Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)

Inoue, Sho; Sakamoto, Yasunari; Sekino, Yusuke; Nonaka, Takashi; Iida, Hiroshi; Endo, Hideki; Koide, Takao; Nakajima, Atsushi; Maeda, Shin; Nakajima, Akira; Gotoh, Eiji; Inamori, Masahiko

doi:10.5152/tjg.2014.4768

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Further studies will be warranted to determine whether the early phase of gastric emptying such as AUC 5 value was associated with pancreatic enzyme abnormalities in FD patients. In addition, previous studies have reported that solid test meals [43] and liquid meals [44][45][46] were used for assessment of the early phase of gastric emptying. In the future, we have to compare the early phase of gastric emptying evaluated by solid test meals with liquid test meals.…”

Section: Discussionmentioning

confidence: 99%

Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities

et al. 2018

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Background/Aims: The aims of the study are to clarify the pathophysiological differences among early chronic pancreatitis (ECP), functional dyspepsia with pancreatic (FD-P) enzyme abnormalities and FD patients and to determine whether camostat mesilate, pancrelipase, and rabeprazole triple therapy improve FD symptoms in the ECP patients and FD-P patients in cross-over way. Methods: We enrolled 84 consecutive patients presenting with typical symptoms of FD patients (n = 42), ECP patients (n = 15), and FD-P patients (n = 27). Gastric emptying was assessed by the ¹³C-acetate breath test. ECP was diagnosed based on the criteria recommended by the Japan Pancreatic Association. Results: The proportions of female in ECP patients and FD-P were significantly higher compared to that in FD patients. The early phase of gastric emptying in ECP and FD-P patients was significantly disturbed compared to that in FD patients. The primary outcome of this study is that 4 weeks of camostat mesilate, pancrelipase, and rabeprazole triple therapy significantly ameliorated epigastric pain in ECP patients compared to acotiamide and rabeprazole combination therapy. Conclusion: Although there were no significant differences in pathophysiology between ECP patients and FD-P patients, triple therapy can significantly ameliorate epigastric pain in ECP patients. Further studies will be needed to clarify why triple therapy can improve epigastric pain in ECP patients.

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Section: Discussionmentioning

confidence: 99%

Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities

et al. 2018

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Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment

Jabri

Wannes

Hajji

et al. 2017

Biomedicine & Pharmacotherapy

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Overweight/bowel dysmotility crosslinking and analogous laxative actions of two edible wild fruits in obese/constipated rats

Wahabi,

Rtibi,

Brinsi

et al. 2024

Neurogastroenterology Motil

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BackgroundThe prompt development of obesity/constipation is the most serious problem for both children and adults. Limited studies suggested an association between them but lacked preclinical studies. This study allows to evaluate their crosslink and to compare the aqueous extracts laxative actions of two edible wild fruits of Arbutus unedo (AUAE) and Crataegus monogyna (CMAE) in constipated high‐fat diet (HFD) rats.MethodsWistar rats were divided into experimental groups for 13 weeks: standard (SD) and HFD groups. SD‐rats were randomly redivided into 2 groups: SD and SD + Loperamide (LOP, 3 mg/kg, b.w.). HFD‐rats were randomly reseparated into HFD‐group, (HFD + LOP)‐group, [HFD + Yohimbine (YOH, 2 mg/kg, b.w.)]‐group, [HFD+ LOP]‐groups+ various doses of AUAE or CMAE (75, 150, and 300 mg/kg, b.w.). Diversified indicators were investigated to achieve the expected objectives, including; fecal parameters, gastrointestinal transit (GIT), gastric emptying (GE), oxidative stress‐(OxS), blood biochemical analysis, and accompanied small/large bowel histological modification.Key ResultsThe liquid chromatography‐electrospray ionization‐tandem mass spectrometry (LC–ESI–MS) analysis of AUAE and CMAE allowed the identification of 11 and 6 phenolic compounds, respectively. In HFD‐rats, the subsequent dysregulation of GI motility was markedly aggravated. More importantly, with the same way (CMAE and AUAE)‐treated groups showed alleviated outcomes for the following: most stool parameters, GIT, and GE were remarkably recovered; a similar recovery pattern was observed in the histopathological structure, OxS, and blood biochemical indicators.Conclusions & InferencesOur results experimentally confirmed the crosslink between overweight and constipation and both fruits have potential as functional foods to reduce metabolic risk of the obesity associated with bowel dysmotility.

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Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)

Cited by 3 publications

References 28 publications

Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities

Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities

Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment

Overweight/bowel dysmotility crosslinking and analogous laxative actions of two edible wild fruits in obese/constipated rats

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