“…Some previous reports have dealt with this issue presenting in part contradictory data and emphasizing the role of using standardized examination protocols (11)(12)(13). Moreover, the calculation kinetic models (compartmental vs. deconvolution) for perfusion quantification differ, and their strengths and limitations have been already reported (14,15). These models quantify perfusion parameters and allow pixel-by-pixel calculation of a range of physiological parameters (blood flow [BF], blood volume [BV], mean transit time [MTT], time to peak, and k-trans or flow extraction product, defined as the sum of flow within the microvasculature and capillary permeability) and depiction as parametric maps.…”