Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Guo, Zhenhui; Zhang, Jintao; Liu, Xuemei; Unsinger, Jacqueline; Hotchkiss, Richard S.; Cao, Yuqing

doi:10.1016/j.ynpai.2022.100096

Cited by 10 publications

(3 citation statements)

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“…Interestingly, the Treg defect may also be associated with migraine, as patients with migraine have lower serum levels of these cells ( 41 ). The Tregs activity was also responsible for alleviating trigeminal sensitization in a chronic migraine animal model ( 42 ). In that study, low-dose IL-2, a Tregs activator, was used to alleviate trigeminal activation.…”

Section: Discussionmentioning

confidence: 99%

The relationship between migraine and Hashimoto’s thyroiditis: a single center experience

Nowaczewska,

Straburzyński,

Meder

et al. 2024

Front. Neurol.

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IntroductionHashimoto’s thyroiditis (HT) is nowadays the leading cause of hypothyroidism with high and still growing prevalence in general population, but there are lack of data regarding migraine and HT connection.MethodsThe aim of this study was to analyze the prevalence of HT in migraine and to check if the presence of HT influence migraine severity. This retrospective observational cohort study involved consecutive migraine patients consulted at our Headache Center with diagnosis of migraine. Electronic charts of patients were collected, including data on migraine type, presence of cranial autonomic symptoms (CAS), monthly migraine days (MMD), medication overuse headache (MOH), and the presence of comorbidities including HT.ResultsWe found 928 eligible migraine patients, 88.7% were women. The mean age was 36.09 years. 592 (63.8%) were diagnosed with episodic migraine (EM), the rest with chronic migraine (CM). MOH was additionally diagnosed in 258 (27.8%) patients. The duration of migraine was 15.99 years. 106 (11.4%) was diagnosed with HT, 148 (15.9%) with hypothyroidisms, while 84 (9.05%) had both diagnosis. Migraine patients with HT were significantly older (p < 0.001), were more frequently women (p = 0.0017), had longer duration of migraine (p < 0.001), had CAS more frequently (<0.001), developed CM (p = 0.0169) and depression more frequently (p = 0.0047) and had more MMD (p = 0.0195) as compared with individuals without HT. According to our multivariate logistic model, the presence CM was positively associated with HT (OR 1.76, p = 0.045), MOH and duration of migraine, while negatively associated with aura.ConclusionHT is very prevalent in migraine patients. This is the first study considering migraine and HT to be comorbid and suggesting that HT may influence the course of migraine causing its chronification.

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Section: Discussionmentioning

confidence: 99%

The relationship between migraine and Hashimoto’s thyroiditis: a single center experience

Nowaczewska,

Straburzyński,

Meder

et al. 2024

Front. Neurol.

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“…It has also been confirmed [ 32 ] that the interictal level of IL-10 in migraine patients decreases, indicating that IL-10 is closely related to migraine remission. A later study further pointed out that IL-10 signaling pathways in trigeminal ganglions are potential targets for migraine treatment [ 74 ]. Therefore, the IL-10/IL-10R pathway may be a promising way to inhibit migraine pain symptoms by regulating crosstalk between microglia and astrocytes.…”

Section: Anti-inflammatory Pathways Related To Migraines In Astrocyte...mentioning

confidence: 99%

Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

et al. 2023

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Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The astrocytes and microglia in the central nervous system are vital in inducing neurogenic inflammation in migraine. Recently, it has been found that there may be a crosstalk phenomenon between microglia and astrocytes, which plays a crucial part in the pathology and treatment of Alzheimer's disease and other central nervous system diseases closely related to inflammation, thus becoming a novel hotspot in neuroimmune research. However, the role of the crosstalk between microglia and astrocytes in the pathogenesis and treatment of migraine is yet to be discussed. Based on the preliminary literature reports, we have reviewed relevant evidence of the crosstalk between microglia and astrocytes in the pathogenesis of migraine and summarized the crosstalk pathways, thereby hoping to provide novel ideas for future research and treatment.

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“…Moreover, a repeated administration of low-dose interleukin-2 (IL-2) was able to induce an increase in Treg cells and prevent NTG-induced behavioral changes, while this was not possible in Treg-depleted mice [71]. It was subsequently demonstrated that low-dose IL-2 acts through IL-10 and TGF-β signaling [72]. All these considered, the role of T lymphocytes in the pathogenesis of migraine appears to be well supported.…”

Section: Shared Molecular Mechanisms Between Migraine and Sarcoidosismentioning

confidence: 99%

Common Clinical and Molecular Pathways between Migraine and Sarcoidosis

Tana¹,

García‐Azorín

Cinetto

et al. 2023

IJMS

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Migraine and sarcoidosis are two distinct medical conditions that may have some common biological and clinical pathways. Sarcoidosis is a chronic granulomatous disease characterized by the formation of granulomas in various organs, including the lungs, skin, cardiovascular system, lymph nodes, and brain. Migraine is a common comorbidity in sarcoidosis patients and a common neurological disorder characterized by recurrent headaches that can be accompanied by other symptoms, such as nausea, vomiting, and sensitivity to light and sound. There have been several reports of individuals with neurosarcoidosis experiencing migraines, though the exact relationship between the two disorders is not well understood. Both conditions have been associated with inflammation and the activation of the immune system. In sarcoidosis, the formation of granulomas is thought to be an immune response to the presence of an unknown antigen. Similarly, the pain and other symptoms associated with migraines are thought to be caused by inflammation in the brain and the surrounding blood vessels. There is also evidence to suggest an interplay of environmental and genetic factors playing a role in both conditions, but evidence is inconsistent with the hypothesis of shared genetic susceptibility. This review aims to illustrate common clinical and biological pathways between migraine and sarcoidosis, including inflammation and dysregulation of the immune system, with a focus on the cumulative burden of concurrent disorders and therapeutic implications.

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Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Cited by 10 publications

References 50 publications

The relationship between migraine and Hashimoto’s thyroiditis: a single center experience

The relationship between migraine and Hashimoto’s thyroiditis: a single center experience

Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

Common Clinical and Molecular Pathways between Migraine and Sarcoidosis

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