Low-Dose Intramuscular Hepatitis B Vaccination in Medical Students: 4-Year Follow-Up

Erensoy, Selda; Bilgiç, Altınay; Arda, Bilgin; Özer, Özlem

doi:10.1007/s15010-002-2078-1

Infection

2002

DOI: 10.1007/s15010-002-2078-1

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Low-Dose Intramuscular Hepatitis B Vaccination in Medical Students: 4-Year Follow-Up

Selda Erensoy¹,

Altınay Bilgiç²,

Bilgin Arda³

et al.

Abstract: Long-term effective protection against HB could be obtained in medical students with this scheme. Low-dose HB im vaccination can be utilized as a cost-saving vaccination strategy.

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“…The diagnosis predominantly relies on the detection of hepatitis B surface antigen (HBsAg). An antibody titer against HBsAg of at least 10 mIU/mL provides immunity (199). The detection of hepatitis B DNA without HBsAg signifies occult hepatitis B virus infection.…”

mentioning

confidence: 99%

Therapy of other viral infections: herpes to hepatitis

Chakrabarty¹,

Beutner²

2004

Dermatol Ther

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Over the past several years, there has been an increase in knowledge pertaining to the diagnosis and management strategies for the herpes family (Types 1-8), the pox viruses, mumps, measles, rubella, and parvovirus B19 as well as the viral etiologies of hepatitis. Various antiviral treatments, such as nucleoside analogs and interferon therapy, have been available to reduce the signs and symptoms of these common viral infections. This article summarizes the preferred treatment strategies to be employed for each of the viruses for reducing severity, duration, recurrences (notably in the herpes family), transmission rates, as well as preventive alternatives. The majority of the therapeutic options attenuate the course of disease. Treatment decisions are driven by knowledge of the natural history and often are tailored to incorporate clinical circumstances for individual patients. Promotion of community awareness and the development of vaccines should be emphasized in the battle against these common viruses, particularly the herpes simplex viruses, the pox viruses, and hepatitis B.

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mentioning

confidence: 99%

Therapy of other viral infections: herpes to hepatitis

Chakrabarty¹,

Beutner²

2004

Dermatol Ther

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European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus

et al. 2005

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Exposure prevention is the primary strategy to reduce the risk of occupational bloodborne pathogen infections in healthcare workers (HCW). HCWs should be made aware of the medicolegal and clinical relevance of reporting an exposure, and have ready access to expert consultants to receive appropriate counselling, treatment and follow-up. Vaccination against hepatitis B virus (HBV), and demonstration of immunisation before employment are strongly recommended. HCWs with postvaccinal anti-HBs levels, 1-2 months after vaccine completion, >10 mIU/mL are considered as responders. Responders are protected against HBV infection: booster doses of vaccine or periodic antibody concentration testing are not recommended. Alternative strategies to overcome non-response should be adopted. Isolated anti-HBc positive HCWs should be tested for anti-HBc IgM and HBV-DNA: if negative, anti-HBs response to vaccination can distinguish between infection (anti-HBs >50 mUI/ml 30 days after 1st vaccination: anamnestic response) and false positive results(anti-HBs >10 mUI/ml 30 days after 3rd vaccination: primary response); true positive subjects have resistance to re-infection. and do not need vaccination The management of an occupational exposure to HBV differs according to the susceptibility of the exposed HCW and the serostatus of the source. When indicated, post-exposure prophylaxis with HBV vaccine, hepatitis B immunoglobulin or both must be started as soon as possible (within 1-7 days). In the absence of prophylaxis against hepatitis C virus (HCV) infection, follow-up management of HCV exposures depends on whether antiviral treatment during the acute phase is chosen. Test the HCW for HCV-Ab at baseline and after 6 months; up to 12 for HIV-HCV co-infected sources. If treatment is recommended, perform ALT (amino alanine transferase) activity at baseline and monthly for 4 months after exposure, and qualitative HCV-RNA when an increase is detected.

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Is a low dose of hepatitis B vaccine enough for a rapid vaccination scheme

Wang

Boland²,

Guo³

et al. 2003

WJG

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Low-Dose Intramuscular Hepatitis B Vaccination in Medical Students: 4-Year Follow-Up

Abstract: Long-term effective protection against HB could be obtained in medical students with this scheme. Low-dose HB im vaccination can be utilized as a cost-saving vaccination strategy.

Cited by 3 publications

References 11 publications

Therapy of other viral infections: herpes to hepatitis

Therapy of other viral infections: herpes to hepatitis

European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus

Is a low dose of hepatitis B vaccine enough for a rapid vaccination scheme

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