: 99%

A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs

Beik

Joukar

Najafipour

2020

Journal of Traditional and Complementary Medicine

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This paper aimed to compile information on plants or their compounds which have experimentally shown antiarrhythmic effect and to scrutinize the efficacy and potency of them and their potential interaction with conventional cardiac drugs. Literature searches were accomplished by using numerous electronic databases, and the available knowledge on different parts of herbs and their ingredients with antiarrhythmic effects up to 2019 were identified and collected. The results indicate that 36 herbs or their derivatives can be effective in the treatment of arrhythmias, especially in animal and cellular models. They affect various ionic channels in different action potential phases. The alterations in ionic currents lead to changing in the amplitude and duration of the action potential, effective refractory period, maximum velocity, resting membrane potential, channel trafficking, or intracellular calcium concentration. The agents that prolong action potential duration and effective refractory period such as dauricine and sophocarpine seem to be more beneficial if more comprehensive studies confirm their efficacy and safety. It is noteworthy that the consumption of some herbal agents for cardiovascular (e.g. Hawthorn and Ginseng) or other (e.g. Ginseng and Licorice) therapeutic purposes may boost the pro-arrhythmogenic effect of current cardiovascular drugs such as cardiac glycosides. This study accentuates known plants or their derivatives with anti-arrhythmic effects, potential interaction with other cardiac drugs, and the possible mechanisms involved. It can assist clinicians and scientists in research and therapeutic approaches to the management of cardiac arrhythmias.

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Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population

Cited by 14 publications

References 60 publications

No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study

No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study

Tea for Minds and Hearts: A Scoping Review

A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs

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