Low‐dose thiazide diuretics in children with idiopathic renal hypercalciuria

Choi, Ji Na; Lee, Jae Seung; Smıth, Lee

doi:10.1111/j.1651-2227.2011.02191.x

Cited by 19 publications

(9 citation statements)

References 17 publications

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“…In our study, although we did not use placebo drug, most patients that were treated with cystone reported passage of stone and the size of stones decreased in ultrasound that was consistent with the results of the previous studies. Some previous studies have shown that hydrochlorothiazide is a treatment for some type of hypercalciuria that helps prevention and treatment of urinary stones, which is not consistent with the findings of the present study (16,19). Yosefi et al conducted a study on the effects of hydrochlorothiazide on prevention of recurrent urinary tract infections in children with idiopathic hypercalciuria.…”

Section: Discussioncontrasting

confidence: 95%

Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

et al. 2019

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Introduction: Urinary stones are one of the most common and painful diseases of humans after urinary tract infections and prostate diseases. Objectives: The aim of this study was comparing the efficacy and complications of combined cystone and hydrochlorothiazide with cystone monotherapy in the treatment of upper urinary stones. Patients and Methods: In this randomized clinical trial 80 patients older than 15 years old with renal and ureteral stones less than 10 mm after taking informed consent form were allocated randomly in one of two groups. Patients with azotemia, hydronephrosis, bothersome pain and pregnant women were excluded. In the first group, combinations of cystone and hydrochlorothiazide tablets (every 12 hours, two 100 mg cystone and 25 mg hydrochlorothiazide) were prescribed. In the second group, cystone were prescribed as the first group. One month later, patients were followed by kidney, ureter, and bladder x-ray (KUB) and ultrasonography and the success of treatment was determined by changing the size of stones and report of stone passage by the patients. All data were collected and analyzed by SPSS software version 23 and statistical tests. Results: The mean age of the patients in combined and single groups were 48.02±13.72 and 44.15 ± 14.86(P = 0.24) years respectively. The mean size of stone after treatment in two groups was 1.72±0.98 and 1.85±0.78 mm respectively (P=0.53). Regarding efficacy of combined and single group, more than 90% of the patients reported stones passage after the intervention (P=0.06). There were no significant differences in mean blood urea (P=0.38) and serum creatinine (P=0.53) after treatment in two groups. Conclusion: The results of this study showed that combination of cystone and hydrochlorothiazide do not increase the efficacy of cystone in treatment and passage of urinary stones, although in both groups stone passage significantly increased.

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Section: Discussioncontrasting

confidence: 95%

Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

et al. 2019

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“…This hypothesis is supported by the observation that 24-hour urine volume increased on subsequent urine analyses. An alternative explanation is that assessing urine chemistries identifies specific metabolic abnormalities that could be treated with targeted therapy, such as lemonade or citrate for patients with hypocitraturia 21 and thiazides for patients with hypercalciuria 22–26 However, in successful clinical trials of adult participants, only 22% treated with citrate and 47% of those treated with thiazides met pre-specified cut points for hypocitraturia and hypercalciuria, respectively. 23 Our study highlights the need for well-designed randomized trials to test the efficacy of targeted PPT on stone recurrence among children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Kidney Stone Recurrence among Children and Adolescents

et al. 2017

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Purpose Kidney stone disease has become increasingly common during childhood and adolescence; however, the rate of symptomatic kidney stone recurrence for pediatric patients is uncertain. Materials and Methods We performed a retrospective cohort study of patients aged 3–18 years without anatomic abnormalities or genetic causes of nephrolithiasis who presented with a first symptomatic kidney stone between 2008 and 2014. We determined recurrence rates of symptomatic nephrolithiasis, defined as a new kidney stone on ultrasound and/or CT associated with pain and/or vomiting. We also estimated associations between completing 24-hour urine analyses and symptomatic kidney stone recurrence using Kaplan-Meier curves and multivariable Cox regression models. Results Among 285 children with a median age at nephrolithiasis diagnosis of 14.8 years (IQR 11.3–16.6) who were followed for 492 person-years, 68 patients (24%) developed 86 symptomatic recurrent stones over the follow-up period. The probability of symptomatic stone recurrence was 50% three years after the index kidney stone. The median time to stone recurrence was 3 and 5 years to the first and second stone recurrence, respectively. Adjusting for confounders, including adherence to follow-up, completing a 24-hour urine analysis after a kidney stone episode was associated with a 60% decreased risk of recurrence (hazard ratio 0.40; 95% CI, 0.18–0.91). Conclusions The risk of kidney stone recurrence is high during childhood, with approximately 50% presenting with a symptomatic recurrence within three years of the first stone. The role and utility of analyzing 24-hour urine chemistries in decreasing kidney stone recurrence should be explored in future prospective studies.

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“…In addition, given the effect of thiazide diuretics in enhancing calcium reabsorption, these diuretics are used frequently in the setting of inherited forms of hypercalciuria in children (99). Rigorous studies investigating the effectiveness of thiazide diuretics alone or in combination in the pediatric cardiac population do not exist, yet anecdotal experience indicates efficacy in the acute setting.…”

Section: Thiazide Diureticsmentioning

confidence: 98%

Pediatric Cardiac Intensive Care Society 2014 Consensus Statement

McCammond

Axelrod

Bailly

et al. 2016

Pediatric Critical Care Medicine

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Fluid management is challenging in critically ill pediatric cardiac patients. A myriad of causes may be contributory, including intrinsic myocardial dysfunction with its associated neuroendocrine response, renal dysfunction with oliguria, and systemic inflammation with resulting endothelial dysfunction. The development of fluid overload has been associated with adverse outcomes, including acute kidney injury, prolonged mechanical ventilation, increased vasoactive support, prolonged hospital length of stay, and mortality. An in-depth understanding of the many factors that influence volume status is necessary to guide optimal management.

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Low‐dose thiazide diuretics in children with idiopathic renal hypercalciuria

Abstract: Our results suggest that low dose (0.5 mg/kg/day) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children.

Cited by 19 publications

References 17 publications

Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

Kidney Stone Recurrence among Children and Adolescents

Pediatric Cardiac Intensive Care Society 2014 Consensus Statement

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