Low dose ketamin

Wiryana, Made; Sinardja, I Ketut; Budiart, I Gede; Gde, Tjokorda; Senapathi, Agung; Widnyana, M.; Aryabiantara, I Wayan; Hartawan, I Gusti Agung Gede Utara; Parami, Pontisomaya; Pradhana, Ni Putu Adinda Putra; Pradhana, Adinda Putra

doi:10.15562/bjoa.v1i1.4

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Серед негативних наслідків його дії, що може суттєво обмежувати використання, слід зокрема відзначити парез кишечника або ileus, що спричиняє закрепи. Також показано, що кетамін впливає на кальцієві сигнальні шляхи в різних типах клітин [7,8]ketamine, on mICAT. Patchclamp and tensiometry techniques were used to investigate the mechanisms of the inhibitory effects of ketamine on mICAT in single mouse ileal myocytes, as well as on intestinal motility.…”

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Inhibitory Action of the General Anesthetic Ketamine on Intracellular Calcium Transients and Smooth Muscle Contractions of the Mouse Small Intestine

Melnyk¹,

Dryn²,

Dziuba³

et al. 2023

Fiziol Zh

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The mechanisms of the negative consequences of general anaesthetics action on the nervous system have been studied in detail, but regarding smooth muscle function, such issues have not yet been sufficiently addressed. In this study, we investigated the effect of the general intravenous anaesthetic ketamine on the level of intracellular calcium in isolated ileum myocytes and the contractile activity of smooth muscle strips of the mouse small intestine. The concentration of intracellular calcium in cells was measured using the Ca2+-sensitive fluorescent dye Fura-2, and tensiometry was used to record the contractile activity of smooth muscles. It was shown that ketamine at a concentration of 100 µM significantly, by 40%, suppressed carbachol-induced contractile reactions of the ileum. The inhibitory effect correlated with the suppression of the intracellular calcium responses to carbachol in isolated smooth muscle cells after the addition of ketamine to the extracellular solution, which was by 65% on average. These results contribute to our better understanding of the possible membrane and intracellular mechanisms of the development of post-surgical intestinal motility disorders.

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Section: вступunclassified

Inhibitory Action of the General Anesthetic Ketamine on Intracellular Calcium Transients and Smooth Muscle Contractions of the Mouse Small Intestine

Melnyk¹,

Dryn²,

Dziuba³

et al. 2023

Fiziol Zh

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Influence of ketamine, propofol or isoflurane on intraocular pressure, heart rate and blood pressure in healthy dogs premedicated with medetomidine and midazolam

Khaleghi,

Sarchahi,

Kazemi Mehrjerdi

et al. 2023

Veterinary Medicine & Sci

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BackgroundAccording to the findings of several studies, sedatives and anaesthetics have different effects on the functioning of the cardiovascular system and intraocular pressure (IOP). For accurate diagnosis, treatment and surgery with minimal complications, it is necessary to be aware of the effects of sedatives and anaesthetics on the cardiovascular system and IOP.ObjectivesThe aim of this study was to evaluate the effects of sedatives (medetomidine and midazolam) and anaesthetics (ketamine, propofol and isoflurane) on IOP, heart rate (HR) and blood pressure in dogs.MethodsIn this study, 10 dogs participated in three treatments using a randomised cross‐over design, with a 1‐week washout period between each treatment. Dogs in all treatments were premedicated with medetomidine and midazolam. Anaesthesia was induced using ketamine, propofol, or isoflurane and maintained for 60 min with the appropriate doses of each drug. The cardiovascular variables (heart rate, and systolic, diastolic and mean arterial pressures) and IOP were measured at different timepoints: before premedication (baseline values, T‐Bas), 15 min after medetomidine administration (T‐Med), 20 min after midazolam administration (T‐Mid) and at 15 (T‐15), 30 (T‐30), 45 (T‐45) and 60 (T‐60) min after anaesthesia induction.ResultsMedetomidine significantly reduced the IOP and HR and did not significantly change the mean arterial pressure (MAP). Midazolam significantly reduced the IOP while did not significantly change the HR and MAP. Ketamine and isoflurane significantly increased the IOP and HR while did not significantly change the MAP. Propofol significantly increased the HR, but did not cause significant changes in IOP and MAP.ConclusionsConsidering that anaesthetics are typically administered in conjunction with pre‐anaesthetic drugs, the increases in IOP induced by ketamine and isoflurane are not important, as the IOP did not exceed the baseline values. However, further studies are required to investigate these effects in patients with elevated IOP.

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Suppression of the Small Intestine Shrinkable Activity After Usage of the Anesthetic Ketamine

Dziuba¹,

Мельник²,

Дринь³

et al. 2020

Pain Anaesth Int Care

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Low dose ketamin

Cited by 4 publications

References 10 publications

Inhibitory Action of the General Anesthetic Ketamine on Intracellular Calcium Transients and Smooth Muscle Contractions of the Mouse Small Intestine

Inhibitory Action of the General Anesthetic Ketamine on Intracellular Calcium Transients and Smooth Muscle Contractions of the Mouse Small Intestine

Influence of ketamine, propofol or isoflurane on intraocular pressure, heart rate and blood pressure in healthy dogs premedicated with medetomidine and midazolam

Suppression of the Small Intestine Shrinkable Activity After Usage of the Anesthetic Ketamine

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