Low dose oral anticoagulation therapy in Chinese children with congenital heart disease

Abstract

A low dose warfarin regimen to maintain a target INR of 1.5-2.5 provides adequate protection in Chinese children against thromboembolism whilst allowing safe outpatient monitoring of the anticoagulation status.

Congenital heart disease: Current indications for antithrombotic therapy in pediatric patients

“…This finding has been reported in several other recent studies as well [2][3][4]. Similarly, children between the ages of 1 and 6 years of age were also found to need an increased dosage of warfarin compared to older children between 6 and 18 years of age.…”

Management of Stroke in Infants and Children

“…However, studies of low-dose anticoagulation in children with various conditions have yielded inconclusive results, and studies on CVST have not been done. 478,479 Recommendations for the Use of Warfarin in Children With Stroke…”

Long-Term Changes in Coronary Artery Aneurysms in Patients With Kawasaki Disease-Comparison of Therapeutic Regimens-

“…34 The daily warfarin dose of 0.1 mg/kg was almost same as that for children younger than 10 years of age in a study 35 that adopted a target INR of 1.5-2.5. Although the thrombotest is now being replaced by INR, it is valuable with respect to detecting an abnormality in the coagulation factor completely dependent on vitamin K. A thrombotest level of 27% is equivalent to INR of 1.5, 36 and the present study adopted a daily warfarin dose of 0.1 mg/kg, adjusted with the thrombotest approximately 30%.…”