Low-dose Magnesium Sulfate Therapy in Severe Preeclampsia and Eclampsia: A Safe and Effective Regime

Kuraishy, Amina; Ali, Manazir; Akhtar, Nishat; Akhtar, Saeed

doi:10.5005/jp-journals-10028-1620

Cited by 1 publication

(2 citation statements)

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“…Magnesium sulfate should be continued up until 24 h following the delivery, and it is intended to help in the prevention, as well as the management, of seizures during the stabilization time [92]. Tendon reflex, respiration, and urinary output ought to be mandatorily monitored [93]. Calcium supplementation of 1 g daily starting from the 12th gestational week is recommendable for patients at risk for preeclampsia and in cases of low-calcium diets [94].…”

Section: Therapy and Pregnancymentioning

confidence: 99%

“…Intravenous loading dose of 4-6 g over 20-30 min followed by maintenance dose of 1-2 g hourly [56] Intended to help in prevention, as well as the management, of seizures during stabilization time [92] Infusion should continue for 24 h after delivery. Deep tendon reflexes are lost at magnesium serum levels of 9 mg/dl, respiratory distress occurs at 12 mg/dl and cardiac arrest at 30 mg/dl [93] Calcium supplementation 1 g daily starting from the 12th gestational week [94] Reduces preeclampsia risk for patients at high risk and in cases of low-calcium leve l diets [94] /…”

Section: Therapy and Pregnancymentioning

confidence: 99%

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Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy

Lackovic,

Nikolic,

Jankovic

et al. 2023

Medicina

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Stroke during pregnancy and preeclampsia are two distinct but interrelated medical conditions, sharing a common denominator—blood control failure. Along with cardiovascular diseases, diabetes, dyslipidemia, and hypercoagulability, hypertension is undoubtedly a major risk factor associated with stroke. Even though men have higher age-specific stroke rates, women are facing higher life-long stroke risk, primarily due to longer life expectancy. Sex hormones, especially estrogen and testosterone, seem to play a key link in the chain of blood pressure control differences between the genders. Women affected with stroke are more susceptible to experience some atypical stroke manifestations, which might eventually lead to delayed diagnosis establishment, and result in higher morbidity and mortality rates in the population of women. Preeclampsia is a part of hypertensive disorder of pregnancy spectrum, and it is common knowledge that women with a positive history of preeclampsia are at increased stroke risk during their lifetime. Preeclampsia and stroke display similar pathophysiological patterns, including hypertension, endothelial dysfunction, dyslipidemia, hypercoagulability, and cerebral vasomotor reactivity abnormalities. High-risk pregnancies carrying the burden of hypertensive disorder of pregnancy have up to a six-fold higher chance of suffering from stroke. Resemblance shared between placental and cerebral vascular changes, adaptations, and sophisticated auto-regulatory mechanisms are not merely coincidental, but they reflect distinctive and complex cardiovascular performances occurring in the maternal circulatory system during pregnancy. Placental and cerebral malperfusion appears to be in the midline of both of these conditions; placental malperfusion eventually leads to preeclampsia, and cerebral to stoke. Suboptimal performances of the cardiovascular system are proposed as a primary cause of uteroplacental malperfusion. Placental dysfunction is therefore designated as a secondary condition, initiated by the primary disturbances of the cardiovascular system, rather than an immunological disorder associated with abnormal trophoblast invasion. In most cases, with properly and timely applied measures of prevention, stroke is predictable, and preeclampsia is a controllable condition. Understanding the differences between preeclampsia and stroke in pregnancy is vital for healthcare providers to enhance their clinical decision-making strategies, improve patient care, and promote positive maternal and pregnancy outcomes. Management approaches for preeclampsia and stroke require a multidisciplinary approach involving obstetricians, neurologists, and other healthcare professionals.

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Section: Therapy and Pregnancymentioning

confidence: 99%