Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx

Egan, Conleth A.; Rallis, Tena M.; Meadows, Kappa P.; Krueger, Gerald G.

doi:10.1016/s0190-9622(99)70446-9

Cited by 85 publications

(35 citation statements)

References 8 publications

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“…Egan[81] reported use of low-dose oral methotrexate in five patients with recalcitrant palmoplantar pompholyx. The patients did not respond to conventional therapy and showed significant improvement or clearing after addition of methotrexate to their treatment.…”

Section: Pathogenesismentioning

confidence: 99%

Hand eczema

et al. 2014

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Hand eczema is often a chronic, multifactorial disease. It is usually related to occupational or routine household activities. Exact etiology of the disease is difficult to determine. It may become severe enough and disabling to many of patients in course of time. An estimated 2-10% of population is likely to develop hand eczema at some point of time during life. It appears to be the most common occupational skin disease, comprising 9-35% of all occupational diseases and up to 80% or more of all occupational contact dermatitis. So, it becomes important to find the exact etiology and classification of the disease and to use the appropriate preventive and treatment measures. Despite its importance in the dermatological practice, very few Indian studies have been done till date to investigate the epidemiological trends, etiology, and treatment options for hand eczema. In this review, we tried to find the etiology, epidemiology, and available treatment modalities for chronic hand eczema patients.

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Section: Pathogenesismentioning

confidence: 99%

Hand eczema

et al. 2014

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“…It has been reported in case series of patients with unresponsive hand dermatitis [89] and other types of recalcitrant eczema [90]. Good results were achieved with a range of initiation doses between 5 and 20 mg weekly after 1-2 months of therapy.…”

Section: Systemic Corticosteroids and Immunosuppressive Agentsmentioning

confidence: 94%

Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

2015

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Hand dermatitis is a socially significant health problem. This review provides a discussion on the clinical features and patterns as well as the differential diagnosis of hand dermatitis, because these are essential for proper diagnosis in clinical practice. The morphology, however, is poorly related to the etiology in chronic cases. In all cases of chronic hand dermatitis, a full diagnostic examination should be undertaken and the etiology should be clarified and addressed in the treatment concept, instead of just moving directly from a morphological diagnosis to therapy. Preventive measures should be included in the treatment concept according to etiology. A stepwise approach for escalating therapy is advised, including basic topical therapy, topical corticosteroids, calcineurin inhibitors, as well as phototherapy and systemic therapy with corticosteroids, alitretinoin, cyclosporine, methotrexate, azathioprine, and others.

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“…114 Several case series and retrospective studies have demonstrated the efficacy and safety of treatment with low-dose methotrexate for moderate-to-severe AD in adults who were unresponsive to topical treatments, antihistamines and at least one of the second-line treatments. [114][115][116][117][118] Egan and colleagues 119 reported successful treatment with methotrexate of five patients with severe pompholyx. One open-label prospective study evaluated 12 patients with AD, eight of whom achieved sustained clinical improvement.…”

Section: American Academy Of Dermatology Guidelinesmentioning

confidence: 99%

The use of methotrexate in dermatology: a review

et al. 2011

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Methotrexate is a synthetic folic acid analogue valued for both its anti-proliferative and anti-inflammatory properties. Considered one of the original immune-modifying agents, it is used widely for the treatment of steroid-recalcitrant inflammatory diseases. While there are abundant studies documenting its efficacy in rheumatic diseases, the use of methotrexate for dermatological conditions, with the exception of psoriasis, has yet to be comprehensively explored. This two-part review firstly outlines current data concerning the pharmacology of methotrexate, including its mechanism of action, side-effect profile and recommended therapeutic approach, and, secondly, examines the emerging evidence for methotrexate's efficacy in a wide range of cutaneous disorders.

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Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx

Cited by 85 publications

References 8 publications

Hand eczema

Hand eczema

Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

The use of methotrexate in dermatology: a review

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