Low dose X –ray effects on catalase activity in animal tissue

Focea, R; Nădejde, Claudia; Creangă, Dorina; Luchian, Tudor

doi:10.1088/1742-6596/398/1/012032

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…However, increasing the irradiation dose to 15 Gy was shown to decrease its concentration significantly after exposure [42], which could be attributed to the injuries on the hydrogen bonds of its active site. The resulting balance of the two concurrent processes determines the cell's ability to decompose the hydrogen peroxide and restore or deteriorate the radiation-induced damage [41]. In this study, the exposure to 6 Gy resulted also in a significant increase of the catalase after 1 day of exposure to radiation, but it decreased by the 14 th day, which can be explained by the start of radiation-induced damage to the enzyme itself.…”

Section: Effect Of Gamma Radiationmentioning

confidence: 50%

“…This can explain its high activity demonstrated in the livers of irradiated rats compared to controls after whole body exposure to 2 and 4 Gy of gamma radiation [36] and after exposure to 10 Gy [40]. This idea was supported by the direct increase in its biosynthesis 2 h after the exposure of excised chick tissues to 0.5 and 2 Gy [41]. However, increasing the irradiation dose to 15 Gy was shown to decrease its concentration significantly after exposure [42], which could be attributed to the injuries on the hydrogen bonds of its active site.…”

Section: Effect Of Gamma Radiationmentioning

confidence: 93%

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Radio-mitigation effect of poly-MVA after exposure to an acute dose of gamma radiation

El-Marakby

Selim

Desouky

et al. 2016

Journal of Taibah University for Science

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Adult male rats were exposed to a 6 Gy single dose from a Cs-137 source. The radio-mitigation effect of poly-MVA was evaluated by daily administration of 2 ml/kg of body weight immediately after irradiation for two weeks. The morphological changes in the red blood cells were studied. The osmotic fragility and rheological properties of blood, the alteration in the contents of antioxidant enzymes (glutathione, catalase and superoxide dismutase) and lipid peroxidation in hepatic cells were determined. The results showed that exposure to radiation resulted in significant changes in cellular antioxidant enzymes (GSH, catalase and SOD) and a decrease in the blood Bingham viscosity, yield stress and aggregation index. Furthermore, it induced a slight increase in the average osmotic fragility of red blood cells accompanied by a decrease in osmotic dispersion, as well as a modification of red blood cell morphology. It also caused a significant increase (75%) in the lipid peroxidation 1 day after exposure to radiation, which persisted until the 14 th day recorded after irradiation. Oral administration of poly-MVA after irradiation reduced the radiation-induced damage, as seen in the non-significant change in lipid peroxidation compared to the control. It also resulted in improvement in the observed parameters.

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Section: Effect Of Gamma Radiationmentioning

confidence: 50%

Section: Effect Of Gamma Radiationmentioning

confidence: 93%

Radio-mitigation effect of poly-MVA after exposure to an acute dose of gamma radiation

El-Marakby

Selim

Desouky

et al. 2016

Journal of Taibah University for Science

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“…Superoxide dismutase catalyses the dismutation of O 2·− to H 2 O 2 and catalase converts two molecules of the hydrogen peroxide to molecular oxygen and two molecules of water (Edem et al., ). This increased catalase activity might be due to increased H 2 O 2 production in X‐ray‐exposed animals (Focea et al., ) when compared to the control animals. Significant reduction in GPx, catalase, SOD activities and significant improvement in GSH levels was observed upon A. vera extract administration (Rajasekaran et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…X‐ray exposure dose was standardised at the Department of Radiodiagnosis and Imaging at PGIMER, Chandigarh (data not shown). Considering the pilot studies carried out in our laboratory and reports available from literature (Focea et al., ; Haines et al, ), the mice were exposed to cumulative dose of X‐ray radiation (0.258 Gray) twice a day, for 4 days in a week. For this, mice were kept in a well‐ventilated perspex box and were exposed to X‐ray radiation.…”

Section: Methodsmentioning

confidence: 99%

Protective role ofAloe veraagainst X-ray induced testicular dysfunction

et al. 2016

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The present investigation was carried out to evaluate the possible radioprotective potential of an Aloe vera extract against whole-body X-ray irradiation-induced testicular alterations in mice. Male balb/c mice were divided into four groups: control, A. vera, X-ray and A. vera pre-treated + X-ray irradiated. Histopathological examination revealed significant structural alterations in testes after X-ray exposure, which was also associated with the presence of apoptotic cells as assessed by TUNEL assay. X-ray irradiation resulted in elevation in the levels of reactive oxygen species, lipid peroxidation, a reduction in glutathione concentration and enhanced activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase and glutathione-S-transferase. Sperm count/motility and testosterone levels were significantly decreased in the irradiated group. Irradiated animals pre-treated with A. vera extract revealed an improvement in antioxidant status, inhibition of lipid peroxides, apoptotic cell formation and enhanced testicular parameters when compared to the X-ray-exposed group. These findings suggest that A. vera extract could ameliorate X-ray-induced damage due to its free radical scavenging properties and its potential to boost cellular antioxidant defence machinery.

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“…Such exposure to radioactive agents has been shown to produce various pathological changes in living systems like lipid peroxidation (LPO) (Yagi, 1988) and damaging of cellular macromolecules. Further, studies had shown that fathers exposed to radiation are more likely to have infants who contract leukemia especially if such exposure is closer to conception or includes two or more x-rays of the lower gastrointestinal tract or lower abdomen (Focea et al, 2012). The risk of radiation is greater to unborn babies, so in pregnant patients, the benefits of x-ray should be balanced with the potential hazards, to the unborn foetus (Focea et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Radiation protection and anti-oxidative effects of garlic, onion and ginger extracts, x-ray exposed albino rats as model for biochemical studies

Nwachukwu¹,

Asagba²,

Nwose³

et al. 2014

Afr. J. Biochem. Res.

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The present study investigates and examines the comparative effects of plant extracts such as, garlic, ginger and onion on some organs (liver, kidney and heart) of x-ray exposed rats, using and assaying some biochemical enzymes. Twenty (20) albino rats with an average weight of (155.00 ± 2.01 g), divided into five groups were used for the study. The rats with exception of the control were exposed to x-ray with ionizing radiation at a dose of 525 kv/s. The results indicate some toxicity conferred on the rats were reversed when fed with diet containing garlic, ginger and onion, as evidently shown in some of the biochemical parameters examined that includes: body weight gain, plasma and femur alanine aminotransferase (ALP) activity; enzymatic changes in super oxide dismutase (SOD), catalase (CAT) level in the liver, kidney and heart. Feeding with ginger, garlic and onions extracts failed to restore the x-ray induced inhibition of aldenylate oxidase (AO) and sulphite oxidase (SO) activities in the liver and heart. Data of the study indicates that garlic and onions had more beneficial effects on radiation induced toxicity in rats, as increased body weight gain (P<0.05) of rats caused by radiation which was reduced by feeding with garlic and onion by-65.11 and-30.02%, respectively as against radiation exposed rats fed ginger (-3.17%) compared to rats treated with only x-ray. Together, the results obtained from this study suggest that garlic, ginger and onion may have significant anti-radiation properties, bearing the reversal and restoration observed after radiation exposure on some of the investigated biochemical parameters. Such properties properly harnessed will be helpful in combating cellular oxidative stress.

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Low dose X –ray effects on catalase activity in animal tissue

Cited by 11 publications

References 12 publications

Radio-mitigation effect of poly-MVA after exposure to an acute dose of gamma radiation

Radio-mitigation effect of poly-MVA after exposure to an acute dose of gamma radiation

Protective role ofAloe veraagainst X-ray induced testicular dysfunction

Radiation protection and anti-oxidative effects of garlic, onion and ginger extracts, x-ray exposed albino rats as model for biochemical studies

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