Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study

Rutkowski, T.; Jaroszewicz, Jerzy; Piotrowski, Damian; Ślosarek, Krzysztof; Sobala-Szczygieł, Barbara; Słonina, Dorota; Włostowska, Bożena; Bodusz, Dawid; Piasecki, Maciej; Nachlik, Michał; Oczko-Grzesik, Barbara; Gadek, A; Kowal, Dorota; Rutkowski, Roman; Wojarska-Tręda, Elżbieta; Składowski, Krzysztof

doi:10.3390/biomedicines11030858

Biomedicines

2023

DOI: 10.3390/biomedicines11030858

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Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study

T. Rutkowski

Jerzy Jaroszewicz

Damian Piotrowski

et al.

Abstract: Purpose: Results of the low-dose radiation therapy (LDRT) in patients with pneumonia due to COVID-19 has been presented. Methods: Fifteen patients received a single-fraction radiation dose of 1 Gy to the bilateral lungs due to pre-ARDS pneumonia in the course of COVID-19. Follow-up was performed on days 1, 3, 5, 7, 14 after LDRT. Results: Eleven patients (73%) were released up until day 28. Median hospitalization was 20 days; 28-day mortality was 13%. Median O2 saturation improved within 24 h after LDRT in 14/… Show more

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Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study

Dinakar,

Jakka,

Vemannagari

et al. 2023

The British Journal of Radiology

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Objective Evaluate role of low dose radiotherapy (LDRT) in COVID-19 pneumonia. Methods Sixty-five patients 40 years or older tested positive for COVID-19 reverse transcriptase-polymerase chain reaction with mild to moderate acute respiratory distress syndrome (ARDS), were randomised 1:1, from fourth June 2021, to either best standard of care (control arm) according to the Indian Council of Medical Research guidelines or a single dose of Low Dose Radiotherapy (LDRT-0.5Gy) to both lungs along with best standard of care (experimental arm). The primary outcome was either progression to severe disease (PaO2/FiO2 ratio <100 mmHg) within 28 days of randomisation or all-cause mortality at 28 days. If the primary outcome could have been prevented, it was considered “favourable”; if not, it was considered “unfavourable.” Results Thirty-three patients were allocated to experimental arm, thirty-two to control arm. An intention to treat analysis was performed. Unfavourable outcome was seen in 5 (15.2%) patients in experimental arm, vs , 12 (37.5%) patients in control arm, odds of an unfavourable outcome in experimental arm were 0.3, 95% CI 0.09 to 0.97; 2-sided p = 0.04. Four and five patients died in experimental and control arm, respectively. No radiation-induced toxicity was observed. Conclusion LDRT reduced the number of patients with unfavourable outcome at 28 days. Advances in knowledge One of the few randomized studies showing reduced unfavourable outcome in mild to moderate ARDS COVID-19 patients receiving LDRT. CTRI/2021/06/034001, Clinical Trials Registry - India (ICMR-NIMS)

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Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study

Dinakar,

Jakka,

Vemannagari

et al. 2023

The British Journal of Radiology

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Is Low-Dose Lung Radiotherapy for Severe COVID-19 Pneumonia a Therapeutic Alternative?

Safini,

Amaoui,

Oqbani

et al. 2024

Cureus

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Low-dose radiotherapy (LD-RT) has historically been used to treat severe bacterial and viral pneumonia due to its immunomodulatory properties. However, this technique has been delayed since the advent of antibiotics and the carcinogenic risk associated with radiation therapy. Currently, it represents an alternative therapeutic in the SARS-CoV-2 pandemic which leads sometimes to fatal pneumonia, especially given the limited availability of effective treatments for severe forms of pneumonia. Numerous in vitro and in vivo studies have demonstrated the anti-inflammatory effect of LD-RT and have reported clinical and biological improvement in patients with severe pneumonia. In this literature review, we report the data and results of various published clinical trials.

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Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study

Cited by 2 publications

References 43 publications

Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study

Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study

Is Low-Dose Lung Radiotherapy for Severe COVID-19 Pneumonia a Therapeutic Alternative?

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