1981
DOI: 10.3109/17453678108991763
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Low-Dose Heparin in Proximal Femoral Fractures:Failure to Prevent Deep-Vein Thrombosis

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Cited by 11 publications
(4 citation statements)
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“…The high frequency of deep vein thrombosis (43-91%) and pulmonary embolism (2.5%) in unprotected patients undergoing surgery for fractures of the proximal femur [1][2][3] demands an effective prevention. In patients undergoing emergency surgery for a hip fracture, intravenous dextran is an effective prophylactic agent that consistently reduces the frequency of postoperative venous thrombosis [4,5].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The high frequency of deep vein thrombosis (43-91%) and pulmonary embolism (2.5%) in unprotected patients undergoing surgery for fractures of the proximal femur [1][2][3] demands an effective prevention. In patients undergoing emergency surgery for a hip fracture, intravenous dextran is an effective prophylactic agent that consistently reduces the frequency of postoperative venous thrombosis [4,5].…”
Section: Discussionmentioning
confidence: 99%
“…Deep vein thrombosis (DVT) occurs frequently after fracture of the proximal femur. The reported rates of DVT and pulmonary embolism are 43-91% and 2.5% respectively, in the absence of prophylaxis [1][2][3]. A number of studies have shown the effectiveness of low dose heparin and dextran as prophylaxis in patients undergoing elective hip surgery or surgical repair of hip fractures [3][4][5][6][7].…”
mentioning
confidence: 99%
“…In the absence of prophylaxis, patients undergoing elective major joint replacement and those with hip fracture have a DVT risk of approximately 50% as shown in studies performed in the 1970s, 1980s, and 1990s 19,40,41 (Table 6.1). 42–91,67,92…”
Section: Elective Hip Replacementmentioning
confidence: 99%
“…[39,65] In hip fracture surgery, clinical studies have revealed an average 50% reduction in venous thrombosis from an incidence of 50% in untreated pa-tients to approximately 25% in patients receiving unfractionated heparin prophylaxis) 55,62,[66][67][68][69][70][71] No major or fatal haemorrhagic events were encountered in these trials. Heparin is a glycosaminoglycan, and exerts its anticoagulant activity by catalysing the inactivation of thrombin by antithrombin III.…”
Section: 5 Unfractionated Heparinmentioning
confidence: 99%