Low-dose ionising radiation and cardiovascular diseases – Strategies for molecular epidemiological studies in Europe

Kreuzer, Michaela; Auvinen, Anssi; Cardis, Elisabeth; Hall, Janet; Jourdain, Jean-René; Laurier, Dominique; Little, Mark P.; Peters, Annette; Raj, Ken; Russell, Nicola S.; Tapio, Soile; Zhang, Wei; Gomolka, Maria

doi:10.1016/j.mrrev.2015.03.002

Cited by 69 publications

(55 citation statements)

References 133 publications

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“…Ionizing radiation has long been known to raise the risks of cancer (Abbott, 2015). In addition to high doses of radiation, low-dose ionizing radiation (LDIR) might increase the risk of cardiovascular disease, lens opacity, and some other noncancerous diseases (Hammer et al, 2013;Kamiya et al, 2015;Kreuzer et al, 2015). The authors of previous research have reported that cardiovascular morbidity and mortality may occur decades after ionizing radiation exposure (Yan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Zhou¹,

Hao²,

Guo³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Long-term radiation exposure affects human health. Ionizing radiation has long been known to raise the risk of cancer. In addition to high doses of radiation, low-dose ionizing radiation might increase the risk of cardiovascular disease, lens opacity, and some other non-cancerous diseases. Low-and high-dose exposures to ionizing radiation elicit different signaling events at the molecular level, and may involve different response mechanisms. The health risks arising from exposure to low doses of ionizing radiation should be re-evaluated. Health workers exposed to ionizing radiation experience low-dose radiation and have an increased risk of hematological malignancies. Reproductive function is sensitive to changes in the physical environment, including ionizing radiation. However, data is scarce regarding the association between occupational radiation exposure and risk to human fertility. Sperm DNA integrity is a functional parameter of male fertility evaluation. Hence, we aimed to report sperm quality and DNA damage in men from Jilin Province, China, who were occupationally exposed to ionizing radiation. Sperm motility and normal morphology were significantly lower in the exposed compared with the non-exposed men. There was no statistically significant difference in sperm concentration between exposed and non-exposed men. The sperm DNA fragmentation index was significantly higher in the exposed than the non-exposed men. Chronic long-term exposure to low doses of ionizing radiation could affect sperm motility, normal morphology, and the sperm DNA fragmentation index in the Chinese population. Sperm quality and DNA integrity are functional parameters that could be used to evaluate occupational exposure to ionizing radiation.

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Section: Introductionmentioning

confidence: 99%

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Zhou¹,

Hao²,

Guo³

et al. 2016

Genet. Mol. Res.

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“…The choice of lung uranium dose in the main analyses was based on the following: (1) primary organ of uranium intake after inhalation of uranium dusts and a site of a potential local inflammation that may lead to a atherosclerosis development10 and (2) high correlation (Pearson’s correlation coefficient >0.8) between uranium organ doses to heart and kidney that may be involved in pathophysiological mechanisms of CSD. Sensitivity analyses were performed using doses for heart and kidney, second dosimetry scenario, a lag time of 5 and 10 years, and restricting analyses to subgroups of CSD (IHD and CeVD).…”

Section: Methodsmentioning

confidence: 99%

“…Radiation may induce CSD through four mechanisms: (1) initiation of atherosclerosis, (2) reduction in capillary density leading to myocardial fibrosis, (3) direct damage to cardiac structures and (4) other indirect mechanisms 10. However, cautious interpretation of the low-dose epidemiological studies is often suggested, since the exact mechanism is still unknown, especially for internal intake of α-emitters that tend to target particular tissues.…”

Section: Introductionmentioning

confidence: 99%

Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

et al. 2017

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“…One way to do this would be to conduct molecular epidemiological studies, by integrating the use of biomarkers in epidemiological studies (Palmer 2007, Zins et al 2010, Kreuzer et al 2015a. Various types of biomarkers could be used in epidemiological studies as a means to improve the risk assessment process, as discussed in (Pernot et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Concerted Uranium Research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure

et al. 2016

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The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure. The aim of the European Commission concerted action CURE (Concerted Uranium Research in Europe) was to develop protocols for such a future collaborative research project, in which dosimetry, epidemiology and biology would be integrated to better characterize the effects of occupational uranium exposure. These protocols were developed from existing European cohorts of workers exposed to uranium together with expertise in epidemiology, biology and dosimetry of CURE partner institutions. The preparatory work of CURE should allow a large scale collaborative project to be launched, in order to better characterize the effects of uranium exposure and more generally of alpha particles and low doses of ionizing radiation.

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Low-dose ionising radiation and cardiovascular diseases – Strategies for molecular epidemiological studies in Europe

Cited by 69 publications

References 133 publications

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

Concerted Uranium Research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure

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