1993
DOI: 10.1002/roi.2970010405
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Low dose‐rate irradiation of human glioma cells and thermoradiosensitization by mild hyperthermia

Abstract: SUMMARY Human brain tumors are clinically very resistant to radiation therapy. Recent clinical trials of combined simultaneous brachytherapy and mild hyperthermia have shown great promise. In this study two relatively radioresistant human glioma cell lines have been irradiated in plateau growth phase under low dose-rate (LDR) conditions (< 1 cGy/min) with and without concurrent mild (3941°C) hyperthermia. The large degree of LDR sparing observed a t 0.88 cGy/min (LDR,) was almost completely inhibited by concur… Show more

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Cited by 10 publications
(3 citation statements)
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“…Several research studies using rodent cell lines have demonstrated the radiation sensitization in LDRI over several low dose-rate ranges from in vitro data (Ben-Hur et al 1874, Harisiadis et al 1978, Gerner et al 1983, Ling and Robinson 1988, Armour et al 1991, Spiro et al 1991, Wang et al 1992, Heller and Raaphorst 1993. Ben-Hur et al (1874) treated Chinese hamster V-79 cells and reported TER values of 1.3, 1.5 and 1.9 at 39, 40 and 41°C with an LDRI of 198cGy/h respectively.…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…Several research studies using rodent cell lines have demonstrated the radiation sensitization in LDRI over several low dose-rate ranges from in vitro data (Ben-Hur et al 1874, Harisiadis et al 1978, Gerner et al 1983, Ling and Robinson 1988, Armour et al 1991, Spiro et al 1991, Wang et al 1992, Heller and Raaphorst 1993. Ben-Hur et al (1874) treated Chinese hamster V-79 cells and reported TER values of 1.3, 1.5 and 1.9 at 39, 40 and 41°C with an LDRI of 198cGy/h respectively.…”
Section: Discussionmentioning
confidence: 95%
“…These findings strongly support the clinical usefulness of LDRI combined with mild hyperthermia. Ling and Robinson (1988) pointed out that the different radiosensitization rate due to mild hyperthermia between HDRI and LDRI was due to the reduction of the dose-rate effect. Traditionally, a dose-rate effect has been considered to occur as a result of three factors, namely sub-lethal damage repair, cell proliferation and cell cycle redistribution (Hall 1994).…”
Section: Discussionmentioning
confidence: 98%
“…This could be especially effective when combined with LDR or PDR where extensive SLDR occurs, which could be inhibited by LDMH. Several studies have shown that indeed the concomitant application of mild hyperthermia and LDR and PDR irradiation was effective in thermoradiosensitization for both treatments 8,9,17,60,68 . The phenomenon of cells being radiosensitized and at the same time being thermotolerant to heat-induced cell killing was also observed 69 .…”
Section: Thermotolerancementioning
confidence: 99%