Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines

Mancini, Francesca; Milardi, Domenico; Carfagna, P; Grande, Giuseppe; Miranda, Vincenzo; De, Cicco Nardone Alessandra; Ricciardi, Domenico; Pontecorvi, Alfredo; Marana, Riccardo; De, Cicco Nardone Fiorenzo

doi:10.1530/endoabs.56.gp128

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight of the remaining 36 studies were excluded, 10 11 12 13 14 15 16 17 leaving 17 publications related to GUNA products, 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 eight to LABO'LIFE products, 35 36 37 38 39 40 41 42 two to Boiron products 43 44 and one to a product manufactured by Laboratorios Medicor 45 as the principal basis for this scoping review.…”

Section: Resultsmentioning

confidence: 99%

The Clinical and Biological Effects of Homeopathically Prepared Signaling Molecules: A Scoping Review

Manchanda¹,

Gupta²,

Gupta³

et al. 2021

Homeopathy

View full text Add to dashboard Cite

Background Signaling molecules such as cytokines and interleukins are key mediators for the immune response in responding to internal or external stimuli. Homeopathically prepared signaling molecules have been used therapeutically for about five decades. However, these types of products are not available in many countries and their usage by homoeopaths is also infrequent. The aim of this scoping review is to map the available pre-clinical and clinical data related to the therapeutic use of homeopathically prepared signaling molecules. Methods We conducted a scoping review of clinical and pre-clinical studies of therapeutically used signaling molecules that have been prepared in accordance with an officially recognized homeopathic pharmacopoeia. Articles in peer-reviewed journals reporting original clinical or pre-clinical research of homeopathically prepared signaling molecules such as interleukins, cytokines, antibodies, growth factors, neuropeptides and hormones, were eligible. Non-English language papers were excluded, unless we were able to obtain an English translation. An appraisal of eligible studies took place by rating the direction of the outcomes on a five-point scale. The quality of the papers was not systematically assessed. Results Twenty-eight eligible papers, reporting findings for four different manufacturers' products, were identified and reviewed. Seventeen papers reported pre-clinical studies, and 11 reported clinical studies (six experimental, five observational). A wide range of signaling molecules, as well as normal T-cell expressed specific nucleic acids, were used. A majority of the products (21 of 28) contained two or more signaling molecules. The most common clinical indications were psoriasis, vitiligo, rheumatoid arthritis, respiratory allergies, polycystic ovary syndrome, and herpes. The direction of the outcomes was positive in 26 papers and unclear in two papers. Conclusion This scoping review found that there is a body of evidence on the use of homeopathically prepared signaling molecules. From a homeopathy perspective, these substances appear to have therapeutic potential. Further steps to explore this potential are warranted.

show abstract