Low Dose of Green Synthesized Silver Nanoparticles is Sufficient to Cause Strong Cytotoxicity via its Cytotoxic Efficiency and Modulatory Effects on the Expression of PIK3CA and KRAS Oncogenes, in Lung and Cervical Cancer Cells

Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

“…Green silver nanoparticles (AgNPs) elucidated a lower rise in a number of hematological indicators of treated fish when compared with chemically prepared AgNPs [ 18 ]. At relatively modest doses (6.25–25 μl), the Ferula asafetida AgNPs were fatal to lung and cervical carcinoma cell lines and down-regulated the expression of PIK3CA and KRAS oncogenes, indicating their efficacy, safety and tolerability [ 19 ]. When evaluated at low doses (10 mg/Kg), gold nanoparticles (AuNPs) isolated from Egyptian propolis extract exhibited notable antibacterial, anticancer, and anti-mycobacterial effects while evidencing minor toxicities and organ damage within albino rats [ 20 ].…”